The levels of asymmetric dimethylarginine in patients with isolated coronary artery ectasia

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dc.contributor.authorErden, İsmail
dc.contributor.authorErden, Emine Çakcak
dc.contributor.authorSözen, Serhat Bahadır
dc.contributor.authorKayapınar, Osman
dc.contributor.authorÇağlar, Sabri Onur
dc.contributor.authorBaşar, Cengiz
dc.date.accessioned2020-04-30T13:33:45Z
dc.date.available2020-04-30T13:33:45Z
dc.date.issued2010
dc.departmentDÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractAim: Although underlying mechanisms of coronary artery ectasia (CAE) are clearly unknown, endothelial dysfunction may be responsible for the coronary ectasia. Asymmetric dimethylarginine (ADMA) is the principal endogenous inhibitor of nitric oxide synthase and elevated levels of ADMA is considered to be a marker of endothelial dysfunction and increased risk of cardiovascular disease. Accordingly, we investigated serum ADMA levels in patients with CAE in comparison with participants having normal coronary artery. Method: This study consisted of 41 consecutive patients with angiographically proven normal coronary arteries with CAE and 48 controls with normal coronary arteries without coronary artery ectasia undergoing cardiac catheterization. Serum levels of ADMA were measured by Enzyme Linked Immunosorbent Assay. Result: Serum level of ADMA was significantly higher in CAE patients compared with controls (1.9±0.9 ?mol/l vs. 1.1±0.7 ?mol/l, respectively, p= 0.01). Serum ADMA levels was an independent predictor for CAE (OR= 1.486 [95% confidence interval (CI): 0.978-2.054; p= 0.03]). ADMA levels correlated with diffuse ectasia (p= 0.04). Conclusion: Our findings provide evidence to support the hypothesis that endothelial dysfunction may be an important factor in the pathogenesis of CAE.en_US
dc.identifier.endpage409en_US
dc.identifier.issn1304-3889
dc.identifier.issue4en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage404en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12684/722
dc.identifier.volume7en_US
dc.indekslendigikaynakScopusen_US
dc.language.isotren_US
dc.relation.ispartofEuropean Journal of General Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAsymmetric dimethylarginine; Coronary artery; Ectasiaen_US
dc.titleThe levels of asymmetric dimethylarginine in patients with isolated coronary artery ectasiaen_US
dc.title.alternativeİzole Koroner Arter Ektazili Hastalarda Asymmetric Dimethylarginine Seviyelerien_US
dc.typeArticleen_US

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