Effects of Laboratory Parameters on Tear Tests and Optical Coherence Tomography Findings in Pediatric Celiac Disease

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dc.contributor.authorVatansever, Mustafa
dc.contributor.authorDursun, Özer
dc.contributor.authorTezol, Özlem
dc.contributor.authorUsta, Yusuf
dc.contributor.authorDinç, Erdem
dc.contributor.authorSarı, Ayça
dc.contributor.authorVatansever, Esra Danacı
dc.date.accessioned2023-04-10T20:20:59Z
dc.date.available2023-04-10T20:20:59Z
dc.date.issued2022
dc.departmentRektörlük, Rektörlüğe Bağlı Birimler, Düzce Üniversitesi Dergilerien_US
dc.description.abstractAim: The aim of this study was to evaluate the tear parameters and optical coherence tomography (OCT) findings in children with celiac disease (CD) and to investigate the relationship between these findings and laboratory data. Material and Methods: The study included 100 eyes of 50 CD patients as well as 110 eyes of 55 healthy subjects with no ocular pathology as a control group. Best corrected visual acuity was evaluated, baseline tear volume was estimated using standard Schirmer’s test, and fluorescein tear film break-up time (TBUT) was determined for all participants. Pupillary dilation was induced and macular sections and optic disc sections were obtained with OCT. Results: The patient and control groups showed no statistically significant differences in terms of age and gender distribution (p=0.490, and p=0.930, respectively). Mean Schirmer’s test measurement was significantly lower in the CD patients compared to the control group (14.07±5.14 mm vs. 20.20±3.93 mm, p<0.001). TBUT was also shorter in the CD patients compared to the control subjects (10.86±3.51 s vs. 15.25±2.49 s, p<0.001). Mean total retinal thickness and outer retinal thickness values were significantly lower in the patient group than in the control group (p<0.001, for both parameters). In addition, the mean retinal nerve fiber layer (RNFL) thickness measurement was significantly thinner in the patient group than in the control group (p<0.001). Conclusion: In the presented study, it was observed that macular and RNFL thickness were decreased in children with CD compared to the control group, and tear tests were also impaired.en_US
dc.identifier.doi10.18678/dtfd.1082300
dc.identifier.endpage125en_US
dc.identifier.issn1307-671X
dc.identifier.issue2en_US
dc.identifier.startpage121en_US
dc.identifier.trdizinid1115665en_US
dc.identifier.urihttp://doi.org/10.18678/dtfd.1082300
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/1115665
dc.identifier.urihttps://hdl.handle.net/20.500.12684/11505
dc.identifier.volume24en_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.relation.ispartofDüzce Tıp Fakültesi Dergisi
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCeliac diseaseen_US
dc.subjectlaboratory parametersen_US
dc.subjecttear filmen_US
dc.subjectoptical coherence tomographyen_US
dc.subjectpediatric patientsen_US
dc.titleEffects of Laboratory Parameters on Tear Tests and Optical Coherence Tomography Findings in Pediatric Celiac Diseaseen_US
dc.typeArticleen_US

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