Numerical analysis of a poroelastic cartilage model: Investigating the influence of changing material properties in osteoarthritis

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dc.authoriduzuner, sabri/0000-0002-9099-1324en_US
dc.authorscopusid57209810982en_US
dc.authorwosiduzuner, sabri/IVV-4834-2023en_US
dc.contributor.authorUzuner, Sabri
dc.date.accessioned2024-08-23T16:04:07Z
dc.date.available2024-08-23T16:04:07Z
dc.date.issued2024en_US
dc.departmentDüzce Üniversitesien_US
dc.description.abstractSeveral changes occur in both the cartilage's material properties and anatomical structure as osteoarthritis progresses. Unlike most numerical studies that solely consider individual changes, our study aimed to understand the impact on cartilage mechanics by considering the combined effect of material properties and cartilage thickness varied with osteoarthritis progression. In total, 3 three-dimensional finite element models, representing the intact, early, and late osteoarthritis conditions, were developed to simulate a load-bearing area in the knee. The articular cartilage was modelled as fluid-saturated linear biphasic poroelastic to incorporate solid-fluid interaction. All models underwent prolonged creep (50 N) and relaxation (0.3 mm) analyses for 600 s. In the early stage of osteoarthritis, the tibial cartilage demonstrated an overall stiffer behaviour attributed to cartilage swelling despite decreased stiffness at the material level. On the other hand, in the late stage of osteoarthritis, the decrease in cartilage thickness led to increased knee deformation. Additionally, increased permeability resulted in accelerated fluid exudation across all osteoarthritis models, and the elevation in void ratio further intensified fluid pressure within the cartilage to a higher magnitude. Furthermore, these changes collectively influenced both the magnitude and distribution of the outcomes. A holistic understanding of the material properties altered in osteoarthritis may contribute to a better understanding of the mechanical performance of cartilage during disease progression.en_US
dc.description.sponsorshipScientific and Technological Research Council of TURKEY (TUBITAK)en_US
dc.description.sponsorshipThe authors disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: Sabri UZUNER is awarded a grant by The Scientific and Technological Research Council of TURKEY (TUBITAK) to visit the University of Calgary (CANADA).en_US
dc.identifier.doi10.1177/09544089241248147
dc.identifier.issn0954-4089
dc.identifier.issn2041-3009
dc.identifier.scopus2-s2.0-85191347557en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.urihttps://doi.org/10.1177/09544089241248147
dc.identifier.urihttps://hdl.handle.net/20.500.12684/14077
dc.identifier.wosWOS:001207430500001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorUzuner, Sabrien_US
dc.language.isoenen_US
dc.publisherSage Publications Ltden_US
dc.relation.ispartofProceedings of the Institution of Mechanical Engineers Part E-Journal of Process Mechanical Engineeringen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectEarly stageen_US
dc.subjectlate stageen_US
dc.subjectosteoarthritisen_US
dc.subjectporoelasticen_US
dc.subjectfinite element methoden_US
dc.subjectJoint Contact Mechanicsen_US
dc.subjectArticular-Cartilageen_US
dc.subjectKnee Jointsen_US
dc.subjectPressureen_US
dc.subjectPermeabilityen_US
dc.subjectTransectionen_US
dc.subjectOsteotomyen_US
dc.subjectBehavioren_US
dc.subjectStressen_US
dc.subjectCreepen_US
dc.titleNumerical analysis of a poroelastic cartilage model: Investigating the influence of changing material properties in osteoarthritisen_US
dc.typeArticleen_US

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