Comparative study of chemical composition and the antimutagenic activity of propolis extracts obtained by means of various solvents

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dc.authoridSipahi, Nisa/0000-0001-8915-3545en_US
dc.authoridgoc rasgele, pınar/0000-0002-7558-3138en_US
dc.authorscopusid15136582600en_US
dc.authorscopusid57211212241en_US
dc.authorscopusid14008150300en_US
dc.authorwosidSipahi, Nisa/AAG-4583-2019en_US
dc.authorwosidgoc rasgele, pınar/S-8923-2016en_US
dc.contributor.authorRasgele, Pinar G.
dc.contributor.authorSipahi, Nisa
dc.contributor.authorYilmaz, Gulden
dc.date.accessioned2024-08-23T16:03:43Z
dc.date.available2024-08-23T16:03:43Z
dc.date.issued2023en_US
dc.departmentDüzce Üniversitesien_US
dc.description.abstractThe present study is aimed to evaluate the chemical characterization and antimutagenic potential of propolis extracted in three different solvents (ethanol, polyethylene glycol and water). The chemical properties of different extracts of propolis were identified using HPLC-DAD and LC- MS/MS and polyethylene glycol extract of propolis were found to be richer than the ethanolic and water extracts of propolis considering chemical composition. In addition, the antimutagenic activities of propolis extracts were determined using Ames assay. The concentrations of 3, 1.5 and 0.75 mg plate(-1) of ethanolic and polyethylene glycol extracts, as well as 0.3, 0.15 (sic) 0.075 mg plate(-1) of water extract of propolis were used as active materials. Propolis extracted in three different solvents indicated strong antimutagenic activity against both 4-nitro-o-phenylendiamine and sodium azide mutagens in the Salmonella typhimurium TA98 and 100 strains at all concentrations. Ethanolic extract of propolis had the highest inhibition rates for both bacterial strains and these rates were 98.94 and 97.37 % for TA98 and TA100, respectively. The inhibition rates of polyethylene glycol extract of propolis ranged from 68.27 to 98.94%. Moreover, it was determined that water extract of propolis had the lowest inhibition rates, which were 56.86 and 55.35% for TA98 and TA100, respectively. The toxicological safety of natural products such as propolis has gained great importance due to extensive usage.en_US
dc.identifier.doi10.2298/JSC230217027R
dc.identifier.endpage+en_US
dc.identifier.issn0352-5139
dc.identifier.issue6en_US
dc.identifier.scopus2-s2.0-85164807552en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage615en_US
dc.identifier.urihttps://doi.org/10.2298/JSC230217027R
dc.identifier.urihttps://hdl.handle.net/20.500.12684/13887
dc.identifier.volume88en_US
dc.identifier.wosWOS:001014943900001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherSerbian Chemical Socen_US
dc.relation.ispartofJournal of the Serbian Chemical Societyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectHPLC-DADen_US
dc.subjectames assayen_US
dc.subjectgenotoxicity testen_US
dc.subjectSalmonella typhimuriumen_US
dc.subjectPhenolic-Compoundsen_US
dc.subjectIn-Vitroen_US
dc.subjectLc-Ms/Msen_US
dc.subjectMutagenicityen_US
dc.subjectAntioxidanten_US
dc.titleComparative study of chemical composition and the antimutagenic activity of propolis extracts obtained by means of various solventsen_US
dc.typeArticleen_US

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