Piperlongumine inhibits cell growth and enhances TRAIL-induced apoptosis in prostate cancer cells

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dc.authoridYurdakok-Dikmen, Begum/0000-0002-0385-3602
dc.authorwosidDikmen, Begum Yurdakok/AAX-2784-2020
dc.contributor.authorKismali, Gorkem
dc.contributor.authorCeylan, Ahmet
dc.contributor.authorMeral, Ogunc
dc.contributor.authorAlpay, Merve
dc.contributor.authorKosova, Funda
dc.contributor.authorCakir, Dilek Ulker
dc.contributor.authorSel, Tevhide
dc.date.accessioned2021-12-01T18:50:37Z
dc.date.available2021-12-01T18:50:37Z
dc.date.issued2020
dc.department[Belirlenecek]en_US
dc.description.abstractObjective: To investigate whether piperlongumine can sensitize prostate cancer cells to tumor necrosis factor-related apoptosis- inducing ligand (TRAIL) and trigger apoptosis in prostate cells. Methods: Human prostate cancer cell lines PC3, LNCaP, and VCaP were cultured with piperlongumine and TRAIL. Then, cell proliferation, migration, caspase activation, apoptotic protein expressions, and death receptor expressions were measured. Results: Piperlongumine inhibited cell proliferation at low doses (<10 mu M) alone and in combination with TRAIL (25 ng/mL), induced apoptosis, and suppressed cyclooxygenase activation. Additionally, piperlongumine induced expression of death receptors which potentiated TRAIL-induced apoptosis in cancer cells but did not affect decoy receptors. Piperlongumine also downregulated tumor cell-survival pathways, inhibited colony formation and migration of cancer cells alone or in combination with TRAIL. The combination of piperlongumine with TRAIL was found to be synergistic. Conclusions: Our findings indicate that piperlongumine can sensitize cancer cells to TRAIL through the upregulation of death receptors and can trigger apoptosis with the downregulation of anti- apoptotic proteins.en_US
dc.description.sponsorshipTurkish Scientific Council (TUBITAK)Turkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [115S942]en_US
dc.description.sponsorshipThis work was supported by the Turkish Scientific Council (TUBITAK), Grant#115S942.en_US
dc.identifier.doi10.4103/2221-1691.281465
dc.identifier.endpage223en_US
dc.identifier.issn2221-1691
dc.identifier.issn2588-9222
dc.identifier.issue5en_US
dc.identifier.scopus2-s2.0-85084237600en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage216en_US
dc.identifier.urihttps://doi.org/10.4103/2221-1691.281465
dc.identifier.urihttps://hdl.handle.net/20.500.12684/10902
dc.identifier.volume10en_US
dc.identifier.wosWOS:000530282000003en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherWolters Kluwer Medknow Publicationsen_US
dc.relation.ispartofAsian Pacific Journal Of Tropical Biomedicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectDeathen_US
dc.subjectRosen_US
dc.subjectMitochondriaen_US
dc.subjectActivationen_US
dc.subjectMechanismsen_US
dc.subjectPreventionen_US
dc.subjectMigrationen_US
dc.subjectMoleculeen_US
dc.subjectInvasionen_US
dc.subjectTherapyen_US
dc.titlePiperlongumine inhibits cell growth and enhances TRAIL-induced apoptosis in prostate cancer cellsen_US
dc.typeArticleen_US

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