Role of Protocatechuic Acid (PCA) on Hepatoxicity and Nephrotoxicity Induced by 2, 3, 7, 8-Tetracholorodibenzo-P-Dioxin (TCDD) in Rats
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Tarih
2020
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info:eu-repo/semantics/openAccess
Özet
It is known that TCDD, one of the most toxic dioxin compounds, causes oxidative damage by forming free radicalin human and animal tissues. In this study, the protective effect of PCA, an important phenolic compound, wasexamined in rat kidney and liver tissues with TCDD-induced toxicity. For this purpose, 28 Wistar Albino rats (3-4 months old and weighing 280-310 g) were used. Rats were randomly divided into 4 equal groups (control, TCDD,PCA and TCDD+PCA). TCDD and PCA were dissolved in corn oil at doses of 2 µg/kg and 100 mg/kg,respectively. Subsequently, the substances were administered to the rats by oral gavage for 45 days. The test resultsshowed that in both kidney and liver tissues, TCDD increased the level of malondialdehyde (MDA) but inhibitedthe level of glutathione (GSH) and the activities of superoxide dismutase (SOD), catalase (CAT) and glutathioneperoxidase (GSH-Px). PCA administration was found to increase the enzyme activities and GSH levels, whereasit decreased the TCDD and MDA levels. In conclusion, it was observed that PCA decreased the TCDD-inducedlipid peroxidation, increasing the antioxidant activity. Therefore, it might be suggested that PCA is a potentialreducing agent for the toxicity caused by TCDD.
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Düzce Üniversitesi Bilim ve Teknoloji Dergisi
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8
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1
