Synthesis of Persea americana extract based hybrid nanoflowers as a new strategy to enhance hyaluronidase and gelatinase inhibitory activity and the evaluation of their toxicity potential

Basit Öğe Kaydı
dc.authoridAnlaş, Ceren/0000-0002-7997-016X
dc.authoridÇalışkan, Ufuk Koca/0000-0002-5216-7588
dc.authoridÖZDEMİR, NALAN/0000-0002-8930-5198
dc.authorwosidAnlaş, Ceren/D-4097-2019
dc.authorwosidÇalışkan, Ufuk Koca/HIU-0019-2022
dc.authorwosidÖZDEMİR, NALAN/AAL-7083-2021
dc.contributor.authorBor, Emrah
dc.contributor.authorÇalışkan, Ufuk Koca
dc.contributor.authorAnlaş, Ceren
dc.contributor.authorDurbilmez, Goksen Dilsat
dc.contributor.authorBakirel, Tülay
dc.contributor.authorÖzdemir, Nalan
dc.date.accessioned2023-07-26T11:51:24Z
dc.date.available2023-07-26T11:51:24Z
dc.date.issued2022
dc.departmentDÜ, Eczacılık Fakültesi, Temel Eczacılık Bilimleri Bölümüen_US
dc.description.abstractThis study aimed to evaluate the hyaluronidase and gelatinase inhibitory activities and toxicity potentials of Persea americana Mill. extract and its synthesized hybrid nanoflowers. In the first part of the study, characterization of the nanoflower structures was carried out and then, enzyme inhibitory activities of the methanol extract and hybrid nanoflowers were investigated. It was determined that the enzyme inhibitory activity of both nanoflowers was higher than the methanol extract. Zinc nanoflower was more effective in hyaluronidase enzyme inhibition, while copper nanoflower showed higher inhibitory activity on gelatinase enzyme. In the second part of the study, toxicological profiles of these compounds were investigated. Toxicological evaluations demonstrated that zinc nanoflower may be a safer therapeutic alternative than the copper nanoflower, especially at high concentrations. All these data appear to contribute to the development of effective new generation preparations including nanoflowers for skin problems using Persea americana leaves extract and its nanostructures.en_US
dc.description.sponsorshipGazi University Scientific Research Projects Unit [02/2018-12]en_US
dc.description.sponsorshipAuthors would like to thank Gazi University Scientific Research Projects Unit for their support for funding this project (02/2018-12).en_US
dc.identifier.doi10.1080/24701556.2022.2072342
dc.identifier.issn2470-1556
dc.identifier.issn2470-1564
dc.identifier.scopus2-s2.0-85132605197en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.urihttps://doi.org/10.1080/24701556.2022.2072342
dc.identifier.urihttps://hdl.handle.net/20.500.12684/12555
dc.identifier.wosWOS:000791905100001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorÇalışkan, Ufuk Koca
dc.language.isoenen_US
dc.publisherTaylor & Francis Incen_US
dc.relation.ispartofInorganic and Nano-Metal Chemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmz$2023V1Guncelleme$en_US
dc.subjectPersea Americana; Nanoflowers; In Vitro Enzyme Inhibition; Skin Disorders; Toxicityen_US
dc.subjectIn-Vitro Evaluation; Oxide Nanoparticles; Green Synthesis; Silver Nanoparticles; Cancer-Cells; Comet Assay; Dna-Damage; Zinc-Oxide; Antioxidant; Amoxicillinen_US
dc.titleSynthesis of Persea americana extract based hybrid nanoflowers as a new strategy to enhance hyaluronidase and gelatinase inhibitory activity and the evaluation of their toxicity potentialen_US
dc.typeArticleen_US

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim Yok
İsim:
12555.pdf
Boyut:
2.64 MB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam Metin / Full Text
İndir

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu