Enhanced Enzyme Inhibitory Effects ofthe Nanohybrid Eggplant Extract: An Unusual Pharmaceutical Form for Medicinal Plant
Küçük Resim Yok
Tarih
2024
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Marmara Univ, Inst Health Sciences
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Objective: Recently, biosynthesis/synthesis of nanoflowers has become very attractive for chemical and pharmaceutical sciences, and enhanced enzyme activities. Various plant extracts and their active compounds are effectively used as organic component for novel nanoflowers synthesis. Solanum melongena L., commonly known as eggplant in English, a vegetable and medicinal plant belongs to Solanaceae family has several advantages in materials synthesis due to cheap and obtained easily. The aim of this study is to compare the enzyme ((alpha-glucosidase (AGase), alpha-amylase (AAase), tyrosinase (Tyr), acetylcholinesterase (AChE) and butyryl cholinesterase (BChE)) inhibitory effects of the eggplant' calyx extract and its Solanum-inorganic hybrid nanoflower (Sm-ihNFs) via in vitro experimental Methods: The hybrid nanoflower was formed (NF) with organic molecules, eggplant extract (Sm), and inorganic compounds, copper to enhance the catalytic activities. The inhibition capacities of the eggplant extract, and its hybrid nanoflower were evaluated on selected enzymes (AGase, AAase, Tyr, AChE and BChE) which play significant roles physiologically by in vitro tests in this study. Results: According to inhibition percentages and IC50 values, Sm-ihNFs showed higher inhibitory activities on enzymes other than ache than the plain crude plant extract. Among all the enzymes that were studied, Sm-ihNFs demonstrated significantly higher alpha-glucosidase and alpha-amylase inhibition activities compared to acarbose. And when compared to galantamine hydrobromide Sm-ihNFs showed higher enzyme inhibition and significant IC50 value. Conclusion: It was thought that Sm-ihNFs prepared from eggplant extract may have promising potential for antidiabetic drug formulations in the future. The hybrid nanoflowers will be promising and guide for the future work in terms of pharmaceutical and cosmeceutical industry.
Açıklama
Anahtar Kelimeler
Solanum melongena, nanoflower, alpha-glucosidase amylase, tyrosinase, cholinesterases, Bioassay Guided Isolation, Solanum-Melongena, Alpha-Glucosidase, Aqueous Extract, In-Vitro, Antioxidant, Performance, Nanoflowers, Nanoparticles, Biosynthesis
Kaynak
Clinical And Experimental Health Sciences
WoS Q Değeri
N/A
Scopus Q Değeri
Cilt
14
Sayı
1
