Caffeine Habituation, not CYP1A2 Genotype, Modulates the Acute Effect of Caffeine on Exercise-Induced Hemostatic Responses in Adults with Obesity

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dc.contributor.authorSajedi, Heidar
dc.contributor.authorAydin, Elif
dc.contributor.authorKeskin, Ozlem
dc.contributor.authorErcis, Sertaç
dc.contributor.authorAkpinar, Selahattin
dc.contributor.authorKhodadadi, Davar
dc.date.accessioned2025-10-11T20:45:25Z
dc.date.available2025-10-11T20:45:25Z
dc.date.issued2025
dc.departmentDüzce Üniversitesien_US
dc.description.abstractPurpose This study aimed to investigate how genotype and caffeine habituation influence the acute effects of caffeine ingestion on exercise-induced hemostatic responses in individuals with obesity. Methods Using a randomized, double-blind, placebo-controlled crossover design, 40 physically inactive young men with obesity (age, 22.2 ± 2.3 years; BMI, 34.1 ± 2.7 kg/m2) completed two moderate-to-high-intensity concurrent exercise sessions following ingestion of caffeine (3 mg/kg) or placebo. Blood samples were collected at baseline, after exercise, and after 60 minutes of recovery. Statistical analysis was performed by repeated measures MANOVA. Results Acute exercise increased platelet count and aggregation, fibrinogen, F1 + 2, tPA antigen, D-dimer, and clot lysis time, regardless of genotype or caffeine habituation status (P < 0.05). PAI-1 antigen remained unchanged after exercise (P > 0.05) but decreased following recovery (P < 0.01). Caffeine resulted in a greater increase in platelet aggregation, fibrinogen, F1 + 2, and clot lysis time, alongside a blunted increase in tPA antigen levels post-exercise in naïve consumers (P < 0.05). In contrast, habitual caffeine consumers exhibited a mitigated increase in clot lysis time and a greater post-recovery reduction in PAI-1 antigen following caffeine ingestion (P < 0.001). Caffeine's impact on hemostatic responses to exercise was unaffected by genotype (P > 0.05). Conclusions Moderate-to-high-intensity concurrent exercise induces a transient prothrombotic state in physically inactive individuals with obesity. Acute caffeine supplementation at a moderate dose modulates the hemostatic responses depending on caffeine habituation status rather than CYP1A2 genotype: it exacerbates the prothrombotic response in naïve consumers but attenuates it in habitual consumers. © 2025 Elsevier B.V., All rights reserved.en_US
dc.identifier.doi10.1249/MSS.0000000000003816
dc.identifier.issn0195-9131
dc.identifier.issn1530-0315
dc.identifier.scopus2-s2.0-105010770774en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1249/MSS.0000000000003816
dc.identifier.urihttps://hdl.handle.net/20.500.12684/21346
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherLippincott Williams and Wilkinsen_US
dc.relation.ispartofMedicine and Science in Sports and Exerciseen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmzKA_Scopus_20250911
dc.subjectCaffeineen_US
dc.subjectCoagulationen_US
dc.subjectConcurrent Exerciseen_US
dc.subjectFibrinolysisen_US
dc.subjectObesityen_US
dc.subjectPlatelet Aggregationen_US
dc.titleCaffeine Habituation, not CYP1A2 Genotype, Modulates the Acute Effect of Caffeine on Exercise-Induced Hemostatic Responses in Adults with Obesityen_US
dc.typeArticleen_US

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