Acil Servis Kırmızı Alanda İlaç-İlaç Etkileşimleri: Retrospektif Bir Çalışma
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Tarih
2024
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Cilt Başlığı
Yayıncı
Düzce Üniversitesi
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Amaç: Bu çalışmanın amacı, acil servislere başvuran yetişkin hastalarda ilaç-ilaç etkileşimi potansiyelini değerlendirmektir.Gereç ve Yöntemler: Bu kesitsel çalışmaya, acil servisin kırmızı bölgesine kabul edilen, muayene edilen, tedavi edilen ve birden fazla ilaç alan 410 hasta dahil edilmiştir. İlaç-ilaç etkileşimi analizi LexiInteract yazılımı kullanılarak gerçekleştirilmiştir.Bulgular: Hastaların ortanca yaşı 63 (aralık, 19-96) yıl olup %55,4'ü (n=227) kadın ve %44,5’i (n=183) erkektir. Hastalar arasında toplam 1.230 ilaç tespit edilmiştir. 181 (%44,1) hastada 330 adet olası ilaç-ilaç etkileşimi tespit edilmiştir. Erkek ve kadın hastalar arasında ilaç-ilaç etkileşimi oranları bakımından anlamlı bir fark bulunmazken (p=0,658), 65 yaş ve üzeri hastalarda (p=0,048) ve çoklu ilaç kullanımı olan hastalarda (p lt;0,001) bu oran daha yüksekti. Ayrıca, serebrovasküler hastalık (p=0,038) ve travma (p=0,002) ile başvuran hastalarda da etkileşim oranları daha yüksek idi. Lexicomp© ilaç bilgi sistemine göre, olası ilaç-ilaç etkileşimleri risk kategorisi C (n=299, %72,9), risk kategorisi D (n=22, %5,4) ve risk kategorisi X (n=9, %2,2) olarak sınıflandırıldı. En sık etkileşime giren ilaç çiftleri, C kategorisinde Furosemid-Salbutamol, D kategorisinde Enoksaparin-Asetilsalisilik asit ve X kategorisinde Deksketoprofen-Asetilsalisilik asit idi.Sonuç: Acil servisin kırmızı bölgesinde tedavi edilen hastaların neredeyse yarısı ilaç etkileşimi riski altındaydı. Acil servis hasta bakımının kritik alanlarında tıbbi talimatlara başlamadan önce ilaç-ilaç etkileşimi riskinin değerlendirilmesi esastır ve potansiyel yan etkilerle ilgili olarak takip düzenlenmelidir.
Aim: This study aimed to assess the potential for drug-drug interactions in adult patients admitted to the emergency departments.Material and Methods: This cross-sectional study included 410 patients who were admitted to the red zone of the emergency departments, examined, treated, and received multiple medications. Drug-drug interaction analysis was conducted using LexiInteract software.Results: The median age of patients was 63 (range, 19-96) years, with 55.4% (n=227) being female and 44.6% (n=183) were male. A total of 1,230 medications were identified among the patients. In 181 (44.1%) patients, 330 possible drug-drug interactions were detected. While there was no significant difference in the rate of drug-drug interactions between male and female patients (p=0.658), this rate was higher in patients aged 65 years and over (p=0.048) and patients with polypharmacy (p lt;0.001). Also, the interaction rates were higher in patients admitted with cerebrovascular disease (p=0.038) and trauma (p=0.002). According to the Lexicomp© drug information system, potential drug-drug interactions were classified into risk category C (n=299, 72.9%), risk category D (n=22, 5.4%), and risk category X (n=9, 2.2%). The most frequently interacting drug pairs were Furosemide-Salbutamol in category C, Enoxaparin-Acetylsalicylic acid in category D, and Dexketoprofen-Acetylsalicylic acid in category X.Conclusion: Nearly half of the patients treated in the red zone of the emergency department were at risk of drug interactions. Assessing the risk of drug-drug interactions is essential before initiating medical instructions in critical areas of emergency department patient care, and follow-up should be organized about potential adverse effects.
Aim: This study aimed to assess the potential for drug-drug interactions in adult patients admitted to the emergency departments.Material and Methods: This cross-sectional study included 410 patients who were admitted to the red zone of the emergency departments, examined, treated, and received multiple medications. Drug-drug interaction analysis was conducted using LexiInteract software.Results: The median age of patients was 63 (range, 19-96) years, with 55.4% (n=227) being female and 44.6% (n=183) were male. A total of 1,230 medications were identified among the patients. In 181 (44.1%) patients, 330 possible drug-drug interactions were detected. While there was no significant difference in the rate of drug-drug interactions between male and female patients (p=0.658), this rate was higher in patients aged 65 years and over (p=0.048) and patients with polypharmacy (p lt;0.001). Also, the interaction rates were higher in patients admitted with cerebrovascular disease (p=0.038) and trauma (p=0.002). According to the Lexicomp© drug information system, potential drug-drug interactions were classified into risk category C (n=299, 72.9%), risk category D (n=22, 5.4%), and risk category X (n=9, 2.2%). The most frequently interacting drug pairs were Furosemide-Salbutamol in category C, Enoxaparin-Acetylsalicylic acid in category D, and Dexketoprofen-Acetylsalicylic acid in category X.Conclusion: Nearly half of the patients treated in the red zone of the emergency department were at risk of drug interactions. Assessing the risk of drug-drug interactions is essential before initiating medical instructions in critical areas of emergency department patient care, and follow-up should be organized about potential adverse effects.
Açıklama
Anahtar Kelimeler
İlaç etkileşimi, acil servis, kırmızı bölge, klinik eczacı, Drug interaction, emergency service, red zone, clinical pharmacist
Kaynak
Düzce Tıp Fakültesi Dergisi
WoS Q Değeri
Scopus Q Değeri
Cilt
26
Sayı
3
