Exploring of the ameliorative effects of ethanolic extract of the wheatgrass (Triticumaestivum l.) On surgically induced endometriosis rat model

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dc.authoridADIYAMAN, ABDULLAH/0000-0002-3049-9813en_US
dc.authorscopusid57223186853en_US
dc.authorscopusid25121451300en_US
dc.authorscopusid56020070400en_US
dc.authorwosidBattal, Abdulhamit/JFS-6886-2023en_US
dc.contributor.authorAdiyaman, Abdullah
dc.contributor.authorBattal, Abdulhamit
dc.contributor.authorIlhan, Mert
dc.date.accessioned2024-08-23T16:03:39Z
dc.date.available2024-08-23T16:03:39Z
dc.date.issued2023en_US
dc.departmentDüzce Üniversitesien_US
dc.description.abstractThe purpose of this study was to investigate the healing effects of an ethanolic wheatgrass (WG) extract obtained from young wheat leaves on a surgically induced endometriosis rat model. 30 female Wistar albino rats with endometriosis were randomly organized into five groups (N = 6): Control, Letrozole a reference drug for endometriosis (0.2 mg/kg/day), WG-25 (25 mg/kg/day WG extract), WG-100 (100 mg/kg/day WG extract) and WG-400 (400 mg/kg/day WG extract). WG-100 extract and Letrozole caused a significantly decrease in adhesion score compared to the control. Additionally, treatment with WG extracts resulted in a significant reduction of endometrial cyst volumes compared to the control group. IL-6 cytokine levels in peritoneal fluid of WG-100 and Letrozole groups were importantly lower than the control. Matrix metallopeptidase 9, VEGF and kinase insert domain receptor genes were expressed in endometrial cysts. According to LC-MS/MS analysis, aconitic acid was the major phenolic acid (54.004 mg analyte/g extract) in the WG extract. Additionally, quinic acid (3.687 mg analyte/g extract) and protocatechuic acid (0.014 mg analyte/g extract) were determined in the WG extract. Moreover, the WG extract had vitamin E (5.49 +/- 0.08 mg/g extract) and vitamin C (7.42 +/- 0.13 mg/g extract). As conclusion, WG extract obtained from young leaves of wheat has ameliorative effects on surgically induced endometriosis due to its rich phytochemical content.en_US
dc.description.sponsorshipYuzuncu Yil University Scientific Research Projects Unit [TYL-2021-9390]en_US
dc.description.sponsorshipThis study was funded by Van Yuzuncu Yil University Scientific Research Projects Unit with grant number: TYL-2021-9390.en_US
dc.identifier.doi10.31925/farmacia.2023.2.6
dc.identifier.endpage279en_US
dc.identifier.issn0014-8237
dc.identifier.issn2065-0019
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-85160059958en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage271en_US
dc.identifier.urihttps://doi.org/10.31925/farmacia.2023.2.6
dc.identifier.urihttps://hdl.handle.net/20.500.12684/13848
dc.identifier.volume71en_US
dc.identifier.wosWOS:000982169600004en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherSoc Stiinte Farmaceutice Romaniaen_US
dc.relation.ispartofFarmaciaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectaconitic aciden_US
dc.subjectendometriosisen_US
dc.subjectvitamin Cen_US
dc.subjectvitamin Een_US
dc.subjectwheatgrassen_US
dc.subjectGene-Expressionen_US
dc.subjectPeritoneal-Fluiden_US
dc.subjectOxidative Stressen_US
dc.subjectVitamin-Cen_US
dc.subjectWomenen_US
dc.subjectGrowthen_US
dc.titleExploring of the ameliorative effects of ethanolic extract of the wheatgrass (Triticumaestivum l.) On surgically induced endometriosis rat modelen_US
dc.typeArticleen_US

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