A potential new approach for preserving historical artifacts through gamma irradiation and green antimicrobials: Microbiological and theoretical screening

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dc.contributor.authorErgun, Ece
dc.contributor.authorHalkman, Hilal B. D.
dc.contributor.authorKasimfirtina, Eren
dc.contributor.authorKantoglu, Omer
dc.contributor.authorErgun, Umit
dc.contributor.authorOrhan, Ersin
dc.date.accessioned2025-10-11T20:48:27Z
dc.date.available2025-10-11T20:48:27Z
dc.date.issued2026
dc.departmentDüzce Üniversitesien_US
dc.description.abstractThis study presents a novel combined treatment process for the decontamination of historical textiles, using gamma irradiation with green antimicrobial agents. Microbiological studies and theoretical approaches were utilized to investigate the effect of treatment processes individually and in combination on isolates from the textile museum. The mean D-10 values and the required doses for complete inactivation were found to be 1.19 and 7.60 kGy for bacteria cocktail and 1.47 and 6.32 kGy for mold cocktail, respectively. The antimicrobial activities of two Schiff bases and their reduced derivatives were tested against gamma-resistant microorganisms by measuring the diameter of the inhibition zones. It was found that reduced derivatives exhibited higher antibacterial activity. All compounds were screened through an in-silico study to evaluate the physicochemical properties, drug-likeness, and toxicity profile. Molecular docking studies were performed to investigate the binding affinity of the title compounds against E. coli DNA gyrase B and topoisomerase IV. From the perspectives of both in vitro studies and computational analysis, L4 exhibited the highest biological activity. This finding revealed that the reduction of the imine bond and molecular flexibility have a significant influence on binding to the active site of the biomolecule. Finally, the combined treatment utilizing L4 with gamma irradiation demonstrated a synergistic effect, leading to a 2.6-fold reduction compared to the control, whereas the individual treatments of L4 and gamma irradiation exhibited approximately a 1-fold reduction. This synergistic effect presents an innovative approach to the historical artifact preservation, providing a more efficient and potentially safer decontamination strategy.en_US
dc.description.sponsorshipInternational Atomic Energy Agency (IAEA) through the project on Development and Implementa-tion of Cultural Heritage Preservation Using Ionizing Radiation Technology [F22082-CRP-26647]en_US
dc.description.sponsorshipTurkish Energy, Nuclear, and Mineral Research Agency (TENMAK) through Provision of Measurement, Analysis, Testing, Irradiationen_US
dc.description.sponsorshipCalibration Services and Development of Measurement Capabilities [A4.H1.F24]en_US
dc.description.sponsorshipThis study has been supported by the International Atomic Energy Agency (IAEA) through the project on Development and Implementa-tion of Cultural Heritage Preservation Using Ionizing Radiation Technology (F22082-CRP-26647) and the Turkish Energy, Nuclear, and Mineral Research Agency (TENMAK) through Provision of Measurement, Analysis, Testing, Irradiation, and Calibration Services and Development of Measurement Capabilities (A4.H1.F24) .en_US
dc.identifier.doi10.1016/j.radphyschem.2025.113247
dc.identifier.issn0969-806X
dc.identifier.issn1879-0895
dc.identifier.scopus2-s2.0-105013488237en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1016/j.radphyschem.2025.113247
dc.identifier.urihttps://hdl.handle.net/20.500.12684/21934
dc.identifier.volume239en_US
dc.identifier.wosWOS:001567709300001en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherPergamon-Elsevier Science Ltden_US
dc.relation.ispartofRadiation Physicsand Chemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmzKA_WOS_20250911
dc.subjectIonizing radiationen_US
dc.subjectCultural heritageen_US
dc.subjectAntimicrobial agentsen_US
dc.subjectCombined treatmenten_US
dc.subjectDensity functional theoryen_US
dc.subjectMolecular dockingen_US
dc.titleA potential new approach for preserving historical artifacts through gamma irradiation and green antimicrobials: Microbiological and theoretical screeningen_US
dc.typeArticleen_US

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