Evaluation of chromosomal abnormalities and common trombophilic mutations in cases with recurrent miscarriage

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dc.contributor.authorKarataş, Ahmet
dc.contributor.authorEröz, Recep
dc.contributor.authorAlbayrak, Mustafa
dc.contributor.authorÖzlü, Tülay
dc.contributor.authorÇakmak, Bülent
dc.contributor.authorKeskin, Fatih
dc.date.accessioned2020-05-01T12:11:57Z
dc.date.available2020-05-01T12:11:57Z
dc.date.issued2014
dc.departmentDÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.descriptionWOS: 000335444500034en_US
dc.descriptionPubMed: 26060483en_US
dc.description.abstractBackground: Recurrent miscarriage (RM) is a frequent obstetric problem. Its' pathophysiology is poorly understood. Infections, genetic, endocrine, anatomic and immunologic problems have been suggested as causes for RM. Objective: To evaluate the frequency of chromosomal abnormalities and 3 common thrombophilic mutations in couples with RM. Methods: A retrospective data collection was performed for the results of the cytogenetic analysis of the couples and Methylenetetrahydrofolate Reductase (MTHFR) C677T, Factor V Leiden (FVL) G1691A and Prothrombin (PTm) G20210A mutations of the mother in 142 couples suffering from RM. Results: Prevalence of FVL, MTHFR, and PTm gene mutations were similar between cases shaving 2 or >= 3 abortions (P=0.528; P=0.233; P=0.375). In patients with FVL, MTHFR and PTm gene mutations, the OR's of having >= 3 abortions when compared to having 2 abortions were 1.515 (95% CI: 0.414-5.552), 0.573 (95% CI: 0.228-1.441), and 2.848 (95% CI: 0.355-22.871). All cases with PTm mutation had >= 3 abortions and all abortions occurred between 6-8 gestational weeks. Conclusion: Chromosomal abnormalities and thrombophilic mutations (especially PTm) seem to have an important role in RM. Additional larger studies involving investigation of more genes that may have a role in pregnancy are needed to assess this association.en_US
dc.identifier.doi10.4314/ahs.v14i1.34en_US
dc.identifier.endpage222en_US
dc.identifier.issn1680-6905
dc.identifier.issn1729-0503
dc.identifier.issue1en_US
dc.identifier.startpage216en_US
dc.identifier.urihttps://doi.org/10.4314/ahs.v14i1.34
dc.identifier.urihttps://hdl.handle.net/20.500.12684/6302
dc.identifier.volume14en_US
dc.identifier.wosWOS:000335444500034en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherMakerere Univ, Fac Meden_US
dc.relation.ispartofAfrican Health Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectRecurrent miscarriageen_US
dc.subjectchromosomal abnormalitiesen_US
dc.subjectinherited thrombophilic polymorphismsen_US
dc.titleEvaluation of chromosomal abnormalities and common trombophilic mutations in cases with recurrent miscarriageen_US
dc.typeArticleen_US

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