Combination of Biochemical and Cytological Findings for Better Diagnosis in Pleural Effusions

Basit Öğe Kaydı
dc.authorscopusid57219950134
dc.authorscopusid6508107360
dc.authorscopusid7003794103
dc.authorscopusid7202545664
dc.authorscopusid57212619932
dc.authorscopusid6506302742
dc.authorscopusid55828366200
dc.contributor.authorElmas, Hatice
dc.contributor.authorBiancosino, Christian
dc.contributor.authorÖnal, Binnur
dc.contributor.authorSchmitt, Fernando
dc.contributor.authorBüyücek, Şeyma
dc.contributor.authorNordholt, Gerhard
dc.contributor.authorSauter, Guido
dc.date.accessioned2023-07-26T11:50:56Z
dc.date.available2023-07-26T11:50:56Z
dc.date.issued2022
dc.departmentDÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Tıbbi Patoloji Ana Bilim Dalıen_US
dc.description.abstractSerous pleural effusions result from increased permeability and changed hydrostatic or colloid osmotic pressure. Laboratory biochemical findings provide conclusions about the effusion compositions. Together with the anamnesis and clinical assessment, they enable the evaluation of the effusion nature. The present study retrospectively analyzed combined biochemical and morphological findings in 2307 effusions of patients from two clinical centers: LungenClinic Grosshansdorf in Germany and Duzce University in Turkey. The effusion cytology results of 1771 and 536 patients from the respective centers were combined with clinical/radiological/biochemical findings and counter compared with the final diagnoses. Cytology verified 738 malignant tumors (643 and 95, respectively). Most effusions were benign (n = 1569; 77%) and 367 of them were paramalignant (293 and 74, respectively) and 594 were inflammatory (465 and 129, respectively). There was a distinctly lower number of malignant tumors in transudates than exudates (87 vs. 725; p < 0.0001). Squamous cell carcinoma was more frequent in paramalignant pleura effusions (122 cases out of the 367 effusions) than pleural carcinomatosis (32 cases out of the 780 malignant tumors; p < 0.0001). The cell formula was a suitable marker for malignant mesothelioma, predominantly mesothelial, or neutrophilic characterized by elevated LDH (>500 U/L) in the early stage of empyema or its late manifestation. İn conclusion, most effusions are benign. Cytologists, assisted by clinical and biochemical data and microscopic findings, can make significant differential diagnostic contributions beyond the sole detection of malignancy. © 2022, The Author(s), under exclusive license to Springer Nature Switzerland AG.en_US
dc.identifier.doi10.1007/5584_2021_703
dc.identifier.endpage62en_US
dc.identifier.issn0065-2598
dc.identifier.pmid35147931en_US
dc.identifier.scopus2-s2.0-85127890926en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage51en_US
dc.identifier.urihttps://doi.org/10.1007/5584_2021_703
dc.identifier.urihttps://hdl.handle.net/20.500.12684/12460
dc.identifier.volume1374en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorÖnal, Binnur
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofAdvances in Experimental Medicine and Biologyen_US
dc.relation.publicationcategoryKitap Bölümü - Uluslararasıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmz$2023V1Guncelleme$en_US
dc.subjectBenign diseasesen_US
dc.subjectBiochemistryen_US
dc.subjectCytologyen_US
dc.subjectMalignancyen_US
dc.subjectPleural effusionen_US
dc.subjectTumorsen_US
dc.subjectageden_US
dc.subjectbiochemical analysisen_US
dc.subjectclinical examinationen_US
dc.subjectclinical featureen_US
dc.subjectcontrolled studyen_US
dc.subjectcytopathologyen_US
dc.subjectdiagnostic valueen_US
dc.subjectdifferential diagnosisen_US
dc.subjectfemaleen_US
dc.subjectGermanyen_US
dc.subjecthumanen_US
dc.subjecthuman cellen_US
dc.subjecthuman tissueen_US
dc.subjectmajor clinical studyen_US
dc.subjectmaleen_US
dc.subjectmesotheliomaen_US
dc.subjectpleura effusionen_US
dc.subjectpleura empyemaen_US
dc.subjectpleura malignancyen_US
dc.subjectretrospective studyen_US
dc.subjectsquamous cell lung carcinomaen_US
dc.subjectthorax radiographyen_US
dc.subjectTurkey (republic)en_US
dc.subjectmalignant pleura effusionen_US
dc.subjectpathologyen_US
dc.subjectpleura tumoren_US
dc.subjectsquamous cell carcinomaen_US
dc.subjectCarcinoma, Squamous Cellen_US
dc.subjectDiagnosis, Differentialen_US
dc.subjectHumansen_US
dc.subjectPleural Effusionen_US
dc.subjectPleural Effusion, Malignanten_US
dc.subjectPleural Neoplasmsen_US
dc.subjectRetrospective Studiesen_US
dc.titleCombination of Biochemical and Cytological Findings for Better Diagnosis in Pleural Effusionsen_US
dc.typeBook Chapteren_US

Dosyalar

Koleksiyon

Scopus İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu