Evaluation of the Relationship between Serum 25-Hydroxyvitamin D Levels and Pulmonary Functions in Adult Asthma
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Date
2020
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Abstract
Aim: This study was aimed to determine the relationship between serum 25-hydroxyvitaminD [25(OH)D] levels and the pulmonary functions in adult asthma patients.Material and Methods: A total of 131 asthmatic patients’ general characteristics, asthmasymptoms, pulmonary function test, asthma control test (ACT) scores, serum 25(OH)D levels,body weight, and height were recorded. Body mass indexes (BMIs) of the patients werecalculated and World Health Organization criteria were used for the classification. Patientswith serum 25(OH)D levels below 20 ng/mL were classified as having a deficiency, those with21-29 ng/mL as having an insufficiency, and those with 30 ng/mL and above as having normalserum vitamin D levels.Results: The serum 25(OH)D levels of patients in the uncontrolled asthma group, accordingto the ACT score, were found to be lower than those of patients in the controlled group(p=0.002). It was determined that as the serum 25(OH)D levels of the patients increased, theACT scores also increased significantly (r=0.280, p=0.001). Additionally it was found thateach 1 ng/mL increase in 25(OH)D level was associated with an increase of 0.176 L in forcedvital capacity (FVC). In addition it was determined that as the serum 25(OH)D levelsincreased, the patients’ FVCs also increased (OR=1.056, 95% CI=1.003-1.113, p=0.038).Although the change was not statistically significant (p=0.081), as serum 25(OH)D levelsincreased, the ACT scores also increased.Conclusion: Vitamin D insufficiency and deficiency were frequently found in adults withasthma and there was a relationship between vitamin D deficiency and pulmonary function.
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Volume
22
Issue
3
