Aquasomes: a novel platform for drug delivery
Küçük Resim Yok
Tarih
2022
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Elsevier
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
In recent years, drug research has focused on nanocarrier systems. Self-assembled nanodrug delivery systems such as liposome, niosome, polymersome, and transfersome maintain their popularity as drug research subjects. Aquasomes are also in the class of self-assembled drug delivery systems, but they are not vesicular systems. Aquasomes are formed by the coating of polyhydroxyl oligomers on a solid crystal core. The drug is adsorbed on this oligomer layer, and a three-layer structure is obtained. Aquasomes have two important advantages over other nanoparticular systems. First, the crystal core increases the stability of the particle, and second, the carbohydrate layer provides the appropriate layer for the active substance to be adsorbed. In addition, although it is stated in the literature that it is generally suitable for the delivery of biological molecules such as proteins, antigens, and nucleic acids, since it is a system that can protect the active pharmaceutical ingredient against dehydration, there are also studies for some small molecule drugs. © 2022 Elsevier Inc. All rights reserved.
Açıklama
Anahtar Kelimeler
Aquasomes, bodies of water, brushite, calcium phosphate, ceramic core, ceramic nanoparticles, nanocarriers, oligomers, self-assembling nanocarrier, targeted drug delivery
Kaynak
Systems of Nanovesicular Drug Delivery
