Factors associated with glomerular filtration rate variation in primary hyperparathyroidism after parathyroidectomy

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dc.authorid
dc.contributor.authorÇalışkan, Mustafa
dc.contributor.authorKızılgül, Muhammed
dc.contributor.authorBeysel, Selvihan
dc.contributor.authorUçan, Bekir
dc.contributor.authorAkcan, Fatih Alper
dc.contributor.authorTakır, Mümtaz
dc.contributor.authorÇakal, Erman
dc.date.accessioned2021-12-01T18:23:44Z
dc.date.available2021-12-01T18:23:44Z
dc.date.issued2019
dc.department[Belirlenecek]en_US
dc.description.abstractBackground/aim: Prolonged hypercalcemia impairs renal function, and a reduced glomerular filtration rate (GFR) is typical in advancedprimary hyperparathyroidism (PHPT). There are scarce data related to predictors of renal impairment in patients with PHPT. Hence,we aimed to evaluate changes in kidney function in PHPT patients after parathyroidectomy (PTX) and identify factors associated withGFR variation in these patients.Materials and methods: One hundred and twenty-five patients with PHPT who underwent surgery between 2012 and 2014 wereenrolled in the study. Patients were divided into two groups according to GFR values: patients whose GFR was lower than 60 mL/min/1.73 m2 and higher than 60 mL/min/1.73 m2. Demographic and laboratory parameters were compared before and 6 months afterparathyroidectomy.Results: Prevalence of antihypertensive drug users and patients with renal cysts and parathormone (PTH) and alkaline phosphataselevels were higher in patients with GFR of ?60 than in GFR of <60 mL/min/1.73 m2 (P < 0.05). Systolic BP, uric acid, and magnesium weredecreased in patients with GFR of ?60, but GFR did not change in the two groups after parathyroidectomy. After parathyroidectomy,calcium and PTH decreased but 25(OH)D3 and phosphorus increased in the two groups. In multiple regression analysis, age, calcium,and baseline GFR were independent predictors of GFR variation. Parathyroid adenoma volume and urinary calcium were notindependent predictors of GFR change.Conclusion: Older age, higher preoperative calcium, and GFR were factors associated with GFR increase in PHPT patients afterparathyroidectomy. Further renal impairment was prevented by parathyroidectomy in PHPT patients.en_US
dc.identifier.doi10.3906/sag-1806-181
dc.identifier.endpage300en_US
dc.identifier.issn1300-0144
dc.identifier.issn1303-6165
dc.identifier.issue1en_US
dc.identifier.startpage295en_US
dc.identifier.urihttps://doi.org/10.3906/sag-1806-181
dc.identifier.urihttps://app.trdizin.gov.tr/makale/TXpNMU9UWTBOQT09
dc.identifier.urihttps://hdl.handle.net/20.500.12684/9763
dc.identifier.volume49en_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.relation.ispartofTurkish Journal of Medical Sciencesen_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCerrahien_US
dc.titleFactors associated with glomerular filtration rate variation in primary hyperparathyroidism after parathyroidectomyen_US
dc.typeArticleen_US

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