Multidrug resistance-1 gene C3435T single nucleotide polymorphism in OSAS patients

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dc.contributor.authorAyada, Ceylan
dc.contributor.authorErbay, Ümran Toru
dc.contributor.authorAnnakkaya, Ali Nihat
dc.date.accessioned2020-04-30T23:19:24Z
dc.date.available2020-04-30T23:19:24Z
dc.date.issued2019
dc.departmentDÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.descriptionWOS: 000512905300018en_US
dc.description.abstractAim: Obstructive sleep apnea syndrome (OSAS) is characterized by decreased airflow (hypopnea) or complete interruption (apnea) and is characterized by airway narrowing, decreased oxyhemoglobin saturation, hypercapnia, and hyperventilation associated therewith. It is known that genetic factors play role in the pathogenesis of OSAS. Multi-drug resistant-1 (MDR-1) gene products have a role in the pathogenesis of several diseases related to oxidative stress. We aimed to evaluate the frequency of MDR-1 gene C/T polymorphism in patients with OSAS. Material and Method: This study was performed on 43 OSAS and 23 healthy individuals. Blood samples from each individual were collected in tubes with ethylenediaminetetraacetic add (EDTA). DNA was extracted from the blood samples. The MDR-1 gene polymorphism was detected by polymerase chain reaction (PCR) and enzyme digestion techniques. Results: The frequencies of MDR-1 genotypes were found 27.9% for CC, 41.9% for CT and 30.2% for TT in the OSAS group and 17.4% for CC, 65.2% for CT and 17.4% for TT in the control group. The distribution of MDR-1 gene C alleles was found to be 48.8% in COPD group and 50.0% in the control group; T alleles were found to be 51.2% in OSAS group and 50.0% in the control group. There was no statistically significant difference observed between the groups for genotype and allele frequency of MDR-1 gene (p>0.05). Discussion: We believe these results can be useful for large-scale population genetic research considering the frequency of the MDR-1 gene variation in OSAS patients in the Turkish population.en_US
dc.identifier.doi10.4328/ACAM.6072en_US
dc.identifier.endpage605en_US
dc.identifier.issn2667-663X
dc.identifier.issue5en_US
dc.identifier.startpage602en_US
dc.identifier.urihttps://doi.org/10.4328/ACAM.6072
dc.identifier.urihttps://hdl.handle.net/20.500.12684/3743
dc.identifier.volume10en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherBayrakol Medical Publisheren_US
dc.relation.ispartofAnnals Of Clinical And Analytical Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectObstructive Sleep Apnea Syndrome (OSAS)en_US
dc.subjectMulti-Drug Resistant-1 (MDR-1) Geneen_US
dc.subjectC3435T Single Nucleotide Polymorphismen_US
dc.subjectTurkish Populationen_US
dc.titleMultidrug resistance-1 gene C3435T single nucleotide polymorphism in OSAS patientsen_US
dc.typeArticleen_US

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