Cytotoxicity of arene ruthenium metalla-rectangles incorporating bis-pyridyl diimide linkers

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dc.contributor.authorOrhan, Ersin
dc.contributor.authorGarci, Amine
dc.contributor.authorRiedel, Tina
dc.contributor.authorDyson, Paul J.
dc.contributor.authorTherrien, Bruno
dc.date.accessioned2020-05-01T09:11:16Z
dc.date.available2020-05-01T09:11:16Z
dc.date.issued2016
dc.departmentDÜ, Fen-Edebiyat Fakültesi, Kimya Bölümüen_US
dc.descriptionDyson, Paul/0000-0003-3117-3249; Therrien, Bruno/0000-0002-0388-2745en_US
dc.descriptionWOS: 000376387100007en_US
dc.description.abstractA series of tetranuclear arene ruthenium complexes of the general formula [Ru-4(p-cymene)(4)(mu(2)-L)(2)(mu(4)-OO boolean AND OO)(2)][CF3SO3](4) (L-1 = N,N'-bis(4-pyridylmethyl)-pyromellitic diimide, L-2 = N,N'-bis(4-pyridylmethyl)-naphthalene diimide) were obtained from the corresponding dinuclear arene ruthenium complexes Ru-2(p-cymene)(2)(mu 4-OO boolean AND OO)Cl-2 (OO boolean AND OO = oxalato (oxa), 2,5-dioxido-1,4-benzoquinonato (dobq), 2,5-dihydroxy-3-phenyl-1,4-benzoquinonato (dhpb), 2,5-dichloro-1,4-benzoquinonato (dClbq), 2,5-dioxido-3-undecyl-1,4-benzoquinonato (dubq), 2,5-dihydroxy-3,6-diphenyl-1,4-benzoquinonato (dhdb), 5,8-dioxido-1,4-naphtoquinonato (donq)) by reaction with the bidentate ligands (L-1 and L-2) and silver trifluoromethanesulfonate. The antiproliferative activity of the tetranuclear arene ruthenium metalla-rectangles was evaluated on cancerous (A2780 and A2780cisR) and non-cancerous (HEK293) cell lines, showing in all cases cancer cell selectivity. In general, the metalla-rectangles obtained with L-2 are more potent than those incorporating L-1, and with the exception of [Ru-4(p-cymene)(4)(mu(2)-L-1)(2)(m(4)-dClbq)(2)][CF3SO3](4), they are all more active than cisplatin on the cisplatin resistant A2780cisR cell line. (C) 2016 Elsevier B.V. All rights reserved.en_US
dc.description.sponsorshipUniversity of Neuchatelen_US
dc.description.sponsorshipE. O. thanks the Duzce University for a sabbatical leave and the University of Neuchatel for financial support.en_US
dc.identifier.doi10.1016/j.jorganchem.2016.05.004en_US
dc.identifier.endpage58en_US
dc.identifier.issn0022-328X
dc.identifier.issn1872-8561
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage53en_US
dc.identifier.urihttps://doi.org/10.1016/j.jorganchem.2016.05.004
dc.identifier.urihttps://hdl.handle.net/20.500.12684/5454
dc.identifier.volume815-816en_US
dc.identifier.wosWOS:000376387100007en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherElsevier Science Saen_US
dc.relation.ispartofJournal Of Organometallic Chemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBioorganometallic chemistryen_US
dc.subjectSupramolecular chemistryen_US
dc.subjectArene ruthenium complexesen_US
dc.subjectMetalla-assembliesen_US
dc.subjectMetal-based drugsen_US
dc.subjectHalf-sandwich complexesen_US
dc.titleCytotoxicity of arene ruthenium metalla-rectangles incorporating bis-pyridyl diimide linkersen_US
dc.typeArticleen_US

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