Pre-purification of an Anticancer Drug (Paclitaxel) Obtained from Nut Husks

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dc.contributor.authorOğuzkan, Sibel Bayıl
dc.contributor.authorKaragül, Bora
dc.contributor.authorUzun, Ayşe
dc.contributor.authorGüler, Özen Özensoy
dc.contributor.authorUğraş, Halil İbrahim
dc.date.accessioned2020-04-30T23:21:32Z
dc.date.available2020-04-30T23:21:32Z
dc.date.issued2018
dc.departmentDÜ, Fen-Edebiyat Fakültesi, Kimya Bölümüen_US
dc.descriptionoguzkan, sibel Bayil/0000-0003-0254-6915en_US
dc.descriptionWOS: 000419160300009en_US
dc.description.abstractBackground and Objective: Hazelnut husk is known to contain taxanes, including paclitaxel. There are many methods for purifying paclitaxel, which is sold under the commercial brand name Taxol and is used as a chemotherapy medication. In this study, the effect of precipitation on the purity and yield of taxanes in the purification process of some taxane compounds from hazelnut husk was investigated by using different solvents. Materials and Methods: Collected, dried and milled samples of hazelnut husk were treated with methanol (1:15 g mL(-1)) at room temperature for 72 h in order to obtain extracts. The extraction process was repeated 20 times to achieve the desired concentrated stock solution. Each 1 mL sample taken from this stock solution was treated with four different solvents with various quantities of binary mixtures (1:5, 1:10 and 1:20) and then analyzed using HPLC (High-Performance Liquid Chromatography) following filtration. Results: The HPLC was used to determine both purity and recovery yield in the stock solution before and after the analysis. Baccatin III has the greatest purity among the paclitaxel derivatives as 10-Deacetylbaccatin III, baccatin III, cephalomannine and paclitaxel, that were evaluated in the present study. Conclusion: Thus, the effects of precipitation from extracts containing taxane compounds derived from the hazelnut husk were determined in the pre-chromatographic purification processes.en_US
dc.description.sponsorshipScientific and Technological Research Council of Turkey (TUBITAK)Turkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [114Z233]en_US
dc.description.sponsorshipAuthors would like to thank the Scientific and Technological Research Council of Turkey (TUBITAK) for financial support (Grant No. 114Z233).en_US
dc.identifier.doi10.3923/ijp.2018.76.82en_US
dc.identifier.endpage82en_US
dc.identifier.issn1811-7775
dc.identifier.issn1812-5700
dc.identifier.issue1en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage76en_US
dc.identifier.urihttps://doi.org/10.3923/ijp.2018.76.82
dc.identifier.urihttps://hdl.handle.net/20.500.12684/4209
dc.identifier.volume14en_US
dc.identifier.wosWOS:000419160300009en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherAsian Network Scientific Information-Ansineten_US
dc.relation.ispartofInternational Journal Of Pharmacologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectTaxanen_US
dc.subjectpaclitaxelen_US
dc.subject10-Deacetylbaccatinen_US
dc.subjectbaccatin IIIen_US
dc.subjectcephalomannineen_US
dc.titlePre-purification of an Anticancer Drug (Paclitaxel) Obtained from Nut Husksen_US
dc.typeArticleen_US

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