Decreased Uric Acid and Phosphorus Levels in Active Juvenile Systemic Lupus Erythematosus

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dc.contributor.authorSav, Nadide Melike
dc.contributor.authorBilal, Yıldız
dc.contributor.authorÇetin, Nuran
dc.date.accessioned2023-07-26T11:55:13Z
dc.date.available2023-07-26T11:55:13Z
dc.date.issued2022
dc.departmentDÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Çocuk Sağlığı ve Hastalıkları Ana Bilim Dalıen_US
dc.description.abstractIntroduction: The aim of the present study was to investigate serum phosphate and uric acid levels (UA) in juvenile sys- temic lupus erythematosus (jSLE) and to ascertain their relationship, if any, with disease activity and lupus nephritis. Methods: Included in the study were 18 children with jSLE who were investigated retrospectively during the active phase (AP) and remission phase (RP) of jSLE. Results: Serum phosphate and UA levels were found to be significantly lower in AP than in the RP (2.5±0.3/4.2±0.08 mg/dL, p=0.0001 and 2.9±0.3/5±0.2 mg/dL, p=0.0001, respectively). Serum phosphate levels were strongly correlated with serum albumin levels (r=0.772, p=0.0001) and platelet count (r=0.735, p=0.001) and negative associated with D-dimer (r=?0.750, p=0.0001) in AP. No correlation was identified between serum phosphate and UA or creatinine levels in patients with AP, while serum phosphate and UA levels were similar in children with and without nephritis (p>0.05). Serum phosphate lev- els were correlated with platelet count and UA levels and were inversely related with D-dimer levels in jSLE patients with nephritis (p<0.05). Discussion and Conclusion: Serum phosphate and UA levels can reflect the activation and low serum levels may be useful biomarkers for the detection of AP in jSLE patients with and without nephritis.en_US
dc.identifier.doi10.14744/hnhj.2022.16779
dc.identifier.endpage314en_US
dc.identifier.issn2630-5720
dc.identifier.issue3en_US
dc.identifier.startpage307en_US
dc.identifier.trdizinid1126845en_US
dc.identifier.urihttp://doi.org/10.14744/hnhj.2022.16779
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/1126845
dc.identifier.urihttps://hdl.handle.net/20.500.12684/13025
dc.identifier.volume62en_US
dc.indekslendigikaynakTR-Dizinen_US
dc.institutionauthorSav, Nadide Melike
dc.language.isoenen_US
dc.relation.ispartofHaydarpaşa Numune Medical Journalen_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmz$2023V1Guncelleme$en_US
dc.titleDecreased Uric Acid and Phosphorus Levels in Active Juvenile Systemic Lupus Erythematosusen_US
dc.typeArticleen_US

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