Evaluation of dexamethasone suppression test in fibromyalgia patients with or without depression

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dc.contributor.authorAtaoğlu, Safinaz
dc.contributor.authorÖzçetin, Adnan
dc.contributor.authorYıldız, Özcan
dc.contributor.authorAtaoğlu, Ahmet
dc.date.accessioned2020-05-01T12:11:57Z
dc.date.available2020-05-01T12:11:57Z
dc.date.issued2003
dc.departmentDÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.descriptionWOS: 000183769800004en_US
dc.descriptionPubMed: 12811674en_US
dc.description.abstractObjective: While in most healthy persons dexamethasone administration suppresses cortisol synthesis from the adrenal cortex, such suppression is not usually observed in patients with depression. We set out to investigate whether the dexamethasone suppression test (DST) reveals any neurobiological relationship between fibromyalgia (FM) and depression related to the hypothalamic-pituitary-adrenal (HPA) axis. Method. To discover a relationship between depression and FM we performed the DST in 2 0 FM patients with depression, 26 FM patients without depression and 20 healthy subjects serving as a control group. Results: Compared with the control group the cortisol level was found to be significantly higher in response to the DST in FM patients with depression (p = 0.03; z: -2.165), but not in those without depression (p = 0.15 3 ; z: -1.429). The cortisol level was not found to be statistically significant when patients with FM without depression were compared with the control group (p = 0.249 z: -1.152). In 7 FM patients with depression the DST failed to suppress cortisol; this was statistically significant compared with FM patients without depression (p = 0.014) and the control group (p = 0.008). Among FM patients without depression cortisol was not suppressed in one case. Cortisol was suppressed in all the controls. There was no statistically significant difference in cortisol suppression between FM patients without depression and the control group (p = 1.00). Conclusion: Our findings show that the DST reveals no neurobiological relationship between FM and depression related to the HPA axis.en_US
dc.identifier.endpage244en_US
dc.identifier.issn1424-7860
dc.identifier.issue15-16en_US
dc.identifier.startpage241en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12684/6310
dc.identifier.volume133en_US
dc.identifier.wosWOS:000183769800004en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherE M H Swiss Medical Publishers Ltden_US
dc.relation.ispartofSwiss Medical Weeklyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectfibromyalgiaen_US
dc.subjectdepressionen_US
dc.subjectdexamethasone suppression testen_US
dc.titleEvaluation of dexamethasone suppression test in fibromyalgia patients with or without depressionen_US
dc.typeArticleen_US

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