The efficacy of flupenthixol decanoate in bipolar disorder patients who have no sufficient remission with existing treatments

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dc.contributor.authorEker, Salih Saygın
dc.contributor.authorAkkaya, Cengiz
dc.contributor.authorPirinççi, Erdal
dc.contributor.authorCangür, Şengül
dc.contributor.authorKırlı, Selçuk
dc.date.accessioned2020-04-30T23:33:36Z
dc.date.available2020-04-30T23:33:36Z
dc.date.issued2015
dc.departmentDÜ, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.descriptionWOS: 000356969000009en_US
dc.description.abstractObjective: It is aimed to evaluate the prophylactic effect of flupenthixol decanoate in remitted BD patients. Methods: Remitted patients with bipolar disorder (BD), who had at least one mood episode each year in the last five years in spite of adequate pharmacotherapy, were included. Flupenthixol decanoate 20 mg/ml was administered in every two weeks. Hamilton Depression Rating Scale (HDRS), Young Mania Rating Scale (YMRS), Bipolar Disorder Functioning Questionnaire (BDFQ), General Assessment of Functionality (GAF) and Side Effect Rating Scale (UKU) were applied. Patients were followed up for 12 months. Results: Eight patients with a mean age of 34.7 +/- 7.5 were enrolled to the study. None of the patients were under monotherapy before the study enrollment. Three (37.5%) of the three patients were dropped out. The data of remaining 5 patients' were evaluated. At the end of the study mean number of mood episodes declined to 0.2 +/- 0.4 per year indicating a statistical significance and the mean score of BDFQ declined to 119.6 +/- 2.7. Conclusions: Flupenthixol decanoate significantly improved functionality and decreased the number of mood episodes allowing an alternative treatment even in remitted BD patients.en_US
dc.identifier.doi10.5455/apd.190838en_US
dc.identifier.endpage367en_US
dc.identifier.issn1302-6631
dc.identifier.issue5en_US
dc.identifier.startpage364en_US
dc.identifier.urihttps://doi.org/10.5455/apd.190838
dc.identifier.urihttps://hdl.handle.net/20.500.12684/5006
dc.identifier.volume16en_US
dc.identifier.wosWOS:000356969000009en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherCumhuriyet Univ Tip Fak Psikiyatri Anabilim Dalien_US
dc.relation.ispartofAnadolu Psikiyatri Dergisi-Anatolian Journal Of Psychiatryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectbipolar disorderen_US
dc.subjectdepot neurolepticsen_US
dc.subjectprophylaxisen_US
dc.subjectflupenthixol decanoateen_US
dc.titleThe efficacy of flupenthixol decanoate in bipolar disorder patients who have no sufficient remission with existing treatmentsen_US
dc.typeArticleen_US

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