Hastane Çalışanlarında SARS-CoV-2 IgG Seropozitifliğinin Araştırılması
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Tarih
2021
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info:eu-repo/semantics/openAccess
Özet
Amaç: Şiddetli akut solunum sendromu koronavirüs 2'nin (SARS-CoV-2) neden olduğu ve devam eden edenkoronavirüs hastalığı (COVID-19) salgını, sağlık çalışanları için büyük zorluklar oluşturmaktadır. Sağlık çalışanları,hastalardan veya diğer sağlık çalışanlarından SARS-CoV-2 enfeksiyonu bulaşı açısından yüksek riskli birpopülasyondur. Bu çalışmada, Düzce ilindeki sağlık çalışanlarının cinsiyet, yaş grubu, meslek grubu, çalıştığı birim,bildirdiği semptomlar ve aile içi temas öyküsü durumu göz önüne alınarak SARS-CoV-2'ye karşı IgG yapısındakiantikor oluşturma oranlarının belirlenmesi amaçlandı.Gereç ve Yöntemler: Çalışma grubu, Düzce ilindeki pandemi birimlerinde aktif olarak görev yapan sağlıkçalışanlarından randomize olarak oluşturuldu. Katılımcılara sosyodemografik bilgilerin sorgulandığı bir anket uygulandıve kan örnekleri alındı. Antikor düzeyleri SARS-CoV-2 IgG (Euroimmun, Almanya) kiti kullanılarak mikro ELİSAyöntemi ile mikrobiyoloji laboratuvarında çalışıldı.Bulgular: Çalışmaya dahil edilen 93 sağlık personelinden 25’inde (%27) SARS-CoV-2 IgG pozitifliği saptandı. SARSCoV-2 IgG antikoru pozitif olanların 18’i (%72) asemptomatik olarak COVID-19’u geçirmişti. SARS CoV-2 IgGantikoru pozitif olanların 17’sinde ise (%68) COVID-19 pozitif kişi ile aile içi temas öyküsü yoktu. Semptomatikgeçirenlerde antikor düzeylerinin median değeri 2,90 olarak saptanmışken, asemptomatik geçirenlerde bu değer 1,31olarak bulundu.Sonuç: Sonuç olarak çalışmaya dahil edilen ve antikor pozitifliği olan sağlık çalışanlarının büyük çoğunluğununasemptomatik olarak enfeksiyonu geçirdiği ve bu kişilerdeki antikor düzeylerinin semptomatik olanlardan daha düşükolduğu görülmüştür.
Aim: The continuing outbreak of coronavirus disease (COVID-19) caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) poses enormous challenges for health care workers. Health care workers are a high-risk population for transmission of SARS-CoV-2 infection from patients or other healthcare workers. In this research, it was aimed to determine the rate of IgG antibody formation against SARS-CoV-2 by taking into account the gender, age group, occupational group, unit of work, reported symptoms and family contact history of healthcare workers in Düzce. Material and Methods: The study group was randomly formed from healthcare professionals working actively in the pandemic units in Düzce. A questionnaire questioning sociodemographic information was applied to the participants and blood samples were taken.Antibody levels were studied with the microELISA method using the SARS-CoV-2 IgG (Euroimmun, Germany) kit in microbiology laboratory. Results: SARS-CoV-2 IgG positivity was found in 25 (27%) of the 93 healthcare workers included in the study. 18 (72%) of those who were positive for SARS CoV-2 IgG antibody had passed COVID-19 asymptomatically. 17 (68%) of those who were positive for SARS CoV-2 IgG antibody did not have a family history of contact with a person positive for COVID-19.While the median value of antibody levels was 2.90 in symptomatic patients, this value was found as 1.31 in asymptomatic patients. Conclusion: As a result, it was observed that the majority of those who were included in the study and had antibody positivity had the infection asymptomatically and the antibody levels in these individuals were lower than those who were symptomatic.
Aim: The continuing outbreak of coronavirus disease (COVID-19) caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) poses enormous challenges for health care workers. Health care workers are a high-risk population for transmission of SARS-CoV-2 infection from patients or other healthcare workers. In this research, it was aimed to determine the rate of IgG antibody formation against SARS-CoV-2 by taking into account the gender, age group, occupational group, unit of work, reported symptoms and family contact history of healthcare workers in Düzce. Material and Methods: The study group was randomly formed from healthcare professionals working actively in the pandemic units in Düzce. A questionnaire questioning sociodemographic information was applied to the participants and blood samples were taken.Antibody levels were studied with the microELISA method using the SARS-CoV-2 IgG (Euroimmun, Germany) kit in microbiology laboratory. Results: SARS-CoV-2 IgG positivity was found in 25 (27%) of the 93 healthcare workers included in the study. 18 (72%) of those who were positive for SARS CoV-2 IgG antibody had passed COVID-19 asymptomatically. 17 (68%) of those who were positive for SARS CoV-2 IgG antibody did not have a family history of contact with a person positive for COVID-19.While the median value of antibody levels was 2.90 in symptomatic patients, this value was found as 1.31 in asymptomatic patients. Conclusion: As a result, it was observed that the majority of those who were included in the study and had antibody positivity had the infection asymptomatically and the antibody levels in these individuals were lower than those who were symptomatic.
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Düzce Üniversitesi Sağlık Bilimleri Enstitüsü Dergisi
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11
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3
