Oxidative, Genotoxic and Cytotoxic Damage Potential of Novel Borenium and Borinium Compounds

Basit Öğe Kaydı
dc.authoridugras, halil ibrahim/0000-0002-1633-967Xen_US
dc.authoridMardinoglu, Adil/0000-0002-4254-6090en_US
dc.authoridBayil oguzkan, sibel/0000-0003-0254-6915en_US
dc.authorscopusid58035956100en_US
dc.authorscopusid9134233800en_US
dc.authorscopusid6603474174en_US
dc.authorscopusid6602799699en_US
dc.authorscopusid24484791900en_US
dc.authorwosidugras, halil ibrahim/KSM-2767-2024en_US
dc.contributor.authorOguzkan, Sibel Bayil
dc.contributor.authorTurkez, Hasan
dc.contributor.authorUgras, Halil Ibrahim
dc.contributor.authorTatar, Arzu
dc.contributor.authorMardinoglu, Adil
dc.date.accessioned2024-08-23T16:03:36Z
dc.date.available2024-08-23T16:03:36Z
dc.date.issued2023en_US
dc.departmentDüzce Üniversitesien_US
dc.description.abstractIn this study, the biological properties of novel borenium and borinium compounds in terms of their oxidative, genotoxic, and cytotoxic effects were assessed on cultured human peripheral blood cells, as well as several types of cancer cells. Our results revealed that the borinium compounds yielded the best results in terms of supporting total antioxidant capacity (TAC). In fact, borenium 1, borenium 2, borenium 3, borinium 4, and borinium 5 compounds elevated TAC levels of cultured human blood cells at rates of 42.8%, 101.5%, 69.8%, 33.3%, and 49.2%, respectively. There were no statistically significant differences (p > 0.05) between the negative control and the groups treated with all borinium and borenium concentrations from the micronucleus (MN) and chromosome aberration (CA) assays, demonstrating the non-genotoxic effects. Moreover, borenium 1 (60.7% and 50.7%), borenium 2 (70.4% and 57.2%), borenium 3 (53.1% and 45.2%), borinium 4 (55.1% and 48.1%), and borinium 5 (51.0% and 36.1%) minimized the mitomycin C(MMC)-induced genotoxic damages at different rates as determined using CA and MN assays, respectively. Again, it was found that the borinium compounds exhibited higher cytotoxic activity on cancer cells when compared to borenium compounds. Consequently, in light of our in vitro findings, it was suggested that the novel borinium and borenium compounds could be used safely in pharmacology, cosmetics, and various medical fields due to their antioxidant and non-genotoxic features, as well as their cytotoxicity potential on cancer cells.en_US
dc.description.sponsorshipThe synthesis of the compounds was obtained with the results of the TUBITAK project with the code number 114M933.; [114M933]en_US
dc.description.sponsorshipThe synthesis of the compounds was obtained with the results of the TUBITAK project with the code number 114M933.en_US
dc.identifier.doi10.3390/inorganics11080324
dc.identifier.issn2304-6740
dc.identifier.issue8en_US
dc.identifier.scopus2-s2.0-85169054736en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.3390/inorganics11080324
dc.identifier.urihttps://hdl.handle.net/20.500.12684/13816
dc.identifier.volume11en_US
dc.identifier.wosWOS:001056218200001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherMdpien_US
dc.relation.ispartofInorganicsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectantioxidanten_US
dc.subjectantigenotoxicityen_US
dc.subjectboron compoundsen_US
dc.subjectboreniumen_US
dc.subjectboriniumen_US
dc.subjectcancer cellsen_US
dc.subjectcytotoxicityen_US
dc.subjecthuman blood cellsen_US
dc.subjectgenotoxicityen_US
dc.subjectDouble-Strand Breaksen_US
dc.subjectBoron-Compoundsen_US
dc.subjectFormulationen_US
dc.subjectGrowthen_US
dc.titleOxidative, Genotoxic and Cytotoxic Damage Potential of Novel Borenium and Borinium Compoundsen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu