Aromatherapeutic essential oils and their pharmaceutical combinations: Tools for inhibition of quorum sensing activity and biofilm formation of human pathogens

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dc.authoridÇalışkan, Ufuk Koca/0000-0002-5216-7588
dc.authorwosidÇalışkan, Ufuk Koca/HIU-0019-2022
dc.contributor.authorÖzfenerci, Müjgan
dc.contributor.authorBali, Elif Burcu
dc.contributor.authorErdönmez, Demet
dc.contributor.authorÇalışkan, Ufuk Koca
dc.date.accessioned2023-07-26T11:54:15Z
dc.date.available2023-07-26T11:54:15Z
dc.date.issued2022
dc.departmentDÜ, Eczacılık Fakültesi, Temel Eczacılık Bilimleri Bölümüen_US
dc.description.abstractBackground and Aims: Aromatherapy, as one of the complementary therapies, uses essential oils as the main therapeutic agents to treat several diseases. In the present study, it was aimed to investigate inhibition of quorum sensing (QS) and biofilm formation of aromatherapeutic essential oils (AEOs) and their pharmaceutical combinations (PC-I and PC-II). Methods: The anti-QS potential of AEOs were determined using the biosensor strains Chromobacterium violaceum ATCC 12472 and Pseudomonas aeruginosa PA01. Anti-QS activity was detected by agar-well diffusion and violacein pigment inhibition assays. Blocking of PA01 swim and swarm motilities and biofilm formation was also performed. Results: Most of the AEOs demonstrated highly active (>95%) violacein pigment inhibition. Additionally, they inhibited swarming (40.34%-72.80%) and swimming (20.06%-50.08%) motilities of PA01. Moreover, the majority of AEOs also decreased the biofilm formation, particularly on P. aeruginosa and S. aureus. Conclusion: Consequently, aromatherapeutic formulations might be a complementary or prophylactic cure for infectious disease by their anti-OS and antibiofilm activities rather than just antimicrobial effects.en_US
dc.description.sponsorshipScientific Research Projects Unit of Gazi University, Ankara,Turkiye [02/2019-12]en_US
dc.description.sponsorshipThis study was supported by the Scientific Re-search Projects Unit of Gazi University, Ankara,Turkiye (Grant Number: 02/2019-12) .en_US
dc.identifier.doi10.26650/IstanbulJPharm.2022.998774
dc.identifier.endpage63en_US
dc.identifier.issn2587-2087
dc.identifier.issue1en_US
dc.identifier.startpage54en_US
dc.identifier.trdizinid1127016en_US
dc.identifier.urihttps://doi.org/10.26650/IstanbulJPharm.2022.998774
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/1127016
dc.identifier.urihttps://hdl.handle.net/20.500.12684/12778
dc.identifier.volume52en_US
dc.identifier.wosWOS:000793925000008en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.institutionauthorErdönmez, Demet
dc.institutionauthorÇalışkan, Ufuk Koca
dc.language.isoenen_US
dc.publisherIstanbul Univ, Fac Pharmacyen_US
dc.relation.ispartofIstanbul Journal of Pharmacyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmz$2023V1Guncelleme$en_US
dc.subjectAromatherapeutic Essential Oils; Antibiofilm; Quorum Sensing; Pseudomonas Aeruginosa Pa01; Synergistic Effecten_US
dc.subjectAnti-Biofilm; Chromobacterium-Violaceum; Pseudomonas-Aeruginosa; Antibacterial; Fluorescens; Antioxidant; Componentsen_US
dc.titleAromatherapeutic essential oils and their pharmaceutical combinations: Tools for inhibition of quorum sensing activity and biofilm formation of human pathogensen_US
dc.typeArticleen_US

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