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Öğe Asymmetric tremor due to possible valproic acid-aripiprazole interaction in a child with severe intellectual disability(2021) Sarıgedik, Enes; Kara, Neslihan; Yektaş, Çiğdemntellectual disability is a common neurodevelopmental disorder. Antipsychotic drugs, mood stabilizers drugs are often used in this group for behavioral problems. Tremor as a symptom can develop due to the use of both valproic acid and aripiprazole which is usually manifested as symmetrical.When valproate and ari-piprazole are administered together, there may be some change in plasma concentrations of aripiprazole and its metabolite but this change is thought to be related to the displacement in plasma proteins thus effect of both drugs on changes to steady state levels is very small and not clinically significant We report the case of a 15-year-old girl is that asymmetric tremor, which occurs after valproic acid is added to treatment while using aripiprazole, and the disappearance of asymmetric tremor after reducing the dose of aripiprazole.Öğe Attention Deficit Hyperactivity Disorder Comorbidity in an Adolescent Diagnosed with L-2 Hydroxyglutaric Aciduria and Response to Atomoxetine Treatment: a Case Report(Yerkure Tanitim & Yayincilik Hizmetleri A S, 2016) Yektaş, Çiğdem; Tufan, Ali EvrenL-2-hydroxyglutaric aciduria (L-2 HGA) is a rare, neurodegenerative, slowly progressing and autosomal recessively inherited metabolic disorder. The disease progresses with mental retardation, behavioral disorder, ataxia, extrapyramidal signs and epileptic seizures. Diagnosis is made by detection of increased levels of L-2-hydroxyglutaric acid in urine, plasma or cerebrospinal fluid. In this report, we presented a 13 year old male patient diagnosed with L-2 HGA and had seizures, intellectual disability, attention deficit hyperactivity disorder (ADHD) symptoms and failure in school performance. Here we discussed this rare disease with ADHD symptoms and the response to atomoxetine treatment.Öğe Attention Deficit Hyperactivity DisorderComorbidity in anAdolescent Diagnosed withL-2 Hydroxyglutaric Aciduriaand Response toAtomoxetine Treatment:a Case Report(2016) Yektaş, Çiğdem; Tufan, Ali EvrenL-2-hidroksi glutarik asidüri tanılı bir ergende dikkat eksikliği hiperaktivite bozukluğu eş tanısı ve atomoksetin tedavisine yanıt: Bir olgu sunumuL-2-hidroksi glutarik asidüri (L-2 HGA) nadir görülen, yavaş ilerleyen ve otozomal resesifkalıtılan nörodejeneratif metabolik bir hastalıktır. Hastalık mental retardasyon, davranış bozukluğu, ataksi, ekstrapiramidal bulgular ve epileptik nöbetlerle seyreder. Tanı; idrar, plazma ya da serebrospinal sıvıda L-2hidroksiglutarik asid yüksekliği ile konulur. Bu yazıda nöbetler, mental retardasyon, dikkat eksikliği hiperaktivite bozukluğu (DEHB) belirtileri, okul başarısında sorunlarla belirti veren ve L-2 HGA tanısı konulan 13 yaşında bir erkek hastadan bahsedilmiş olup nadir görülen bu hastalığa eşlik eden DEHB semptomlarına atomoksetin tedavi yanıtı tartışılmıştır.Öğe Autistic feature and 2D: 4D finger ratio relations children and adolescents with congenital adrenal hyperplasia(Cumhuriyet Univ Tip Fak Psikiyatri Anabilim Dali, 2017) Kocaman, Gizem Melissa; Özmerdivenli, Recep; Yektaş, Çiğdem; Bolu, Semih; Haskılıç, Yunus Emre; Erdoğan, AytenObjective: Because congenital adrenal hiperplazi (CAH) and autism spectrum sisorders (ASD) is rarely seen, it is difficult to assess whether the increased incidence of ASD in girls with CAH. ASD behaviors and 2D: 4D finger ratio changes in patients with androgen overproduction have been reported. The aim of this study is determining the 2D: 4D finger ratios and ASD features in girls with CAH and normal control group. Methods: The study group will consist of thirty female children and adolescents between the ages of 3 and 15 who are diagnosed with classic CAH who were followed at the Pediatric Endocrinology Department of Duzce University Medical Faculty Hospital. For the control group, 30 healthy children and adolescents equalized with CAH patients in terms of age and gender will be taken. Al patients and controls examined for psychiatric disorders. by clinicians Patients and control groups filled Autism Behavior Checlist and semistructured sociodemogrphic form that evaluated the gender, age, pregnancy and birth complications, history of mothers' cigarette and alcohol use. 2D: 4D ratios were measured in both of control and CAH groups. Results: KAH group right and left hand 2D: 4D ratios were statistically lower compared to controls and also lower 2D: 4D ratios had association with high ABC scores. When compared with control group, CAH group ABC scores were significantly higher. In KAH group there was a pozitive correlation between 2D: 4D ratios and ABC scores. Conclusion: In light of present study findings, suggest that high androjen may have effect on low 2D: 4D ratios and high ASD symptoms. Further researchs with a large sample are needed in this field.Öğe Autistic Feature and 2D: 4D Finger Ratio Relations Children and Adolescents with Congenital Adrenal Hyperplasia [conferenceObject](Wiley-Blackwell, 2016) Kocaman, Gizem Melissa; Özmerdivenli, Recep; Yektaş, Çiğdem; Arslanoğlu, İlknur; Özdemir, Esra; Bolu, Semih; Erdoğan, Ayten…Öğe Autistic feature and 2D:4D finger ratio relations children and adolescents with congenital adrenal hyperplasia(Cukurova University, Faculty of Medicine, 2017) Kocaman, Gizem Melissa; Özmerdivenli, Recep; Yektaş, Çiğdem; Bolu, Semih; Haskılıç, Yunus Emre; Erdoğan, AytenObjective: Because congenital adrenal hiperplazi (CAH) and autism spectrum sisorders (ASD) is rarely seen, it is difficult to assess whether the increased incidence of ASD in girls with CAH. ASD behaviors and 2D:4D finger ratio changes in patients with androgen overproduction have been reported. The aim of this study is determining the 2D:4D finger ratios and ASD features in girls with CAH and normal control group. Methods: The study group will consist of thirty female children and adolescents between the ages of 3 and 15 who are diagnosed with classic CAH who were followed at the Pediatric Endocrinology Department of Düzce University Medical Faculty Hospital. For the control group, 30 healthy children and adolescents equalized with CAH patients in terms of age and gender will be taken. Al patients and controls examined for psychiatric disorders. by clinicians Patients and control groups filled Autism Behavior Checlist and semistructured sociodemogrphic form that evaluated the gender, age, pregnancy and birth complications, history of mothers’ cigarette and alcohol use. 2D:4D ratios were measured in both of control and CAH groups. Results: KAH group right and left hand 2D:4D ratios were statistically lower compared to controls and also lower 2D:4D ratios had association with high ABC scores. When compared with control group, CAH group ABC scores were significantly higher. In KAH group there was a pozitive correlation between 2D:4D ratios and ABC scores. Conclusion: In light of present study findings, suggest that high androjen may have effect on low 2D:4D ratios and high ASD symptoms. Further researchs with a large sample are needed in this field. © 2017, Cukurova University, Faculty of Medicine. All rights reserved.Öğe Bir Üniversite Hastanesi Çocuk Ergen Ruh Sağlığı ve Hastalıkları Birimi’ne Başvuran Hastaların Sağlık Kurulu Raporlarının Değerlendirilmesi(Duzce Univ, 2017) Yektaş, Çiğdem; Kaplan, Sümeyra ElifAim: In this study, we aimed to investigate sociodemographic and clinical characteristics of children and adolescents applied to a university of child and adolescent psychiatry unit and referred to the Disability Health Committee. This study results were also aimed to contribute to the previous studies about child and adolescent psychiatry disabilities. Methods: 352 children and adolescents applied to Duzce University Department of Child and Adolescent Psychiatry and referred to University Disability Health Committee between December 2016-2017 were analyzed retrospectively. Results: 58% (n=204) of patient group were female and 42% (n=148) were male. The mean age was 7.63 +/- 4.45. 38.1 % (134) of the cases were in the range of 0-6 years of age, 46 % (162) of the cases were in the range of 7-12 years of age and 15.6 % (55) of the cases were in the range of 13-28 years of age. The most common reasons for admission were special educational needs due to developmental delays and academic problems. (% 74,7 n=263) and health status report for homecare-payment and salary (% 25,3 n=89). The most common clinical diagnoses were mental retardation and developmental delay (% 36,1 n=127), learning disorder (% 20,2 n=71) and pervasive developmental disorders (% 11,1 n=39) respectively. Conclusion: In pediatric population early diagnoses of developmental delays, autism spectrum disorders and learning disorders and developing medical and educational strategies would help to reduce disability ratios and also enhance academic and social functionality of children.Öğe Bir Üniversite Hastanesi Çocuk Ergen Ruh Sağlığı ve Hastalıkları Birimi'ne Başvuran Hastaların Sağlık Kurulu Raporlarının Değerlendirilmesi(2017) Kaplan, Sümeyra Elif; Yektaş, ÇiğdemAmaç: Bu çalışmanın amacı bir üniversite hastanesinin çocuk ergen ruh sağlığı polikliniğinde değerlendirilerek sağlık kuruluna yönlendirilen çocuk ve ergen hastaların sosyodemografik ve klinik özelliklerini belirleyerek çocuk ruh sağlığı alanındaki engellilik ve engelli hakları konusunda yapılan önceki çalışmalara katkı sağlamaktır. Metot: 2016-2017 tarihleri arasında Düzce Üniversitesi Tıp Fakültesi Hastanesi Çocuk Ergen Ruh Sağlığı Hastalıkları Polikliniği'nde değerlendirilen ve Özürlü Sağlık Kurulu'na yönlendirilen 352 çocuk ve ergen alınmıştır. Sosyodemografik ve klinik verileri dosya bilgileri üzerinden geriye dönük olarak değerlendirilmiştir. Bulgular: Hastaların %58'si (n204) erkek %42'si (n148) kız cinsiyettedir. Hasta grubunun yaş ortalaması 7,634,45 olarak saptanmıştır. Başvuru sebepleri arasında ilk sırada gelişimsel becerilerdeki gecikme ve/veya akademik becerilerdeki geriliğe bağlı olarak özel eğitim ihtiyacı (%74,7 n263) gelmekte olup bunu bakım ücreti talebi ve özür oranının belirlenmesine yönelik durum bildirir rapor izlemiştir (%25,3 n89). Hastalarla yapılan klinik görüşme ve değerlendirmelere göre aldıkları psikiyatrik tanılar içinde zekâ geriliği (%36,1 n127), özgül öğrenme güçlüğü (%20,2 n71) ve otizm spektrum bozukluğunun (%11,1 n39) en sık psikiyatrik tanılar olduğu belirlenmiştir Sonuç: Çocukluk çağında zihinsel engellilik, otizm, öğrenme güçlüğü gibi durumların çok erken tespit edilebilmesi ve yapılacak erken eğitsel müdahaleler çocuklardaki engellilik oranını azaltabileceği gibi gerek akademik gerekse sosyal alanda yaşanabilecek işlev kayıplarını büyük oranda telafi edilebilmektedir.Öğe Cinsel istismar mağduru çocuk ve ergenlerde istismar ve istismarcıya ilişkin özelliklerin ve psikopataloji ile ilişkili risk etkenlerinin değerlendirilmesi(2018) Yektaş, Çiğdem; Tufan, Ali Evren; Büken, Bora; Çetin, Nihal Yurteri; Yazıcı, MerveAmaç: Bu çalışmada, bir çocuk ve ergen ruh sağlığı ve hastalıkları kliniğine adli mercilerce yönlendirilen istismar mağduru çocuk ve ergen olguların sosyodemografik özelliklerinin, istismar ve istismarcıların niteliğinin ve istismar sonrası klinik tanılarının değerlendirilmesi ile psikopatoloji gelişimini yordayan etkenlerin belirlenmesi amaçlan-mıştır. Yöntem: Adli mercilerce yönlendirilen 3-18 yaşları arasındaki 106 çocuk ve ergenin (83 kız, 23 erkek) sosyo-demografik ve klinik bilgileri dosyaları ve adli raporları incelenerek geriye dönük olarak değerlendirilmiştir. Bulgular: Örneklemin %63.2’si ergenlik dönemindeki kızlardan oluşuyordu. En sık bildirilen cinsel istismar tipi cinsel uyarılma için bedene dokunmaydı (%47.2). Çocukların %10.4’ünün birden fazla yolla cinsel istismara uğradığı belirlendi. Olguların %32.1’i cinsel istismar sırasında fiziksel şiddet görmüştü. Örneklemin %17.0’si başka istismar türlerine de uğramıştı. Tüm örneklemde yineleyen cinsel istismar oranı %69.8 olarak saptandı. Cinsel istismar edilen olgula-rın %50.0’ının aile içinde farklı tipte istismarlara da uğradığı bildiriliyordu. Cinsel istismara maruz kalan çocuklara en sık konulan klinik tanılar sırasıyla travma sonrası stres bozukluğu (%24.5), uyum bozukluğu (%16.0) ve akut stres bozu kluğu (%11.3) oldu. Sonuç: Çalışmamızdaki olguların önemli bir bölümünün kızlardan oluşması kız çocukların daha fazla istismara maruz kaldığı bilgisini desteklemektedir. İstismarcıların hepsi erkek cinsiyette olup çoğunlukla çocuğun tanıdığı kişilerdir. Zeka geriliği olan ve istismar sırasında fiziksel şiddet gören çocuk ve ergen-lerde ruhsal sorun gelişme riski daha yüksek bulunmuştur. (Anadolu Psikiyatri Derg 2018; 19(5):501-508)Öğe Clinical and Sociodemographic Characteristics of Institutionalized Children in Duzce(Duzce Univ, 2018) Yektaş, Çiğdem; Tufan, Ali Evren; Yazıcı, MerveObjective: In this study, it is aimed to investigate sociodemographic and clinical characteristics of children and adolescents who are under institutional care in Duzce city and the factors that may be related to mental problems. Methods: A total of 61 children and adolescents in institutional care were enrolled at the Duzce University Child and Adolescent Psychiatry Department during the period of 2016-2018 years. Clinical evaluations of the patients were made according to the DSM 5 diagnostic system and the patients were evaluated by the Depression Scale for Children, Beck Depression Scale, Scanning and Assessment Scale for Anxiety and Related Disorders, Beck Anxiety Scale, and also the Screening and Assessment Scale for Disruptive Behavioral Disorders Based on DSM-IV was filled by institutional staff and teachers. Results: The most common causes of institutional care were poverty, failure to provide basic care for the child, neglect and abuse. The median age for to be institutionalized was 96 months, and the median duration for the institution care was 36 months. At least one psychopathology was found to be diagnosed in 90.2% of 61 children. The most frequent clinical diagnoses were ADHD, MDD, DBD, MR and LD. The relationship between psychopathology presence and parental separation also between inattention, hyperactivity / impulsivity, oppositional behaviour and behavioral problems reported by both teachers and institutional officials was found to be significantly correlated. Conclusion: Our findings may suggest that even if even if the child remains in the institution, the parents' ability to continue living together may have a protective effect. On the other hand, the behavioral problems reported by the institutional staff and the attention problems that teachers observe may be stimulating for different psychopathologies in these children.Öğe Comparison of serum B12, folate and homocysteine concentrations in children with autism spectrum disorder or attention deficit hyperactivity disorder and healthy controls(Dove Medical Press Ltd, 2019) Yektaş, Çiğdem; Alpay, Merve; Tufan, Ali EvrenObjective: We aimed to investigate the serum concentrations of vitamin B12, folate and homocysteine in children diagnosed with attention deficit hyperactivity disorder (ADHD) or autism spectrum disorder (ASD) and healthy controls. Materials and methods: Serum vitamin B12, folate and homocysteine concentrations were measured in 118 children (48 children diagnosed with ADHD, 35 children diagnosed with ASD and 35 healthy controls). Symptom severity in the ADHD and ASD groups was evaluated by the Childhood Autism Rating Scale and Turgay-DSM-1V-Based Screening and Assessment Scale for Disruptive Behavior Disorders. Multivariate analysis of covariance was used to evaluate the effects of diagnosis and gender on biochemical parameters. Results: The ADHD and ASD groups and the healthy controls differed significantly regarding vitamin B12 and homocysteine concentrations, but not folate levels. Patients with ASD had the lowest vitamin B12 and the highest homocysteine levels. Vitamin B12 levels correlated negatively with hyperactivity and/orimpulsivity and oppositionality symptoms in children with ADHD. There were no relationships between psychometric evaluations and laboratory measurements in children with ASD. Gender did not affect vitamin concentrations. Conclusion: Previous studies found that vitamin B12 was reduced while homocysteine was elevated among patients with ADHD and ASDs. Our results also support those reported previously. Oppositionality and hyperactivity and/orimpulsivity may be related to vitamin B12 and homocysteine levels in children with ADHD. Further studies are required to define the role of these parameters and effects on the etiology and clinical manifestations of ASD and ADHD.Öğe Evaluation of abuse and abuser's features and risk factors associated with psychopathology in children and adolescents victimized by sexual abuse(Cumhuriyet Univ Tip Fak Psikiyatri Anabilim Dali, 2018) Yektaş, Çiğdem; Tufan, Ali Evren; Büken, Bora; Yurteri Çetin, Nihal; Yazıcı, MerveObjective: The aim of this study to determine sociodemographic variables, characteristics of abuses and abusers, clinical diagnosis after abuse and factors associated with the psychopathology of sexually abused children and adolescents who referred to the department of child and adolescent psychiatry with the request of criminal report. Methods: Sexually abused 106 children and adolescents (83 girls and 23 boys) aged 3-18 years who referred for criminal reports were evaluated. Case files and criminal reports were examined retrospectively. Results: Great majority of the group was consisted of adolescent girls (63.2%). Touching to the body for sexual arousal was the most reported type of the sexual abuse (47.2%). 10.4% of the children reported multiway abuse. 32.1% of the cases experienced physical violence during sexual abuse. Other victims were also present in 17.0% (n=18) Recurrent sexual abuse was found in 69.8% of cases. 50.0% of sexually abused cases were also exposed to different types of abuse within the family. The most common clinical diagnoses were post-traumatic stress disorder (24.5%) adjustment disorder (16.0%) and acute stress disorder (11.3%). Conclusion: Consistent with the literature, our finding, in which a significant proporiton of the cases were girls, shows that the girls are exposed to the sexual abuse more than boys. All abusers are male who were mostly familiar to the victims. Children and adolescents with mental retardation and experienced physical violence during abuse had a higher risk of developing psychopathology.Öğe Evaluation of Sociodemographic and Clinical Profiles of Adolescents Under-18 Years of Age Referred by the Judicial Authorities for Marriage License(2019) Yektaş, Çiğdem; Büken, BoraObjective: The aim of this study was to investigate the sociodemographic and clinical characteristics of adolescents referred to a university hospital by the judicial authority for determining whether any mental and physical impediments to marriage exist. Methods: 70 adolescents who were consulted to child and adolescent psychiatry inquired by the judicial authorities if there was any impediment to marriage were included to study. Psychiatric examination of the adolescents was performed according to DSM 5. Data obtained from the study were examined retrospectively with the method of file scanning system. Results: Mostly (94.3%) female children with a mean age of 16.05 ± 0.2 years were included in the study. None of the children attended to school during the assessment. Most (89.5%) of the children were living in a family environment with a low socioeconomic level. The most frequently psychiatric diagnoses were; attentiondeficit hyperactivity disorder (%4.3, n=3), depressive disorder (%4.3, n=3), mental retardation (%2.8, n=2) and post-traumatic stress disorder (%1.4, n=1). 85.7% of the children decided to marry individuals they got acquainted from their immediate circle or from social media, while marriage of only 14.3% (n=10) of them were previously arranged by their families. Conclusions: Socio-economic level, family characteristics and attending to school are important predisposing factors for early marriages. It was also considered that marriage at this age means an attempt for gaining an early autonomy. Encouraging to continue formal education for the development of healthy autonomy will be an important factor to prevent early marriages.Öğe Factors affecting disclosure time of sexual abuse in children and adolescents(Wiley, 2022) Yurteri, Nihal; Erdogan, Ayten; Büken, Bora; Yektaş, Çiğdem; Çelik, Mehmet SakiBackground The aim of this study is to determine the factors affecting early and delayed disclosure time of child sexual abuse (CSA). Early disclosure of CSA is considered to be crucial for child protection. Methods A total of 125 sexually abused children and adolescents, who had been evaluated by child adolescent psychiatry and forensic medicine specialists, were enrolled in this study. Files of medical and criminal data were analyzed retrospectively and synchronously by child adolescent psychiatrist and forensic medicine specialist authors who had evaluated victims using the standard procedures of Duzce University Faculty of Medicine Child Abuse Assessment Council. Univariate and multivariate logistic regression analyses were conducted to evaluate predictors. Results Delayed disclosers were found to be younger than early disclosers. Among the delayed disclosers, there were also more victims of intrafamilial CSA, fewer victims of penetration, and fewer voluntary disclosures. Multivariate logistic regression revealed that younger age and intrafamilial CSA were independent predictors of delayed disclosure of CSA. Conclusions The results of our study contribute to an understanding of the factors related to delayed disclosure and underline the need for age-appropriate education and prevention programs targeted to increase the awareness of sexual abuse, particularly intrafamilial abuse, and to promote voluntary disclosure in children and adolescents, especially for younger age groups. The education of potential recipients of CSA and further education of professionals is extremely important in order to support children and adolescents' voluntary disclosure of CSA.Öğe Hyperactive delirium and its symptomatic treatment with risperidone in a paediatric patient: a case report(Taylor & Francis Ltd, 2019) Küçükdağ, Meltem; Yektaş, ÇiğdemDelirium is a rapid-onset disorder with a fluctuating course and a wide range of underlying causes. It is commonly characterized by altered mental status, disturbance of consciousness and cognition, as well as disruptions in the sleep-wake cycle. Although delirium is a relatively complicated condition due to the variability of aetiological risk factors, clinical manifestations, and progress; it is generally reversible. An accurate identification of underlying causes and risk factors is therefore essential for early-stage diagnosis and positive treatment outcomes in delirium cases. Paediatric delirium can be due to various aetiologies and its clinical signs can differ from those of adults. Because of the increased prevalence of missed cases of delirium in paediatric population and relative scarcity of the publications based on Turkish cases, this case presentation can be deemed important. We present a 16-year-old boy diagnosed with Hodgkin's lymphoma who has recurrent hyperactive delirium symptoms such as disorientation, irritability, psychomotor agitation, and visual hallucinations during his chemotherapy sessions and respond to low-dose risperidone treatment.Öğe Imipramine-induced mania in a child diagnosed with attention-deficit/hyperactivity disorder (ADHD): a case report(Taylor & Francis Ltd, 2018) Yektaş, Çiğdem; Tufan, Ali EvrenChildren and adolescents treated with antidepressants (ADs) are at higher risk for developing hypomania and mania compared with adults. It was suggested that AD-induced mania represent a predisposition to bipolar disorder (BD) so it may accelerate the course of BD in this risky population. According to the literature, susceptibility to manic conversion with the use of ADs is higher in BD patients treated with tricyclic ADs compared with selective serotonin reuptake inhibitors (SSRIs) and placebo. Here, we report a six-year-old girl who was diagnosed with attention-deficit/hyperactivity disorder (ADHD) and primary nocturnal enuresis who developed manic symptoms after imipramine treatment. While using tricyclic antidepressants or SSRIs for different indications in the paediatric population, clinicians should be alert for the manic switch or behavioural activation symptoms, which may show a bipolar predisposition.Öğe Increased Frequency of Encopresis in a Child Diagnosed With Attention Deficit/Hyperactivity Disorder and Encopresis After Atomoxetine Use: A Case Report(Lippincott Williams & Wilkins, 2016) Yektaş, Çiğdem; Cansız, Mehmet Akif; Tufan, Ali EvrenAttention deficit hyperactivity disorder (ADHD) is among the most frequently reported coexisting psychiatric conditions in children with encopresis. Some case reports state that atomoxetine-a selective presynaptic norepinephrine reuptake inhibitor-approved for treatment of ADHD is also effective in the treatment of coexisting encopresis. Contrasting those reports, here we present a case diagnosed with ADHD and secondary encopresis without constipation whose encopretic symptoms increased after atomoxetine treatment and discuss possible mechanisms.Öğe Increased Trichotillomania Symptoms in a Child With Fluoxetine Treatment(Lippincott Williams & Wilkins, 2017) Yektaş, Çiğdem; Tufan, Ali EvrenTrichotillomania (TTM) is a mental disorder characterized by uncontrolled and impulsive hair pulling leading to hair loss, distress, and disordered functioning. Treatment choices include behavioral therapy (especially habit reversal training) and selective serotonin reuptake inhibitors. However, randomized controlled trials conducted with selective serotonin reuptake inhibitors have led to controversial results of effectiveness for TTM. Here, we report a female patient whose TTM symptoms increased after fluoxetine use.Öğe Konjenital adrenal hiperplazisi olan çocuk ve ergenlerde otistik özellikler ve 2D:4D parmak oranlarının ilişkisi(2017) Kocaman, Gizem Melissa; Özmerdivenli, Recep; Yektaş, Çiğdem; Bolu, Semih; Haskılıç, Yunus Emre; Erdoğan, AytenAmaç: Hem konjenital adrenal hiperplazi (KAH), hem de otizm spektrum bozukluğu (OSB) çok nadir olarak görüldüğünden, KAH olan çocuk ve ergenlerde OSB görülme oranının artmış olup olmadığını saptamak güçtür. KAH ile OSB'nin düşük 2D:4D parmak oranları arasında ilişki olabileceği bildirilmiştir. Bu çalışmada KAH olan çocuk ve ergenlerde ve normal kontrol grubu çocuklarda OSB ve 2D:4D parmak oranları arasındaki ilişkinin belirlenmesi amaçlandı. Yöntem: Çalışmaya, 3-18 yaşları arasında, Düzce Üniversitesi ve Erciyes Üniversitesi Tıp Fakültesi Hastanesi Çocuk Endokrinolojisi bölümünde izlenen klasik KAH tanısı konmuş otuz çocuk ve ergen alındı. Kontrol grubuna yaş ve cinsiyet açısından hasta grubuyla bire bir eşleştirilmiş 30 sağlıklı çocuk ve ergen alınmıştır. Araştırma kapsamındaki çocuk ve ergenlerin anne-babalarının Otizm Davranış Kontrol Listesi (Autism Behavior Checklist-ABC) ve sosyodemografik veri formunu doldurmaları sağlandı. Sosyodemografik veri formunda olgunun yaş, cinsiyet, annenin gebeliği sırasında yaşadığı psikiyatrik ve fiziksel sorunlar, sigara, alkol kullanım öyküleri, aldığı ilaç ve tedaviler, gebelik komplikasyonları, erken ve zor doğum öyküsü sorgulandı. Çalışmaya alınan tüm olgularla psikiyatrik eş tanıları dışlamak amacıyla klinik görüşme yapıldı. Bulgular: KAH ve kontrol grubunun sağ ve sol el 2D:4D oranları karşılaştırıldığında, KAH'lı grupta sağ el 2D:4D oranı istatistiksel olarak anlamlı düzeyde düşük saptandı. KAH grubu, kontrol grubu ile karşılaştırıldığında, KAH grubu ABC ölçeği puanları istatistiksel olarak anlamlı düzeyde yüksek bulundu. KAH'li grupta ABC ölçeği puanları ile sağ el 2D:4D oranları arasında pozitif korelasyon saptandı. Sonuç: Çalışmamızda elde edilen sonuçlara göre, düşük sağ el 2D:4D oranı ile OSB'nin etiyolojisinde testosteron hormonunun rolünün olabileceği şeklinde yorumlanabilir. Gelecekte sadece her iki cinsiyetteki çocuk ve ergenlerin alt tip dağılımındaki sayıları artırılarak yapılacak çalışmaların bu ilişkilerin daha iyi tanımlanabilmesi açısından önemli olabileceğini düşünmekteyiz.Öğe Loss of Eyebrows (Madarosis) After Use of Long-Acting Methylphenidate: Case Report(Lippincott Williams & Wilkins, 2017) Yektaş, Çiğdem; Samurcu, Nuran Demir; Tufan, Ali Evren…
