Lipoprotein(a) is associated with coronary heart disease independent of metabolic syndrome

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dc.contributor.authorOnat, Altan
dc.contributor.authorHergenç, Gülay
dc.contributor.authorÖzhan, Hakan
dc.contributor.authorKaya, Zekeriya
dc.contributor.authorBulur, Serkan
dc.contributor.authorAyhan, Erkan
dc.contributor.authorCan, Günay
dc.date.accessioned2020-04-30T23:18:56Z
dc.date.available2020-04-30T23:18:56Z
dc.date.issued2008
dc.departmentDÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.descriptionWOS: 000255571200001en_US
dc.descriptionPubMed: 18418227en_US
dc.description.abstractAim To assess (i) the association between lipoprotein(a) [Lp(a)] with the likelihood of coronary heart disease and metabolic syndrome (MS) and (ii) its covariates in Turkish adults. Methods Cross-sectional evaluation of 1309 adults, who had serum Lp(a) determinations by Behring nephelometry, and followed for a mean 1.0 year. MS was defined by ATPIII criteria modified for male abdominal obesity. Results Mean age of the sample was 56.8 +/- 11.3 years. After adjustment for sex, age, and smoking status, log-transformed Lp(a) levels were associated significantly with coronary heart disease likelihood in both sexes combined [odds ratio: 1.53 (95% confidence interval: 1.06; 2.20)]. This association persisted after additional adjustment for MS [odds ratio: 1.57 (95% confidence interval: 1.09; 2.26)]. The Lp(a) mid-tertile (5-17 mg/dl), accompanied by significantly lower serum triglycerides than the two remaining tertiles, was inversely associated significantly with MS in either sex; in women, this association was independent of waist circumference. In a linear regression comprising seven variables, excepting total cholesterol, only gamma-glutamyltransferase in women (P=0.002) and waist circumference (P=0.057) in men were inverse covariates of modest magnitude of Lp(a). Conclusion Coronary heart disease likelihood, significantly associated with Lp(a) concentrations, is independent of MS and insulin resistance. Suggestive evidence was provided that intermediary Lp(a) concentrations, when accompanied by the presence of MS, could accelerate progression of vascular disease, especially in women.en_US
dc.identifier.doi10.1097/MCA.0b013e3282f399cfen_US
dc.identifier.endpage131en_US
dc.identifier.issn0954-6928
dc.identifier.issn1473-5830
dc.identifier.issue3en_US
dc.identifier.startpage125en_US
dc.identifier.urihttps://doi.org/10.1097/MCA.0b013e3282f399cf
dc.identifier.urihttps://hdl.handle.net/20.500.12684/3591
dc.identifier.volume19en_US
dc.identifier.wosWOS:000255571200001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherLippincott Williams & Wilkinsen_US
dc.relation.ispartofCoronary Artery Diseaseen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectcoronary heart diseaseen_US
dc.subjectinsulin resistanceen_US
dc.subjectlipoprotein(a)en_US
dc.subjectmetabolic syndromeen_US
dc.titleLipoprotein(a) is associated with coronary heart disease independent of metabolic syndromeen_US
dc.typeArticleen_US

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