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A Case with Diffuse Granulomatous Inflammation Mimicking Malignancy
(Düzce Üniversitesi, 2017) Erçelik, Merve; Balbay, Ege Güleç; Arbak, Peri; Ataoğlu, Özlem
A 59-year-old female patient was admitted to outpatient clinic with a 3-week dry cough and a 2-month exercise dyspnea (MRC 2). Within the last 3 months there was a loss of 5 kg. She has never smoked. She was a housewife. In thoracic computed tomography of the patient’s postero-anterior chest x-ray, the right lower quadrant is the opacity of the right atrium. A large number of nodules (5 mm in size) in both upper lobes of the lungs, and a common reticulonodular dancer in the middle lobe of the right lingula. The desired positron emission tomography of the patient with malignancy pre-diagnosis; right lobe of the lungs, reticular densities in the left lung, gastroesophageal junction, stomach fundus and large curvature in the dorsal wall of the nasopharynx, bilateral cervical lymphadenopathies, bilateral cervical lymphadenopathies, bilateral lymph nodes, right lobe of the lungs, right scapula and left iliac bone intense hypermetabolic involvement was detected. The axillary lymph node dissection was diagnosed as granulomatous lymphadenitis. The patient was accepted as sarcoidosis, inhaled steroid therapy was initiated and followed.
Are serum eosinophilic cationic protein levels of toll collectors affected by diesel exhaust exposure?
(Professional Medical Publications, 2016) Bilgin, Cahit; Arbak, Peri Meram; Yavuz, Özlem; Balbay, Ege Güleç; Balbay, Öner Abidin; Annakkaya, Ali Nihat
Objective: There are few studies on the diesel exhaust particulates (DEP) / eosinophilic cationic protein (ECP) level relationship. This study aimed to detect ECP levels in a highly DE exposed group, named as toll collectors. Methods: In a cross-sectional study, levels of serum ECP, rates of respiratory symptoms, mean levels of respiratory functions, smoking status, and variations in peak expiratory flow (PEF) during weekends and working days were compared for 68 toll collectors (TC) (range of age, 24-48 years) and 28 controls (range of age, 25-61 years). All subjects in the study group were men. Results: No significant difference was observed in terms of symptoms and smoking rates between the toll collectors and control group. The number of toll collectors [12/68 (17.7%) vs 1/28 (3.5%)] with diurnal PEF variability in the working period was higher than that of controls (p=0.058). Mean ECP level of toll collectors was higher than that of controls (32.8 vs 21.4 ng/L), but the difference was not significant. Mean ECP levels were higher in subjects experiencing diurnal PEF variability during work and off-work periods (34.9 vs 28.3 ng/L, p=0.410). Conclusions: Serial PEF measurements combined with serum ECP measurements did not add a new tool to detect the sensitivity of workers dealing with DE. Much more diesel exhaust exposed workers should be included to search for cheap and available methods when evaluating airway.
An assessment of post-COVID-19 infection pulmonary functions in healthcare professionals
(Mosby-Elsevier, 2022) Gülhan, Pınar Y.; Arbak, Peri M.; Annakkaya, Ali N.; Balbay, Ege Güleç; Balbay, Öner A.
Background: The medium- and long-term effects of COVID-19 infection on pulmonary function are still unknown. The present study aimed to investigate the pulmonary functions in healthcare professionals who had persistent complaints after contracting COVID-19 and returning to work. Methods: The study included COVID-19-infected healthcare professionals from the Dueurozce University Medical Faculty Hospital who volunteered to participate. Medical histories, medical records, pulmonary function tests, the diffusing capacity of the lungs for carbon monoxide (DLCO) test, and the 6-minute walk test (6MWT) were used to collect data from all participants. Results: The study included 53 healthcare professionals, with an average age of 38 +/- 10 years (min: 24 years and max: 71 years), including 29 female (54.7%) and 24 male (45.3%) participants. Of the participants, 22.6% were smokers, 35.8% (19 individuals) had comorbidities, and 17% (9 individuals) were hospitalized. The mean length of stay was 9 +/- 4 days (mean +/- standard deviation). The most prevalent symptoms were weakness (88.7%), muscle aches (67.9%), inability to smell/taste (60.4%), headache (54.7%), fever (45.3%), cough (41.5%), and shortness of breath (37.7%). The mean time to return to work after a positive polymerase chain reaction (PCR) test for COVID-19 was 18 +/- 13 days. The average time among post-disease pulmonary function, 6MW, and DLCO tests was 89 +/- 36 days (min: 15 and max: 205). The DLCO level decreased in 39.6% (21) of the participants. Female participants had a significantly higher rate of decreased DLCO levels than male participants (25% vs. 55.2%, P = .026). DLCO levels were significantly higher in participants with longterm persistent complaints (P = .043). The later the time to return to work, the lower the DLCO value (r=-0.290 and P = .035). The 6MWT distance was positively correlated with hemoglobin and lymphocyte levels at the time of the disease onset and negatively correlated with D-dimer levels. The most prevalent symptoms during the control visits were shortness of breath/effort dyspnea (24.6%), weakness (9.5%), and muscle aches (7.6%). Conclusion: Significant persistent complaints (47.2%) and low DLCO levels (39.6%) were observed in healthcare professionals during control visits at a mean time of 3 months after the COVID-19 infection. Symptoms and spirometry measurements, including DLCO, may be helpful in the follow-up of healthcare professionals who contracted COVID-19. Further comprehensive studies with long-term follow-up periods are required. (c) 2022 Association for Professionals in Infection Control and Epidemiology, Inc. Published by Elsevier Inc. All rights reserved.
ASTIM TANILI HASTALARDA GELENEKSEL VE TAMAMLAYICI TIP YÖNTEMİ KULLANIMLARININ DEĞERLENDİRİLMESİ Evaluation of Traditional and Complementary Medicine Methods in Asthmatic Patients
(Yozgat Bozok University, 2020) Gülhan, Pınar Yıldız; Üzer, Fatih; Balbay, Ege Güleç
ÖZET Giriş: Günümüzde kronik hastalıkların artmasına paralel olarak, hastalıkların tedavisinde ve semptomların hafifletilmesinde Geleneksel ve Tamamlayıcı Tıp (GETAT) yöntemlerinin kullanımı artmaktadır. Bu çalışma astım tanılı hastaların GETAT kullanımlarını değerlendirmeyi amaçlamıştır. Gereç ve Yöntemler: Çalışmaya Kastamonu Devlet Hastanesi ve Düzce Üniversitesi Tıp Fakültesi Göğüs Hastalıkları Polikliniğine Aralık 2018-Şubat 2019 tarihleri arasında başvuran ve 6 aydan uzun süredir astım tanısı olan hastalar alındı. Yüz-yüze görüşme şeklinde yapılan ankette katılmayı kabul edenlere GETAT yöntemleri hakkındaki eğilimlerini ölçen sorular yöneltildi. Anket soruları GETAT kullanımını değerlendiren literatürler göz önüne alınarak göğüs hastalıkları bölümünde çalışan iki öğretim üyesi tarafından hazırlanmıştır. Hastaların demografik verileri ve anket cevapları değerlendirildi. Bulgular: 71 hastanın yaş ortalaması 51±16.38 (minimum=19, maksimum=78 yıl) olup vakaların %21,1’i erkek (n=15), % 78,9’u (n=56) kadındı. Hastaların %35,2’si (n=25) GETAT yöntemlerinden birini kullandığını ve bu yöntemi kullanan hastaların %75’i (n=18) yarar gördüğünü ifade etmişlerdi. Hastaların %54,2’si bitkisel, %20 ,8 ‘i apiterapi, %12,5’i hacamat, %4,2’si termal, %4,2’si tuz ve %4,2’si akupunktur yöntemini kullanmıştı. Astım kontrol düzeyi ve cinsiyet ile GETAT kullanımı arasında fark yoktu. Ek hastalığı olanlar olmayanlara göre GETAT yöntemini az kullanmaktaydı (p=0,049). Sonuç: Astım hastalarında her üç kişiden birinin GETAT yöntemini kullandığı, sıklıkla da bitkisel ürünlerin tercih edildiğini saptadık. Astım hastalarında GETAT kullanımı konusunda geniş çaplı çalışmalara gereksinim vardır. Anahtar kelimeler: Astım; Geleneksel ve tamamlayıcı tıp; Kontrol ABSTRACT Introduction: Nowadays, in parallel to increase in chronic diseases, the use of Traditional and Complementary Medicine (TCAM) methods is increasing in the relieving symptoms and treatment. This study aimed to evaluate TCAM use of asthma patients. Material and Method: Patients with asthma diagnosis more than 6 months who admitted to Kastamonu State Hospital and Duzce University Faculty of Medicine, Department of Chest Diseases between December 2018-February 2019 were included to study. Questions that measure the tendency of TCAM methods to those who accepted to participate in the face-to-face interview were asked. Survey questions were prepared by two faculty members working in the chest diseases considering the literature that was evaluating the use of TCAM. Demographic data and questionnaire responses of the patients were evaluated. Results:The mean age of 71 patients was 51±16.38 (minimum=19, maximum=78 years). 21.1% of the patients were male (n=15) and 78.9% (n=56) were female. Of the patients, 35.2% (n=25) reported using one of the TCAM methods, and 75% (n=18) of the patients were benefiting from used method. Of the patients 54.2% had used herbal, 20.8% had apitherapy, 12.5% had hijama, 4.2% had thermal, 4.2% had salt and 4.2% used acupuncture. There was no difference between asthma control level, gender and TCAM use. Patients with comorbidities, used the TCAM method less than those without (p=0.049). Conclusion: It was determined that one of three asthma patients used TCAM method and often found that herbal products are preferred. Large-scale studies about use of TCAM in asthma patients are needed. Key words: Asthma; Control; Traditional and complementary medicine
Bilgisayarlı Toraks Tomografisini gereğinden fazla mı istiyoruz?
(2015) Balbay, Ege Güleç; Safçı, Sinem; Çakıroğlu, Emine Banu; Şafak, Alp Alper
Amaç: Bu çalışmada Göğüs hastalıkları polikliniğine başvurmuş hastalardan istenen Toraks Bilgisayarlı Tomografileri (BT)nin hangi nedenlerle istendiğini ve saptanan radyolojik anormallikleri araştırmak amaçlandı. Yöntem : Tıp Fakültesi Göğüs Hastalıkları polikli niğinde 3 ay boyunca bakılmış tüm hastalardan istenmiş Toraks BTler retrospektif olarak değerlendirildi. Bulgular: 3245 hastanın 215ìnden (%6.62) Toraks BT istenmişti. Yaş ortalamaları 5814.97 olan 215 hastanın 142sı erkek (%66) idi. International Clas sification of Diseases (ICD) kodlarına bakıldığında en sık 57 (%26.5) hastada öksürük, 49 (%22,8) hastada akciğerin tanısal görüntülenmesinde anormal bulgular ve 18 (%8.4) hastada da hemoptizi tanılarıyla Toraks BT istenmişti. İstenen tomografilerin 185 (% 86)sında patoloji saptanmıştı. En sık görülen radyolojik anormallikler sırasıyla lenfadenopati 69 (%32,1), nodül 60 (%27.9), fibrotik değişiklik 49 (%22.8) idi. Bronş kanseri tanısıyla istenen Toraks BTlerin %100 ünde klinik olarak önemli en az bir pato loji saptanmışken, göğüs ağrısı tanısıyla istenenlerin ise %55.6sında klinik olarak önemli patoloji saptanmamıştı. Sonuç : Üçüncü basamak bir göğüs hastalıkları polikliniğinden istenen Toraks BTlerin çoğunda patolojik bulgu saptandığı görüldü. ICD kodları nın hastanın tanısından çok şikayetine göre girildiği saptandı.
Bronchiolectasis due to giant thoracic vertebral osteophytes
(Elsevier Science Inc, 2015) Ünlü, Elif Nisa; Büyükkaya, Ayla; Balbay, Ege Güleç
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Burnout Status of Health Care Personnel Working in Oncology and their Coping Methods
(Drunpp-Sarajevo, 2011) Balbay, Öner Abidin; Işıkhan, Vedat; Balbay, Ege Güleç; Annakkaya, Ali Nihat; Arbak, Peri Meram
Background: Working in oncology leads health care personnel (HCP) to feels stress, lack of satisfaction and to have psychological and physical problems and to be unproductive, estranged from job and to experience burnout. Objective: The aim of this study was to determine burnout state and the coping methods in HCP working in oncology. Methods: Interview Form, Maslach Burnout Inventory and Ways of Coping Inventory were administered total 444 HCP. Results: At the result of study HCP scored 1.76 in emotional exhaustion, 1.05 in depersonalization and 2.25 in lack of personal accomplishment [score range: 0-4]. These scores demonstrate that HCP experience moderate level burnout. It was established that HCP utilize mostly search for social support approach (X: 2.04) and they were least frequently found to use submissive approach (X: 0,97) [range: 0-3] in coping with burnout. It was established that, for emotional exhaustion nurses, other HCP who are consider their income inadequate and feel they have excessive work load form a risk group and for depersonalization with high education level, males, physicians, other HCP who are find their income inadequate run higher risk. It was also found that physicians and HCP with higher level of education, HCP who are feel themselves under excessive work load have a higher risk of experiencing lack of personal accomplishment. Conclusion: Our study demonstrated that it was not possible to avoid burnout in oncology clinics. The administrators should rapidly put into effect projects and regulations which may protect personnel from burnout.
A case with diffuse granulomatous inflammation mimicking malignancy [Maligniteyi taklit eden yaygın granülomatöz inflamasyon olgusu]
(Duzce University Medical School, 2017) Erçelik, Merve; Balbay, Ege Güleç; Arbak, Peri; Ataoğlu, Özlem
A 59-year-old female patient was admitted to outpatient clinic with a 3-week dry cough and a 2-month exercise dyspnea (MRC 2). Within the last 3 months there was a loss of 5 kg. She has never smoked. She was a housewife. In thoracic computed tomography of the patient’s postero-anterior chest x-ray, the right lower quadrant is the opacity of the right atrium. A large number of nodules (5 mm in size) in both upper lobes of the lungs, and a common reticulonodular dancer in the middle lobe of the right lingula. The desired positron emission tomography of the patient with malignancy pre-diagnosis; right lobe of the lungs, reticular densities in the left lung, gastroesophageal junction, stomach fundus and large curvature in the dorsal wall of the nasopharynx, bilateral cervical lymphadenopathies, bilateral cervical lymphadenopathies, bilateral lymph nodes, right lobe of the lungs, right scapula and left iliac bone intense hypermetabolic involvement was detected. The axillary lymph node dissection was diagnosed as granulomatous lymphadenitis. The patient was accepted as sarcoidosis, inhaled steroid therapy was initiated and followed. © 2017, Duzce University Medical School. All rights reserved.
The Clinical Correlations of Fatigue in Patients with Sarcoidosis
(2022) Gülhan, Pınar Yıldız; Balbay, Ege Güleç; Kumbasar, Özlem Özdemir; Erçelik, Merve; Annakkaya, Ali Nihat; Arbak, Peri Meram
Objective: Fatigue is considered a frequent and characteristic feature of sarcoidosis. This study was designed to determine the prevalence of fatigue in patients with sarcoidosis and to determine its potential clinical correlations in relation to symptom severity. Methods: A total of 56 sarcoidosis patients were included. Data on patient demographics, anthropometrics, disease characteristics, pulmonary function tests, 6-min walking distance (6MWD), blood biochemistry and hemogram findings were retrieved from hospital records. Psychometric instruments involved fatigue assessment scale (FAS), Beck Depression Inventory (BDI) and Short Form-36 (SF-36) for health-related QOL (HRQOL). Results: Mean±SD patient age was 50.9±11.9 years. Of 56 patients, 44 were females and 12 were males. When compared to FAS score <22 and FAS score ?22-34 subgroups, FAS score ?35 (severe fatigue) subgroup was associated with significantly higher patient age and significantly lower SF-36 physical health scores. Total FAS scores were correlated positively with age (r=0.349, p=0.008) and BDI scores (r=0.515, p<0.001), while negatively with MIP (r=-0.321, p=0.019) and SF-36 physical health (r=-0.402, p=0.003) and mental health (r=-0.351, p=0.009) scores. BDI score (OR 1.146, 95% CI: 1.020 to 1.288, p=0.021) was determined to be the single independent predictor of increased likelihood of a patient with sarcoidosis to have FAS score ?22. Conclusions: Our findings emphasize that deterioration in respiratory functions may contribute to development of fatigue among sarcoidosis patients, and besides the fatigue, depressive symptoms and anxiety should also be an integral part of the multidisciplinary management of sarcoidosis patients.
Deprem İlişkili Akciğer Hastalıkları; Yayınların Bibliyometrik Analizi
(2024) Balbay, Ege Güleç; Kurutkan, Mehmet Nurullah; Gülhan, Pınar Yıldız; Balbay, Öner
Amaç: Depreme bağlı akciğer hastalıkları (DİAH), afetin hem doğrudan hem de dolaylı sonucu olarak görülebilmektedir. Depremlerde yıkılan binalardan çıkan toz ve partiküllerin solunması, deprem sonrası oluşabilecek tsunami nedeniyle su ve patojenlerin aspirasyonu, pulmoner tromboembolizm, bulaşıcı solunum yolu hastalıkları ve göğüs travmaları gibi birçok DİAH gelişebilir. Bu bibliyometrik incelemenin amacı, DİAH yayınlarının entelektüel yapısını keşfetmektir. Gereç ve Yöntemler: DİAH alanıyla ilgili veri tabanları için bir arama stratejisi geliştirilmiştir. Web of Science veri tabanında 334 makaleye ulaşılmıştır. Tam metin okumaları sonucunda kalan 152 makale bibliyometrik yazılım ile atıf ve ortak atıf analizine tabi tutulmuştur. Bu araştırmaya ek olarak, alanın entelektüel yapısını incelemek için küme analizine dayalı metodolojiler kullanılmıştır. Bulgular: Yayınların yapıldığı zaman dilimine bakıldığında ilk yayının 1996 yılında yayınlandığı görülmektedir. İlk üç yazar incelendiğinde Yanai 6 yayın, Ueda 6 yayın ve Kobayashi 5 yayın ile sıralamayı paylaşıyor. Aynı zamanda bir deprem ülkesi olan Japonya 50 yayınla ilk sırada yer alıyor. Üç ana küme belirlenmiş olup, bu kümeler, “göğüs travmaları: tipleri, sıklıkları ve tıbbi müdahale stratejileri”, “depreme hazırlıklı olma ve depreme müdahale kapasitesi” ve “solunum yolu enfeksiyonları ve depremdir”. Sonuç: Bu araştırma, DİAH alanındaki depremler konusunda en etkili dergileri, yazarları ve ülkeleri belirlemenin yanı sıra, bu alandaki baskın araştırma temalarını da belirlemiştir. Araştırmamız DİAH alanını özetlemekte, gelecekteki araştırmalar için bir gündem sağlamakta ve deprem ile akciğer hastalıkları arasındaki ilişkinin daha derinlemesine çalışılmasına katkıda bulunmaktadır.
THE DISTRIBUTION OF FV-LEIDEN, PROTHROMBIN AND PLASMINOGEN ACTIVATOR INHIBITOR GENE MUTATIONS IN PATIENTS WITH OBSTRUCTIVE SLEEP APNEA
(Medecine Et Hygiene, 2014) Balbay, Ege Güleç; Küçük, Enes; Balbay, O.; Annakkaya, Ali Nihat; Sılan, Fatma; Çiçekliyurt, Meliha Merve
Aim: To investigate Factor V Leiden (FVL), Plasminogen Activator Inhibitor (PAI) or Prothrombin (F2L) gene polymorphisms among OSAS patients. Methods: 62 patients (35 male, 27 female) with the suspected diagnosis of OSAS were included. All patients filled out a questionnaire regarding sleep disturbance and underwent polysomnographic (PSG) examination. Genotypes were determined by a polymerase chain reaction and reverse hybridization. Results: The mean age was 51 +/- 12. 20 of the patients were not OSAS while 42 was OSAS. The distribution of FVL genotypes for 1691 GG, GA and AA is found 95 %, 5% and 0% in control group and 88.1%, 11.9% and 0% in patient groups (p:0.654) respectively. The mutant genotype was not observed for both FVL and F2L G20210A. The distribution of F2L 2021 GG, GA, AA was found 95%, 5% and 0% in control group while 97.6%, 2.4% and 0% in patient group (p:0.545) respectively. The genotype frequencies of the OSAS patients for PAT were 45.5% for wild, 45% for heterozygote, and 10% for homozygote mutant genotype in control group and 31% for wild, 47.6% for heterozygote, and 21.4% for homozygote mutant genotype in patient group (p:0.413). No significant associations with these three polymorphism were observed for OSAS and the data was shown as odds value for FVL, F2L respectively; ORFVL=2.5 (95% CI: 0.280-23.573), ORF2L =0.463 (95% CI: 0.027-7.811). Conclusion: Although FVL mutation was insignificantly high in OSAS patients, it may be an important risk factor in known hypercoagulabi-
Do We Question Occupational and Environmental Exposure Adequately in the Outpatient Clinic of Chest Diseases?
(2014) Balbay, Ege Güleç; Binay, Songül; Süner, Kezban Özmen; Çakıroğlu, Emine Banu; Arbak, Peri Meram
Amaç: Göğüs hastalıklarında öykü alma aşamasında, bireylerin mesleki ve çevresel maruziyetleri ile sigara kullanma öykülerini ayrıntılı olarak kaydetmek hastalık tanısında çok önem taşımaktadır. Bu çalışmada, göğüs hastalıkları polikliniğinde alınan meslek anamnezlerinin kalitesini araştırmak planlanmıştır. Yöntemler: Tıp fakültesi göğüs hastalıkları polikliniğine ayaktan başvurmuş 320 ardışık hastanın (158 kadın, 162 erkek) kayıtları retrospektif olarak değerlendirildi. Kayıtlarda bireylerin meslek öykü- lerinin ayrıntılı olarak alınıp alınmadığı, çevresel maruziyetlerin ve sigara kullanımının sorgulanma şekli değerlendirildi. Bulgular: Kadın hastaların yaş ortalaması 51,6173 iken, erkeklerinki 55,116,1 idi. En sık karşılaşılan meslekler; ev hanımı (%37,5), çiftçi (%12,8) ve işçi (%12,2) idi. Ayrıntılı meslek öyküsü %21,9 oranında alınmış ve erkeklerde (%79) kadınlardan (%31) daha yüksek oranda bulunmuştu (p0.001). İşçilerin %60'ında çalışılan işyeri sorgulanırken, halen çalışılan işten önceki işler %10,6 oranında sorgulanmıştı. Toplam 9 bireye (%2,8) yaşadığı ortam sorulmuştu. Sigara kullanımı olguların %90,6'sında sorgulanmıştı. Toplam 290 sigara kullanan olgunun 183'üne (%63,1) paket.yıl sorgulaması yapılmıştı. Sonuç: Göğüs hastalıkları polikliniğinde ayrıntılı mesleki anamnez, çevresel maruziyet öyküsü ve sigara kullanımı öyküsü kayıtlarının yeterli derecede yapılmadığı gözlenmiştir.
Does periodic lung screening of films meets standards?
(Professional Medical Publications, 2016) Binay, Songül; Arbak, Peri Meram; Şafak, Alp Alper; Balbay, Ege Güleç; Bilgin, Cahit; Karataş, Naciye
Objective: To determine whether the workers' periodic chest x-ray screening techniques in accordance with the quality standards is the responsibility of physicians. Evaluation of differences of interpretations by physicians in different levels of education and the importance of standardization of interpretation. Methods: Previously taken chest radiographs of 400 workers who are working in a factory producing the glass run channels were evaluated according to technical and quality standards by three observers (pulmonologist, radiologist, pulmonologist assistant). There was a perfect concordance between radiologist and pulmonologist for the underpenetrated films. Whereas there was perfect concordance between pulmonologist and pulmonologist assistant for over penetrated films. Results: Pulmonologist (52%) has interpreted the dose of the films as regular more than other observers (radiologist; 44.3%, pulmonologist assistant; 30.4%). The frequency of interpretation of the films as taken in inspiratory phase by the pulmonologist (81.7%) was less than other observers (radiologist; 92.1%, pulmonologist assistant; 92.6%). The rate of the pulmonologist (53.5%) was higher than the other observers (radiologist; 44.6%, pulmonologist assistant; 41.8%) for the assessment of the positioning of the patients as symmetrical. Pulmonologist assistant (15.3%) was the one who most commonly reported the parenchymal findings (radiologist; 2.2%, pulmonologist; 12.9%). Conclusion: It is necessary to reorganize the technical standards and exposure procedures for improving the quality of the chest radiographs. The reappraisal of all interpreters and continuous training of technicians is required.
THE EFFECT OF NATURAL GAS WARMING ON EMERGENCY APPLICATIONS DUE TO RESPIRATORY TRACT DISEASES IN CHILDREN IN DUZCE CITY
(Parlar Scientific Publications (P S P), 2019) Gülhan, Pınar Yıldız; Balbay, Ege Güleç; Annakkaya, Ali Nihat; Balbay, Öner Abidin; Arbak, Peri Meram
The use of natural gas for heating purposes causes less air pollution than solid fuels. Preventing air pollution decreases hospital admissions due to respiratory infections in children. The aim of the study is to examine the impact of using more clean fuel for heating purpose on hospital admissions with respiratory tract diseases in children. The records of 126.940 pediatric patients who were admitted to Duzce University Medical Faculty Pediatric Emergency Medicine outpatient clinic between 2014 and 2017 were reviewed. The records of children diagnosed with respiratory diseases (n: 46137) were examined. During the same period, air monitoring measurements of the national air quality network were recorded. Of the children, 55.5% were male and 45.5% were female. Most of the children were among the age group of 2-5 years (44%). Between 2014 and 2017, the mean PM10 was observed to decrease (2014: 114.4, 2017:79, p < 0.0001), rate of natural gas usage (2014:52.9%, 2017: 64.2%, p<0.0001) increased, rates of stove usage (2014:47%-2017:35.7%, p<0.0001) decreased, annual mean air temperature values (2014:13.9-2017:16.7, p<0.0001) increased significantly. When all pediatric emergency admissions between 2014 and 2017 were examined, the number of those diagnosed with respiratory tract disease reduced while the number of general pediatric emergency admissions increased. The use of more clean fuels for heating purposes was observed to decrease the incidence of acute respiratory tract infections significantly in the preschool and school age group children. The use of clean fuel should be encouraged since preventing childhood infections would protect from the chronic lung diseases that may occur during adulthood.
The Effect of Obstructive Sleep Apnea on Violent and Non-violent Behavior
(2020) Gülhan, Pınar Yıldız; Elverişli, Mehmet Fatih; Cangür, Şengül; Balbay, Ege Güleç; Buken, Bora
Aim: Obstructive sleep apnea (OSA) characterized by repetitive collapse of the upper airway during sleep and thiscondition leading to oxygen desaturation, sympathetic activation, and recurrent arousals. Patients who experience sleepproblems consider themselves, less able to control impulsive, aggressive tendencies. The aim of this study was toinvestigate the effect of OSA and daytime sleepiness on violent and non-violent behaviors.Material and Methods: Hundred fifty individuals who were admitted to the Chest Disease Polyclinic for SleepDisorders of Duzce University, School of Medicine Hospital were included in the study. All patients underwentpolysomnography (PSG). All tests [Beck Depression Inventory (BDI), Beck Anxiety Inventory (BAI), EpworthSleepiness Scale (ESS) and Nonviolent and Violent Offending Behavior Scale (NVOBS)] were applied to allparticipants by face to face interview.Results: In this study, no significant relationship was found between NVOBS and AHI in OSA patients. Patients withOSA; There was a significant relationship between total score of NVOBS and ESS (r=0.267 p=0.003). There was asignificant relationship between the ESS score and the BDI score (r=0.314 p <0.001) and BDI scale (r=0.319 p <0.001)scores.Conclusions: There was no significant relationship between violent and non-violent behaviors and AHI. However,there was a significant relationship between ESS and BDI, BAI and NVOBS. There may be commonneurophysiological activation mechanisms of sleep and violence action. Today, violent behavior and sleep problemsincrease and further research is needed to investigate the relationship between sleep problems and violent behavior.
The effect of particular matter pollution on emergency room visits due to COPD and asthma and the association with hospitalization rate in Duzce City
(European Respiratory Soc Journals Ltd, 2012) Balbay, Ege Güleç; Arbak, Peri Meram; Balbay, Öner Abidin; Annakkaya, Ali Nihat
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The effects of Two Sequential Earthquakes on Tuberculosis Patients: An Experience from Duzce Earthquake
(Drunpp-Sarajevo, 2011) Balbay, Öner Abidin; Balbay, Ege Güleç; Arbak, Peri Meram; Annakkaya, Ali Nihat; Bilgin, Cahit
Setting: Duzce city, a rural area in the northwest part of Turkey. Objectives: To examine the effects of two sequential earthquakes on sociodemographic and disease related features of tuberculosis (TB) patients. Methods: The present study was conducted among newly diagnosed smear positive (from October 1998 to October 2002) 112 pulmonary TB patients based on a specific questionnaire. Patients were divided into 3 groups regarding the time of diagnosis and the period from the initiation to the end of the treatment (pre, peri and post-earthquake periods). Results: Although the present study has not focused on the factors that influence the adherence of patients to TB therapy, no major changes were observed regarding socio-economical parameters that have an effect on the fate of TB. Patients were frequently hospitalized in pre-earthquake period while patients were ambulatory in peri and post-earthquake period (p<0.005). Patients were significantly controlled once a month in peri-earthquake period (p<0.001). Patients were mostly followed by the same doctor in post-earthquake period. Conclusion: It can be stated that the earthquakes had very little impact on the TB during and after earthquakes in Duzce. Further studies including whole Marmara region are needed to interpret the effect of earthquake on TB control.
Erdosteine protects rat testis tissue from hypoxic injury by reducing apoptotic cell death
(Wiley, 2014) Güven, Aysel; İçkin, Meletm; Uzun, O.; Bakar, Coşkun; Balbay, Ege Güleç; Balbay, O.
The purpose of this study was to examine the effects of hypobaric hypoxia on testis morphology and the effects of erdosteine on testis tissue. Caspase-3 and hypoxia-inducible factor 1 expressions were detected by immunohistochemistry. Adult male Wistar rats were placed in a hypobaric hypoxic chamber. Rats in the erdosteine group were exposed to the same conditions and treated orally with erdosteine (20mgkg(-1) daily) at the same time from the first day of hypoxic exposure for 2weeks. The normoxia group was evaluated as the control. The hypoxia group showed decreased height of spermatogenic epithelium in some seminiferous tubules, vacuolisation in spermatogenic epithelial cells, deterioration and gaps in the basal membrane and an increase in blood vessels in the interstitial area. The erdosteine group showed amelioration of both epithelial cell vacuolisation and basal membrane deterioration. Numbers of hypoxia-inducible factor 1-immunostained Sertoli and Leydig cells were significantly higher in the hypoxia group than in the erdosteine group. The number of seminiferous tubules with caspase-3-immunostained germ cells was highest in the hypoxia group and decreased in the erdosteine and normoxia groups respectively. Based on these observations, erdosteine protects testis tissue from hypoxic injury by reducing apoptotic cell death.
The Evaluation of Eating Attitudes in Patients with Sarcoidosis
(2020) Gülhan, Pınar Yıldız; Ataoğlu, Özlem; Balbay, Ege Güleç; Yaşlı, Nevra Ezgi; Annakkaya, Ali Nihat
Objective: The aim of this present study was to investigate the eating attitudes ofsarcoidosis patients.Methods: 50 patients with sarcoidosis and 45 healthy individuals without chronicdisease were included to study. All participants evaluated for metabolic syndrome(MetS) according to National Cholesterol Education Program's Adult Treatment PanelIII (NCEP-ATP III) criteria. Eating Attitude Test (EAT) and Beck DepressionInventory (BDI) were applied to all participants. All participants evaluated formetabolic syndrome (MetS). The cut-off scores of the tests were 30 for BDI and 17for BDI.Results: When sarcoidosis cases and control group were evaluated according to EATand BDI cut-off scores; it was found that the prevalence of deterioration in eatingbehavior was higher in patients with sarcoidosis than healthy controls but theprevalence of depression was not higher (p=0.018, p=0.874 respectively).We foundthat total EAT scores were significantly higher in sarcoidosis patients who has MetS.MetS(-); EAT: 15±7, MetS(+); EAT: 27±10 p<0.001.Conclusions: This study is important to show connection between the sarcoidosis anddisordered eating attitudes. It is not adequate to establish the presence ofcomorbidities alone. Defining risk factors leading to comorbidities is also important inpatients with sarcoidosis. If causative factors are detected, controlling them by amultidisciplinary approach will prevent the onset of comorbidities and also providesatisfactory management of sarcoidosis.
Evaluation of Intraocular pressure, Corneal thickness, and Retinal nerve fiber layer thickness in patients with Obstructive Sleep Apnea Syndrome
(Professional Medical Publications, 2018) Teberik, Kuddusi; Eski, Mehmet Tahir; Balbay, Ege Güleç; Kaya, Murat
Objective: To evaluate the intraocular pressure (IOP), central corneal thickness (CCT), and peripapillary retinal nerve fiber layer (RNFL) thickness in Patients with Obstructive Sleep Apnea Syndrome. Methods: In this prospective study, 103 patients with OSAS (study group) and 37 healthy subjects were enrolled. All participants underwent comprehensive ophthalmic examinations. Mean outcome measures were intraocular pressure by Goldmann applanation tonometry, CCT measurement using ultrasound pachymeter and peripapillary RNFL thickness measured by spectral-domain optical coherence tomography. Results: The differences between the mean values of RNFL thickness in all quadrants were similar in both groups and were not statistically significant (p=0.274). The IOP and CCT measurement averages of all patients with OSAS were lower than the control group. However, this difference was not statistically significant. There was no correlation between the apnea-hypopnea index, lowest oxygen saturation (LAST) or Body Mass Index (BMI) and the peripapillary RNFL thickness, IOP or CCT when OSAS group was divided by severity. Conclusions: The study results suggest that peripapillary RNFL thickness, IOP or CCT did not differ significantly between OSAS and control groups. We also found no correlation between apnea severity (AHI), lowest oxygen saturation (LAST) and BMI and RNFL, CCT and IOP.

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