The relationship between echocardiographic features of mitral valve and elastic proporties of aortic wall and Beighton hypermobility score in patients with mitral valve

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dc.contributor.authorYazıcı, Mehmet
dc.contributor.authorAtaoğlu, Safinaz
dc.contributor.authorMakarç, Sevim
dc.contributor.authorSarı, İbrahim
dc.contributor.authorErbilen, Enver
dc.contributor.authorAlbayrak, Sinan
dc.contributor.authorUyan, Cihangir
dc.date.accessioned2020-04-30T23:34:14Z
dc.date.available2020-04-30T23:34:14Z
dc.date.issued2004
dc.departmentDÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.descriptionWOS: 000223527600009en_US
dc.descriptionPubMed: 15240965en_US
dc.description.abstractThe present study was designed to investigate the incidence of benign joint hypermobility syndrome (BJHMS) in mitral valve prolapse (MVP) and the correlation between the echocardiographic features of the mitral valve and elastic properties of the aortic wall and Beighton hypermobility score (BHS) in patients with MVP and BJHMS. Fourty-six patients with nonrheumatic, uncomplicated, and isolated mitral anterior leaflet prolapse (7 men and 39 women, mean age; 26.1 +/- 5.9) and 25 healthy subjects (3 men and 22 women, mean age, 25.4 +/- 4.3) were Studied. Patients were divided into two groups according to their BHS (group I, MVP+BJHMS; group II, MVP-BJHMS). Individuals with accompanying cardiac or systemic disease were excluded. Echocardiographic examination was performed in all subjects. The presence of BJHMS was evaluated according to Beighton's criteria. The incidence of BJHMS in patients with MVP was found to be significantly higher than that of controls (45.6%, (21/46) vs 12% (3/25), P < 0.0001). Group I (MVP + BJHMS) had significantly increased anterior mitral leaflet thickness (AMLT, 3.4 +/- 0.4 vs 3.1 +/- 0.3; P < 0.005), maximal leaflet displacement (MLD, 2.4 +/- 0.4 vs 1.7 +/- 0.4; P < 0.005), and degree of mitral regurgitation (DMR, 17.1 +/- 7.2 vs 11.2 +/- 4.4; P < 0.01) compared to group II. However, the index of aortic stiffness (IAOS) was found to be lower (17.6 +/- 6.9 vs 23.9 +/- 7.6; P < 0.005) and aortic distensibility (AOD) to be higher (0.0035 +/- 0.007 vs 0.0024 +/- 0.005; P < 0.005) in group I. There was a significant correlation between AMLT, MLD and DMR, and BHS (r = 0.57/P = 0.007, r = 0.55/P < 0.009, r = 0.51/P < 0.01, respectively). In addition, AOD correlated positively with BHS (r = 0.53/ P < 0.005), but the index of aortic stiffness correlated inversely with BHS (r = -0.49/P < 0.007). The incidence of BJHMS in patients with MVP was more frequent than the normal population and there was a significant correlation between the severity of BJHMS (according to BHS) and echocardiographic features of the mitral leaflets and elastic properties of the aortic wall.en_US
dc.identifier.doi10.1536/jhj.45.447en_US
dc.identifier.endpage460en_US
dc.identifier.issn0021-4868
dc.identifier.issue3en_US
dc.identifier.startpage447en_US
dc.identifier.urihttps://doi.org/10.1536/jhj.45.447
dc.identifier.urihttps://hdl.handle.net/20.500.12684/5126
dc.identifier.volume45en_US
dc.identifier.wosWOS:000223527600009en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherJapan Heart Journal, Second Dept Of Internal Meden_US
dc.relation.ispartofJapanese Heart Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectmitral valve prolapseen_US
dc.subjectbenign joint hypermobility syndromeen_US
dc.titleThe relationship between echocardiographic features of mitral valve and elastic proporties of aortic wall and Beighton hypermobility score in patients with mitral valveen_US
dc.typeArticleen_US

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