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Öğe Association of anxiety, sleepiness, and sexual dysfunction with restless legs syndrome in hemodialysis patients(Wiley-Blackwell, 2014) Dikici, Süber; Bahadır, Anzel; Baltacı, Davut; Ankaralı, Handan; Eroğlu, Mustafa; Ercan, Nurten; Sav, TansuRestless legs syndrome (RLS) is characterized by unpleasant sensations, pain in the legs along with irresistible urges to move the legs when at rest. It is often accompanied by sleep disturbance. The purpose of this study was to assess the association of anxiety and sleepiness with sexual function in hemodialysis patients with and without RLS. Sociodemographic parameters, laboratory data of hemodialysis patients from three dialysis centers were collected prospectively. Anxiety, sleepiness, sexual function, and presence of RLS symptoms were assessed with standardized questionnaires as the RLS Diagnosis and Scale, Hamilton Anxiety Rating Scale, Epworth Sleepiness Scale (ESS), Arizona Sex Experiences Scale (ASEX). Univariate, regression tree method were used for statistical analysis. RLS was observed in 45.9% (n=113) of hemodialysis patients (n=246). The mean age of patients and duration of hemodialysis were 59.7 +/- 14.0 and 4.9 +/- 4.2 years, respectively. The correlation between Arizona Sexual Experiences Scale (ASEX) and sociodemographic features was significant (P<0.0001). Patients with RLS had higher scores for anxiety (9.4 +/- 7.8 with RLS and 6.8 +/- 6.0 without), higher ESS (ESS, 6.6 +/- 5.2 with RLS and 4.6 +/- 4.0 without), and higher ASEX (24.6 +/- 5.7 with RLS and 22.5 +/- 6.8 without) than did those without RLS. The presence of RLS symptoms in hemodialysis patients was associated with sleepiness, anxiety, and sexual dysfunction. A regression tree method, which is a different statistical method, can help physicians estimate patients ASEX, RLS, ESS, and anxiety scores.Öğe Can influenza H1N1 vaccination lead to the membranous glomerulonephritis?(Medknow Publications, 2012) Kutlucan, Ali; Gönen, İbak; Yıldızhan, Esra; Aydın, Yusuf; Sav, Tansu; Yıldırım, ÜmranIn 2009 winter, Influenza A (H1N1) monovalent split virus vaccine was used prevalently in the whole world as a result of the pandemic caused by Influenza (H1N1) virus. The vaccine's adverse effects were observed closely and vaccination has been found as safe in most studies. But some reports about immune response related diseases after influenza vaccinations are remarkable. The close relationship between membranous glomerulonephritis and antigens is known, particularly in seconder forms which occur after viral infections and vaccinations. So this case report is about a 56-year-old man, who developed membranous glomerulonephritis 23 days after the vaccination against Influenza A (H1N1) virus.Öğe The effects of ultrafiltration and diuretic therapies on oxidative stress markers in patients with cardio-renal syndrome(Edizioni Minerva Medica, 2017) Sav, Tansu; Çeçen, Faruk; Albayrak, Enver SinanBACKGROUND: Cardiorenal syndrome (CRS) is defined as complex pathophysiological disorder of the heart and kidneys. Both heart and renal failure are characterized by increased systemic oxidative stress in CRS. The aim of the present study is to assess the impacts of ultrafiltration (UF) and furosemide treatment on oxidative stress markers and renal functions in patients with CRS. METHODS: In the study 77 patients with CRS (37 patients in the UF group and 40 patients in the furosemide group) were included. Plasma superoxide dismutase (SOD), catalase (CAT), malondialdehyde (MDA), glutathione peroxidase (GSH-Px) levels were studied in all patients on admission and at the end of the study. RESULTS: Plasma SOD, CAT, MDA and GSH-Px levels did not show significant difference between the groups. CONCLUSIONS: The effects of UF and furosemide therapies were similar on oxidative stress markers in patients with CRS. These methods safely decrease volume overload in a short-term period.Öğe An evaluation of suspected cases of Hantavirus infection admitted to a tertiary care university hospital in Duzce, Turkey, between 2012 and 2018(Tubitak Scientific & Technical Research Council Turkey, 2021) Ince, Nevin; Onec, Kursad; Sav, Tansu; Sungur, Mehmet Ali; Menemenlioglu, DilekBackground/aim: Hantavirus is a rodent borne zoonosis caused by the members of the virus family Bunyaviridae, genus Hantavirus. In this study, we aimed to determine the role of peripheral blood leukocyte ratio in differential diagnosis of Hantavirus disease. Materials and methods: The medical records of patients at the Duzce University Medical Faculty were examined retrospectively. A total of 20 patients diagnosed with hantavirus infection confirmed by serologic tests were included in the study (Group 1). The other group consisted of 30 patients suspected of hantavirus infection but found negative (Group 2). Demographic, clinical and laboratory characteristics, neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR), and lymphocyte/monocyte (LMR) ratios of both groups were compared. Results: As a result of the istatistics analysis, no difference was found between the groups' age, sex, and clinical complaints except lethargy-weakness (P = 0.004) and diarrhea (P < 0.001). Hemogram analysis showed a significant difference between the groups in terms of leukocyte, hemoglobin, hematocrit, platelet, mean platelet volume (P < 0.05) and PLR (P = 0.001) and LMR (P = 0.003) values from peripheral blood leukocyte ratios. Conclusion: In conclusion, NLR, PLR, and LMR ratios may be useful for clinicians in differential diagnosis of Hantavirus in patients presenting with similar symptoms of Hantavirus disease.Öğe Hemodialysis-related headache(Wiley, 2014) Sav, Murat Yusuf; Sav, Tansu; Şenocak, Elif; Sav, Nadide MelikeHeadache is one of the most frequently encountered neurological symptoms during hemodialysis. According to International Classification of Headache criteria dialysis-related headache was defined as the headache occurring during hemodialysis with no specific characteristic. It resolves spontaneously within 72 hours after the hemodialysis session ends. There are few studies in the literature investigating the clinical features of dialysis headache. The pathophysiology of hemodialysis-related headache is not known, but various triggering factors have been identified, including changes in blood pressure, serum sodium and magnesium levels during hemodialysis sessions, caffeine deprivation and stress. The aim of this article is to evaluate and analyze features of headache in patients undergoing hemodialysis.
