Histopathological Analysis of the Role of Horn on the Memory/Intelligence Processing Areas of the Brain and the Blood Brain Barrier in Female Sheep

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dc.authoridCinar Tanriverdi, Esra/0000-0001-8857-3986;
dc.contributor.authorOzturk, Cengiz
dc.contributor.authorYarar, Burhan
dc.contributor.authorKeles, Osman Nuri
dc.contributor.authorMalkoc, Ismail
dc.contributor.authorCetin, Zehra Aslihan
dc.contributor.authorTanriverdi, Esra Cinar
dc.contributor.authorAydin, Mehmet Dumlu
dc.date.accessioned2025-10-11T20:48:52Z
dc.date.available2025-10-11T20:48:52Z
dc.date.issued2024
dc.departmentDüzce Üniversitesien_US
dc.description.abstractBecause horned animals are prone to conflict, they may have a higher risk of developing a brain contusion as a result of a horn strike. Repeated brain trauma can affect the hippocampus, which is involved in memory and orientation. The aims of study thi was to histopathologically examine the blood-brain barrier (BBB) of the hippocampus in horned and hornless female sheep. 4 Skulls horned of and 6 hornless female sheep aged 16 +/- 4 months were obtained from the abattoir. Brains were carefully removed and preserved in 10 % formalin for 5 days. Sections were taken from bilateral hippocampus. Specimens were stained with hematoxylin-eosin (H&E) neland Tu methods, and the histopathologic structures of the BBB were examined by light microscopy. BBB damage scores evaluated. ltsThe wreresu analyzed by Mann-Whitney U test. The BBB damage score was found to be higher in horned female sheep. Astrocytes was more branching and BBB was more intact in hornless female sheep. This is considered that more astrocyte branches may play an importanthe role in protective mechanism. The difference in intracerebral defense mechanism against brain trauma in female sheep may serveel as fora mod investigating molecular mechanisms. The impairment of the BBB in the hippocampal region of horned female sheep may resulteir in th memory, intelligence, and navigational abilities being lower than those of hornless female sheep. This could open the horizon better f advances in human and animal brain health.en_US
dc.description.sponsorshipAtaturk University BAP unit [TSA 2023-11896]en_US
dc.description.sponsorshipThis study was supported by Ataturk University BAP unit (scientific research project unit - project number: TSA 2023-11896)en_US
dc.identifier.endpage1415en_US
dc.identifier.issn0717-9502
dc.identifier.issn0717-9367
dc.identifier.issue5en_US
dc.identifier.scopus2-s2.0-85208924126en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage1410en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12684/22146
dc.identifier.volume42en_US
dc.identifier.wosWOS:001459855900029en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherSoc Chilena Anatomiaen_US
dc.relation.ispartofInternational Journal of Morphologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmzKA_WOS_20250911
dc.subjectBlood brain barrieren_US
dc.subjectFemale sheepen_US
dc.subjectHippocampusen_US
dc.subjectHornen_US
dc.subjectTraumaen_US
dc.titleHistopathological Analysis of the Role of Horn on the Memory/Intelligence Processing Areas of the Brain and the Blood Brain Barrier in Female Sheepen_US
dc.typeArticleen_US

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