Some Alternative Methods to the Use of Laboratory Animals in Medical Research

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dc.authorscopusid56156721800en_US
dc.authorscopusid25229718700en_US
dc.contributor.authorKiliçcioğlu, İ.
dc.contributor.authorDülger, Görkem
dc.date.accessioned2024-08-23T16:07:30Z
dc.date.available2024-08-23T16:07:30Z
dc.date.issued2024en_US
dc.departmentDüzce Üniversitesien_US
dc.description.abstractExperimental animals have long been used for research and educational purposes. However, in recent years, ethical debates regarding the rights of animals to life have also become important. It is advocated that animal experiments can be carried out for scientific goals that can contribute to human and animal welfare in the long term and in cases where there are no alternative methods. The principles of “replacement”, “reduction”, and “refinement”, known as the 3R rule, have been updated as 4R with the addition of the “responsibility” principle. These principles provide basic guidance for the ethical use of animals in scientific experiments. Techniques that can be alternatives to animal experiments in research and biological effect studies to test synthesized drug candidate compounds and various chemicals have been developed. In vitro cell culture techniques and bioimaging methods are very important alternatives to in vivo animal experiments. The micro-dose technique is another alternative method that reveals the effects of drug candidate compounds on volunteer individuals at very low doses without using animals. Software databases and in silico computer simulations are also gaining importance in research institutions as an alternative to animal experiments. In this review, the fundamentals of animal research ethics and emerging alternatives to reduce animal use in medical experiments were discussed. © 2024, Duzce University Medical School. All rights reserved.en_US
dc.identifier.doi10.18678/dtfd.1496949
dc.identifier.endpage103en_US
dc.identifier.issn1307-671X
dc.identifier.issueS1en_US
dc.identifier.scopus2-s2.0-85197488016en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage100en_US
dc.identifier.urihttps://doi.org/10.18678/dtfd.1496949
dc.identifier.urihttps://hdl.handle.net/20.500.12684/14692
dc.identifier.volume26en_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherDuzce University Medical Schoolen_US
dc.relation.ispartofDüzce Tıp Fakültesi Dergisi
dc.relation.publicationcategoryDiğeren_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectalternative methodsen_US
dc.subjectethicsen_US
dc.subjectExperimental animalsen_US
dc.subjectanimal experimenten_US
dc.subjectanimal modelen_US
dc.subjectanimal useen_US
dc.subjectanimal welfareen_US
dc.subjectbiological activityen_US
dc.subjectcell culture techniqueen_US
dc.subjectcomputer modelen_US
dc.subjectcomputer simulationen_US
dc.subjectdrug microdoseen_US
dc.subjecthumanen_US
dc.subjectin vitro studyen_US
dc.subjectlow drug doseen_US
dc.subjectmedical researchen_US
dc.subjectmouseen_US
dc.subjectnonhumanen_US
dc.subjectraten_US
dc.subjectreviewen_US
dc.titleSome Alternative Methods to the Use of Laboratory Animals in Medical Researchen_US
dc.title.alternativeTıbbi Araştırmalarda Laboratuvar Hayvanlarının Kullanımına Alternatif Bazı Yöntemleren_US
dc.typeReviewen_US

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