Enhanced Enzyme Inhibitory Effects ofthe Nanohybrid Eggplant Extract: An Unusual Pharmaceutical Form for Medicinal Plant

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dc.authoridÖZDEMİR, NALAN/0000-0002-8930-5198en_US
dc.authoridDONMEZ, CEYLAN/0000-0002-8005-4425en_US
dc.authorid, Nuraniye/0000-0002-4674-7009en_US
dc.authorwosidÖZDEMİR, NALAN/AAL-7083-2021en_US
dc.contributor.authorDonmez, Ceylan
dc.contributor.authorKoca-Caliskan, Ufuk
dc.contributor.authorEruygur, Nuraniye
dc.contributor.authorAltinkaynak, Cevahir
dc.contributor.authorOzdemir, Nalan
dc.date.accessioned2024-08-23T16:03:38Z
dc.date.available2024-08-23T16:03:38Z
dc.date.issued2024en_US
dc.departmentDüzce Üniversitesien_US
dc.description.abstractObjective: Recently, biosynthesis/synthesis of nanoflowers has become very attractive for chemical and pharmaceutical sciences, and enhanced enzyme activities. Various plant extracts and their active compounds are effectively used as organic component for novel nanoflowers synthesis. Solanum melongena L., commonly known as eggplant in English, a vegetable and medicinal plant belongs to Solanaceae family has several advantages in materials synthesis due to cheap and obtained easily. The aim of this study is to compare the enzyme ((alpha-glucosidase (AGase), alpha-amylase (AAase), tyrosinase (Tyr), acetylcholinesterase (AChE) and butyryl cholinesterase (BChE)) inhibitory effects of the eggplant' calyx extract and its Solanum-inorganic hybrid nanoflower (Sm-ihNFs) via in vitro experimental Methods: The hybrid nanoflower was formed (NF) with organic molecules, eggplant extract (Sm), and inorganic compounds, copper to enhance the catalytic activities. The inhibition capacities of the eggplant extract, and its hybrid nanoflower were evaluated on selected enzymes (AGase, AAase, Tyr, AChE and BChE) which play significant roles physiologically by in vitro tests in this study. Results: According to inhibition percentages and IC50 values, Sm-ihNFs showed higher inhibitory activities on enzymes other than ache than the plain crude plant extract. Among all the enzymes that were studied, Sm-ihNFs demonstrated significantly higher alpha-glucosidase and alpha-amylase inhibition activities compared to acarbose. And when compared to galantamine hydrobromide Sm-ihNFs showed higher enzyme inhibition and significant IC50 value. Conclusion: It was thought that Sm-ihNFs prepared from eggplant extract may have promising potential for antidiabetic drug formulations in the future. The hybrid nanoflowers will be promising and guide for the future work in terms of pharmaceutical and cosmeceutical industry.en_US
dc.identifier.doi10.33808/clinexphealthsci.1074661
dc.identifier.endpage38en_US
dc.identifier.issn2459-1459
dc.identifier.issue1en_US
dc.identifier.startpage32en_US
dc.identifier.urihttps://doi.org/10.33808/clinexphealthsci.1074661
dc.identifier.urihttps://hdl.handle.net/20.500.12684/13838
dc.identifier.volume14en_US
dc.identifier.wosWOS:001198198400001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherMarmara Univ, Inst Health Sciencesen_US
dc.relation.ispartofClinical And Experimental Health Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectSolanum melongenaen_US
dc.subjectnanofloweren_US
dc.subjectalpha-glucosidase amylaseen_US
dc.subjecttyrosinaseen_US
dc.subjectcholinesterasesen_US
dc.subjectBioassay Guided Isolationen_US
dc.subjectSolanum-Melongenaen_US
dc.subjectAlpha-Glucosidaseen_US
dc.subjectAqueous Extracten_US
dc.subjectIn-Vitroen_US
dc.subjectAntioxidanten_US
dc.subjectPerformanceen_US
dc.subjectNanoflowersen_US
dc.subjectNanoparticlesen_US
dc.subjectBiosynthesisen_US
dc.titleEnhanced Enzyme Inhibitory Effects ofthe Nanohybrid Eggplant Extract: An Unusual Pharmaceutical Form for Medicinal Planten_US
dc.typeArticleen_US

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