Nanoconjugate formulations for enhanced drug delivery

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dc.authorscopusid57208525350en_US
dc.authorscopusid57203248807en_US
dc.authorscopusid57192876108en_US
dc.authorscopusid57193741014en_US
dc.contributor.authorOner, E.
dc.contributor.authorIlhan, M.
dc.contributor.authorGultekin, H.E.
dc.contributor.authorKarpuz, M.
dc.date.accessioned2024-08-23T16:07:39Z
dc.date.available2024-08-23T16:07:39Z
dc.date.issued2023en_US
dc.departmentDüzce Üniversitesien_US
dc.description.abstractNanoconjugate is the nanosized drug delivery system, which consists of a drug molecule or a drug-loaded carrier attached to a moiety covalently or noncovalently. There is a growing interest in these versatile nanoconjugates due to their suitability to design with moieties improving the efficacy and safety of drugs by targeting the desired location in the body, increasing solubility or stability, and controlling the release conditions. Today, many nanoconjugate formulations have entered the market to diagnose and treat several diseases, especially cancer. Antibody-drug conjugate pipeline has been widened with cutting-edge manufacturing technologies. Carbohydrate-conjugated therapeutic nucleic acid elements of RNA interference and antisense technologies open a new era to treat liver-associated diseases. Also, nanoconjugate formulations formed with other moieties, such as polymers, peptides, oligonucleotides, gold nanoparticles, and lipids, show promising results to be used in the clinic. This chapter summarizes the strategies used in these nanoconjugate systems to enhance drug delivery. Besides, a comprehensive review of the main types of drug conjugates (including polymer-, peptide-, antibody-, nucleic acid-, carbohydrate-, lipid-drug conjugates) used for conventional therapy, nucleic acid therapy, imaging, diagnosis, and theranostic applications is presented together with the latest preclinical studies, clinical trials, and approvals. © 2023 Elsevier Inc. All rights reserved.en_US
dc.identifier.doi10.1016/B978-0-323-91668-4.00023-X
dc.identifier.endpage491en_US
dc.identifier.isbn978-032391668-4en_US
dc.identifier.isbn978-032397219-2en_US
dc.identifier.scopus2-s2.0-85176828835en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage441en_US
dc.identifier.urihttps://doi.org/10.1016/B978-0-323-91668-4.00023-X
dc.identifier.urihttps://hdl.handle.net/20.500.12684/14766
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofAdvanced and Modern approaches for Drug Deliveryen_US
dc.relation.publicationcategoryKitap Bölümü - Uluslararasıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAntibody-drug conjugatesen_US
dc.subjectConjugation strategiesen_US
dc.subjectNanoconjugates for gene deliveryen_US
dc.subjectNanoconjugates for imagingen_US
dc.subjectPeptide-drug conjugatesen_US
dc.subjectPolymer-drug conjugatesen_US
dc.subjectTheranostic nanoconjugatesen_US
dc.subjectTherapeutic nanoconjugatesen_US
dc.titleNanoconjugate formulations for enhanced drug deliveryen_US
dc.typeBook Chapteren_US

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