Novel Tetrazole And 1,3,4-Oxadiazole Derivatives Synthesis, Molecular Docking, Adme, Potential Activator For Rabbit Muscle Pyruvate Kinase
Küçük Resim Yok
Tarih
2024
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Univ Babes-Bolyai
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
. The activation of muscle pyruvate kinase (PK) increases the conversion of phosphoenolpyruvate (PEP) to pyruvate, which results in the production of ATP. This is critical for supplying the energy needed for muscle contraction. In this study, we synthesized 1,4-dihydropyridine/pyridine compounds bearing tetrazole and 1,3,4-oxadiazole groups by using Hantzsch method and characterized by FT-IR spectroscopy, elemental analysis, and The studies revealed that all original synthesized compounds activated PK and AC50 (half-maximal activating concentration) values of the compounds were extremely effective (1.30 mu M to 14.65 mu M).
Açıklama
Anahtar Kelimeler
Rabbit Muscle Pyruvate Kinase, Tetrazole, 1,3,4-oxadiazole, Drug Discovery, Lumo Analysis, In-Silico, M2, Chemistry, Metabolism, Design, Raman, Homo, Tool
Kaynak
Studia Universitatis Babes-Bolyai Chemia
WoS Q Değeri
N/A
Scopus Q Değeri
Cilt
69
Sayı
1
