Protective role of Proanthocyanidin in experimental ovarian torsion

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dc.contributor.authorYıldırım, Şule
dc.contributor.authorTopaloğlu, Naci
dc.contributor.authorTekin, Mustafa
dc.contributor.authorKüçük, Adem
dc.contributor.authorErdem, Havva
dc.contributor.authorErbaş, Mesut
dc.contributor.authorYıldırım, Ahmet
dc.date.accessioned2020-04-30T13:33:11Z
dc.date.available2020-04-30T13:33:11Z
dc.date.issued2015
dc.departmentDÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.description.abstractBackground: Proanthocyanidin is a potent bioactive antioxidant naturally occurring in grape seed and acts as reactive oxygen species (ROS) scavenger. The aim of this study was to investigate the effects of proanthocyanidinin in experimental ovarian torsion injury. Methods: Twenty four rats were randomly divided into three groups (n=8). Group 1: the laparotomy group, group 2: ovarian torsion group, and group 3: intervention group administered proanthocyanidinin of 50 mg/kg before bilateral ovarian ischemia and reperfusion. Histologic examination and scoring was done at the end of the experiment. Statistical analyses were performed using the SPSS v. 19. Results: Ovarian histopathologic findings of all three groups were significantly different in terms of hemorrhage (p<0.001), edema (p=0.001) and vascular dilatation (p<0.001). Pathologic changes induced by I/R were reduced in ovaries of rats administered proanthocyanidin, in particular, hemorrhage, edema and vascular dilatation. Conclusion: Proanthocyanidin, known as free radical scavenger and antioxidant, is protective against tissue damage induced by ischemia and/or ischemia/reperfusion in rat ovaries.en_US
dc.identifier.issn1016-1430
dc.identifier.scopusqualityN/Aen_US
dc.identifier.urihttps://hdl.handle.net/20.500.12684/568
dc.identifier.volume29en_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherTehran University of Medical Sciencesen_US
dc.relation.ispartofMedical Journal of the Islamic Republic of Iranen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectFertility; Ischemia Reperfusion; Ovarian torsion; Proanthocyanidininen_US
dc.titleProtective role of Proanthocyanidin in experimental ovarian torsionen_US
dc.typeArticleen_US

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