Novel Tetrazole And 1,3,4-Oxadiazole Derivatives Synthesis, Molecular Docking, Adme, Potential Activator For Rabbit Muscle Pyruvate Kinase

Basit Öğe Kaydı
dc.contributor.authorKaya, Mustafa Oguzhan
dc.contributor.authorDemirci, Tuna
dc.contributor.authorKaripcin, Selman
dc.contributor.authorOzdemir, Oguzhan
dc.contributor.authorKaya, Yesim
dc.contributor.authorArslan, Mustafa
dc.date.accessioned2024-08-23T16:07:21Z
dc.date.available2024-08-23T16:07:21Z
dc.date.issued2024en_US
dc.departmentDüzce Üniversitesien_US
dc.description.abstract. The activation of muscle pyruvate kinase (PK) increases the conversion of phosphoenolpyruvate (PEP) to pyruvate, which results in the production of ATP. This is critical for supplying the energy needed for muscle contraction. In this study, we synthesized 1,4-dihydropyridine/pyridine compounds bearing tetrazole and 1,3,4-oxadiazole groups by using Hantzsch method and characterized by FT-IR spectroscopy, elemental analysis, and The studies revealed that all original synthesized compounds activated PK and AC50 (half-maximal activating concentration) values of the compounds were extremely effective (1.30 mu M to 14.65 mu M).en_US
dc.description.sponsorshipSCIENTIFIC AND TECHNOLOGICAL RESEARCH INSTITUTION OF TURKEY (TUBITAK)en_US
dc.description.sponsorshipThis work was supported by a SCIENTIFIC AND TECHNOLOGICAL RESEARCH INSTITUTION OF TURKEY (TUBITAK) 2209 Project Synthesis of Penta Substituted Pyridine Compounds Containing Alkyl/Aryl and Amino Oxadiazole in the 5 -Position.en_US
dc.identifier.issn1224-7154
dc.identifier.issue1en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12684/14616
dc.identifier.volume69en_US
dc.identifier.wosWOS:001223493500004en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherUniv Babes-Bolyaien_US
dc.relation.ispartofStudia Universitatis Babes-Bolyai Chemiaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectRabbit Muscle Pyruvate Kinaseen_US
dc.subjectTetrazoleen_US
dc.subject1,3,4-oxadiazoleen_US
dc.subjectDrug Discoveryen_US
dc.subjectLumo Analysisen_US
dc.subjectIn-Silicoen_US
dc.subjectM2en_US
dc.subjectChemistryen_US
dc.subjectMetabolismen_US
dc.subjectDesignen_US
dc.subjectRamanen_US
dc.subjectHomoen_US
dc.subjectToolen_US
dc.titleNovel Tetrazole And 1,3,4-Oxadiazole Derivatives Synthesis, Molecular Docking, Adme, Potential Activator For Rabbit Muscle Pyruvate Kinaseen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu