Effects of erdosteine on alpha amanitin-induced hepatotoxicity in mice

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dc.contributor.authorKaya, Ertuğrul
dc.contributor.authorYılmaz, İsmail
dc.contributor.authorAdmış, Özlem
dc.contributor.authorOktay, Murat
dc.contributor.authorBayram, Recep
dc.contributor.authorBakırcı, Sinan
dc.contributor.authorÇolakoğlu, Serdar
dc.date.accessioned2020-04-30T13:32:24Z
dc.date.available2020-04-30T13:32:24Z
dc.date.issued2016
dc.departmentDÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractThe aim of this study was to investigate beneficial effects of erdosteine in the alpha amanitine-induced hepatotoxicity in mice. Three hours after giving alpha amanitin (0.5 mg/kg, i.p.) to the mice, they were administered silibinin (50 mg/kg/d, i.p.) or erdosteine (100 mg/kg/d, oral) therapies once a day for 3 d. A histopathological examination of their liver tissues was carried out 24 h after the last treatment; transaminase levels, blood urea nitrogen, urea, and creatinine were analyzed in serum. Erdosteine showed a beneficial effect by significantly improving the functional parameters particularly in alpha amanitin-induced hepatotoxicity and partially in renal toxicity. In the histopathological evaluation, the toxicity that was generated with alpha amanitin was significantly reduced by erdosteine, showing a possible hepatoprotective effect. © 2016 Informa UK Limited, trading as Taylor & Francis Group.en_US
dc.identifier.doi10.1080/15569543.2016.1178146en_US
dc.identifier.endpage9en_US
dc.identifier.issn1556-9543
dc.identifier.issue01.Feben_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage4en_US
dc.identifier.urihttps://dx.doi.org/10.1080/15569543.2016.1178146
dc.identifier.urihttps://hdl.handle.net/20.500.12684/271
dc.identifier.volume35en_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherTaylor and Francis Ltden_US
dc.relation.ispartofToxin Reviewsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAmanitin; erdosteine; hepatoprotection; hepatotoxicity; silibininen_US
dc.titleEffects of erdosteine on alpha amanitin-induced hepatotoxicity in miceen_US
dc.typeArticleen_US

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