Decreased Uric Acid and Phosphorus Levels in Active Juvenile Systemic Lupus Erythematosus
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Tarih
2022
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info:eu-repo/semantics/openAccess
Özet
Introduction: The aim of the present study was to investigate serum phosphate and uric acid levels (UA) in juvenile sys- temic lupus erythematosus (jSLE) and to ascertain their relationship, if any, with disease activity and lupus nephritis. Methods: Included in the study were 18 children with jSLE who were investigated retrospectively during the active phase (AP) and remission phase (RP) of jSLE. Results: Serum phosphate and UA levels were found to be significantly lower in AP than in the RP (2.5±0.3/4.2±0.08 mg/dL, p=0.0001 and 2.9±0.3/5±0.2 mg/dL, p=0.0001, respectively). Serum phosphate levels were strongly correlated with serum albumin levels (r=0.772, p=0.0001) and platelet count (r=0.735, p=0.001) and negative associated with D-dimer (r=?0.750, p=0.0001) in AP. No correlation was identified between serum phosphate and UA or creatinine levels in patients with AP, while serum phosphate and UA levels were similar in children with and without nephritis (p>0.05). Serum phosphate lev- els were correlated with platelet count and UA levels and were inversely related with D-dimer levels in jSLE patients with nephritis (p<0.05). Discussion and Conclusion: Serum phosphate and UA levels can reflect the activation and low serum levels may be useful biomarkers for the detection of AP in jSLE patients with and without nephritis.
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Kaynak
Haydarpaşa Numune Medical Journal
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Cilt
62
Sayı
3
