Adolesan Çocuklarda Hepatit B Belirteçlerinin İncelenmesi-Düzce Üniversitesi Hastanesi 5 Yıllık Sonuçlar
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Tarih
2021
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info:eu-repo/semantics/openAccess
Özet
Amaç: Hepatit B virüsü (HBV), akut ve kronik karaciğer hastalığının ve bunlara bağlı morbidite ve mortalitenin başlıca nedenidir. Ülkemizde 1998 yılında Hepatit B aşısı rutin aşı takvimine alındı. Bu çalışmada, ülkemizde Hepatit B aşısı uygulanmaya başlandıktan sonra doğan çocuklardaki Hepatit B belirteçlerinin değerlendirilmesini amaçladık.Gereç ve Yöntemler: Düzce Üniversitesi Tıp Fakültesi Çocuk Polikliniklerine başvurup HBV seroloji testleri yapılan, rutin aşı takviminde aksama olmayan ve yaşları 10-19 arasında olan 310 çocuğun Hepatit B belirteçleri değerlendirildi. Çocukların tam aşılı sayılabilmeleri için 1999 ve sonrası doğumlu olanlar çalışmaya dahil edildi. Aynı hastanın farklı zamanlarda yapılan değerlendirmeleri çalışma dışı bırakıldı.Bulgular: Çalışmaya 166 (%53,5) erkek ve 144 (%46,5) kız toplam 310 çocuk alındı. Çocukların 192’sinde anti-HBs pozitif (%61,9), 118’inde (%38,1) negatif saptandı. Cinsiyetler açısından anti-HBs ve HBsAg pozitifliği karşılaştırıldığında anlamlı fark bulunmadı. Sonuç: Hepatit B aşısı sonrası bireylerin seropozitiflik durumları üzerine günümüzde fazla araştırma yapılmıyor olsa da çalışmamızda saptanan anti-HBs pozitiflik oranları; geniş bir popülasyonda yeni bir çalışma planlanarak aşılama sonrası anti-HBs düzeyinin değerlendirilmesinin tekrar gündeme gelmesini, belki de kişiden kaynaklanan sigara içme, fazla kilo problemi veya aşıların uygulanması yönünden kaynaklanan aşı transportu, saklama ve uygulama problemleri gibi sorunların ortaya çıkmasını sağlayarak, toplumda saptanan pozitif anti-HBs yüzdesinin istenilen düzeye gelmesini sağlayacaktır.
Aim: Hepatitis B virus (HBV) is the main cause of acute and chronic liver disease and associated with morbidity and mortality. Hepatitis B vaccine was included in the routine vaccination schedule in 1998 in our country, In this study, we aimed to evaluate the Hepatitis B markers in children born after hepatitis B vaccination was included in vaccination schedule in our country. Material and Methods: Hepatitis B markers of 310 children, between the ages of 10-19 who were admitted to Düzce University Medical Faculty Pediatric Outpatient Clinics, were evaluated. Children born after 1999 were included in the study, so that they can be considered fully vaccinated. Evaluations of the same patient at different times were excluded from the study. Results: A total of 310 children, 166 (53.5%) boys and 144 (46.5%) girls, were included in the study. Anti-HBs was positive in 192 (61.9%) of the children, and negative in 118 (38.1%). When anti-HBs and HBsAg positivity were compared in terms of gender, no significant difference was found. Conclusion: Although there is not much research today on the seropositivity of individuals after hepatitis B vaccine, we hope that the anti-HBs positivity rates found in our study; will lead to plan new studies in a large population about the positivity of anti-HBs detected in the society, with considering the effect of the emergence problems such as smoking, overweight problem or vaccine transport, storage and administration of vaccines on anti-HBs positivity rates, and will ensure that the percentage reaches to desired level.
Aim: Hepatitis B virus (HBV) is the main cause of acute and chronic liver disease and associated with morbidity and mortality. Hepatitis B vaccine was included in the routine vaccination schedule in 1998 in our country, In this study, we aimed to evaluate the Hepatitis B markers in children born after hepatitis B vaccination was included in vaccination schedule in our country. Material and Methods: Hepatitis B markers of 310 children, between the ages of 10-19 who were admitted to Düzce University Medical Faculty Pediatric Outpatient Clinics, were evaluated. Children born after 1999 were included in the study, so that they can be considered fully vaccinated. Evaluations of the same patient at different times were excluded from the study. Results: A total of 310 children, 166 (53.5%) boys and 144 (46.5%) girls, were included in the study. Anti-HBs was positive in 192 (61.9%) of the children, and negative in 118 (38.1%). When anti-HBs and HBsAg positivity were compared in terms of gender, no significant difference was found. Conclusion: Although there is not much research today on the seropositivity of individuals after hepatitis B vaccine, we hope that the anti-HBs positivity rates found in our study; will lead to plan new studies in a large population about the positivity of anti-HBs detected in the society, with considering the effect of the emergence problems such as smoking, overweight problem or vaccine transport, storage and administration of vaccines on anti-HBs positivity rates, and will ensure that the percentage reaches to desired level.
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Düzce Üniversitesi Sağlık Bilimleri Enstitüsü Dergisi
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Cilt
11
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2
