How Important Is Liver Damage During COVID-19?

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dc.contributor.authorEkın, Nazim
dc.contributor.authorKılıç, Jihat
dc.contributor.authorBacaksız, Ferhat
dc.contributor.authorEbik, Berat
dc.date.accessioned2023-04-10T20:19:39Z
dc.date.available2023-04-10T20:19:39Z
dc.date.issued2021
dc.departmentRektörlük, Rektörlüğe Bağlı Birimler, Düzce Üniversitesi Dergilerien_US
dc.description.abstractAim: The present study aimed to examine the prevalence of liver dysfunction in patients hospitalized due to coronavirus disease 2019 (COVID-19) and to investigate the role of liver dysfunction in predicting intensive care unit admission and mortality. Material and Methods: A total of 2168 patients who had no previously known chronic liver disease and were found to be COVID-19 positive on polymerase chain reaction test were divided into mild and severe COVID-19 groups. The effect of the development of liver damage on the course and prognosis of COVID-19 was investigated. Results:Elevatedliverenzymesdevelopedin26.3%(n=461)ofthepatientswithmild COVID-19 and in 45.3% (n=189) of the patients with severe COVID-19. The highest ALT and AST elevation was detected in patients using more than one drug with antibiotics (p<0.001). Severe hepatitis developed in 1.4% (n=25) of the patients with mild COVID-19 and 6.5% (n=27) of the patients with severe COVID-19 (p<0.001). There was a weak negative correlation between ALT and albumin (p=0.017, r=-0.497), while a weak positive correlation with bilirubin (p=0.024, r=0.352), a moderate positive correlation with ferritin (p=0.016, r=0.504), and a weak positive correlation with INR (p=0.022, r=0.383) were found in patients with severe COVID-19. Conclusion: The results showed that 30% of COVID-19 patients had impaired liver function of varying severity and that liver damage was more common in patients with severe COVID-19. It was also determined that liver damage occurring during COVID-19 was an indicator of intensive care requirement and the mortality risk.en_US
dc.identifier.doi10.18678/dtfd.947189
dc.identifier.endpage243en_US
dc.identifier.issn1307-671X
dc.identifier.issue3en_US
dc.identifier.startpage239en_US
dc.identifier.trdizinid495747en_US
dc.identifier.urihttp://doi.org/10.18678/dtfd.947189
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/495747
dc.identifier.urihttps://hdl.handle.net/20.500.12684/11459
dc.identifier.volume23en_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.relation.ispartofDüzce Tıp Fakültesi Dergisi
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCOVID-19en_US
dc.titleHow Important Is Liver Damage During COVID-19?en_US
dc.typeArticleen_US

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