Metabolik sendrom ve insülin direnci olan hastalarda ortalama trombosit hacmi düzeyi
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Dosyalar
Tarih
2011
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Düzce Üniversitesi
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Amaç: Metabolik sendrom (MS), insülin direnci temelinde ortaya çıkan, klinik tablosunda proinflamatuar ve protrombotik öğeleri bulunduran, kardiyovasküler hastalık riskinin artışı ile ilişkili risk faktörü topluluğudur. Çalışmamızda, metabolik sendrom ve insülin direnci bulunan hastalarda kardiyovasküler risk faktörlerinden biri olan ortalama trombosit hacmi (MPV) düzeyleri ile MS komponentleri arasındaki ilişkinin değerlendirilmesi amaçlandı.Materyal-metod: Bu çalışmaya, Kasım 2010 - Ocak 2011 tarihleri arasında Düzce Üniversitesi Endokrinoloji ve Dahiliye Polikliniğine başvuran 122 hasta ve 38 sağlıklı kontrol grubu alındı. Obez hastalardan oluşan vaka grubu MS kriterleri ve insülin direncine göre üç gruba ayrıldı. Hastaların bel/kalça oranı, vücut kitle indeksi, sistolik ve diyastolik kan basıncı, trigliserid, LDL kolesterol, HDL kolesterol, açlık kan şekeri, insülin, HbA1c ve MPV ölçümleri yapıldı. HOMA değerleri hesaplandı.Bulgular: MS'lu hastalarda kontrol grubuna göre, tüm MS parametrelerinde istatistiksel olarak anlamlı yükseklik mevcuttu. İnsülin direnci olan grupta vücut kitle indeksi, sistolik ve diyastolik tansiyon, trigliserid, LDL kolesterol, açlık kan şekeri, insülin, HbA1c, HOMA-IR, ürik asit, hsCRP değerleri diğer gruplara göre istatistiksel olarak anlamlı yüksek bulundu (p<0,05). Multiple lineer regresyon analizinde hepatosteatoz varlığı ile VKİ, HOMA-IR, ALT ve LDL kolesterol düzeyleri arasında pozitif anlamlı ilişki saptandı. Olguların MPV sonuçları incelendiğinde gruplar arasında istatistiksel olarak anlamlı farklılık bulunamadı.Sonuç: Çalışmamızda kardiyovasküler hastalık ve trombotik olaylar açısından risk faktörü olduğu öne sürülen MPV'nin MS ve içerdiği kriterlerle ilişkisinin olmadığı gösterilmiştir. MPV'nin metabolik sendromlu hastaların takibinde ve mikrovasküler komplikasyon riskinin tahmin edilmesinde etkinliğinin değerlendirilmesi için daha büyük çaplı ve uzun süreli çalışmalara ihtiyaç olduğu kanaatindeyiz.
Purpose: Metabolic syndrome (MS), emerged in the basis of insulin resistance, is a collection of risk factors associated with an increased risk of cardiovascular disease in which there is a clinical picture containing proinflammatory and prothrombotic items. In our study, in patients with metabolic syndrome and insulin resistance, the association between the metabolic syndrome components and the levels of mean platelet volume (MPV) which is one of the cardiovascular risk factors aimed to be evaluated.Material and method: In this study 122 patients and 38 healthy control subjects admitted to the Duzce University Endocrinology and Internal Medicine clinics between November 2010 ? January 2011 included. The case group of patients, who were obese, divided into three groups according to MS criteria and insulin resistance. Patients waist/hip ratio, body mass index, systolic and diastolic blood pressure, triglyceride, LDL cholesterol, HDL cholesterol, fasting blood glucose, insulin, HbA1c, and MPV were measured. HOMA values were calculated.Results: In the all parameters of the MS there was statistically significant elevation in patients in metabolic syndrome than the control group. In the group with insulin resistance, body mass index, systolic and diastolic blood pressure, triglyceride, LDL cholesterol, fasting blood glucose, insulin, HbA1c, HOMA-IR, uric acid, hsCRP values were found significantly higher than the other groups (p<0.05). In multiple regression analysis with the presence of hepatosteatosis, a positive significant relationship was found between the values of BMI, HOMA-IR, ALT, and LDL cholesterol levels. When the MPV results of the cases were examined, there was not any statistically significant differences found in between the groups.Conclusion: In our study, MPV which is suggested as a risk factor for cardiovascular disease and thrombotic events have shown to be no relationship with MS and its criterias. We believe that to evaluate the efficacy of MPV in the follow-up of patients with metabolic syndrome and predicting the risk of microvascular complications, large-scale and long-term studies are needed.
Purpose: Metabolic syndrome (MS), emerged in the basis of insulin resistance, is a collection of risk factors associated with an increased risk of cardiovascular disease in which there is a clinical picture containing proinflammatory and prothrombotic items. In our study, in patients with metabolic syndrome and insulin resistance, the association between the metabolic syndrome components and the levels of mean platelet volume (MPV) which is one of the cardiovascular risk factors aimed to be evaluated.Material and method: In this study 122 patients and 38 healthy control subjects admitted to the Duzce University Endocrinology and Internal Medicine clinics between November 2010 ? January 2011 included. The case group of patients, who were obese, divided into three groups according to MS criteria and insulin resistance. Patients waist/hip ratio, body mass index, systolic and diastolic blood pressure, triglyceride, LDL cholesterol, HDL cholesterol, fasting blood glucose, insulin, HbA1c, and MPV were measured. HOMA values were calculated.Results: In the all parameters of the MS there was statistically significant elevation in patients in metabolic syndrome than the control group. In the group with insulin resistance, body mass index, systolic and diastolic blood pressure, triglyceride, LDL cholesterol, fasting blood glucose, insulin, HbA1c, HOMA-IR, uric acid, hsCRP values were found significantly higher than the other groups (p<0.05). In multiple regression analysis with the presence of hepatosteatosis, a positive significant relationship was found between the values of BMI, HOMA-IR, ALT, and LDL cholesterol levels. When the MPV results of the cases were examined, there was not any statistically significant differences found in between the groups.Conclusion: In our study, MPV which is suggested as a risk factor for cardiovascular disease and thrombotic events have shown to be no relationship with MS and its criterias. We believe that to evaluate the efficacy of MPV in the follow-up of patients with metabolic syndrome and predicting the risk of microvascular complications, large-scale and long-term studies are needed.
Açıklama
YÖK Tez No: 282070
Anahtar Kelimeler
Endokrinoloji ve Metabolizma Hastalıkları, Endocrinology and Metabolic Diseases, Metabolik hastalıklar, Metabolic diseases, Trombosit sayısı, Platelet count, İnsülin direnci, Insulin resistance, Metabolik sendrom, insülin direnci, ortalama trombosit hacmi, Methabolic syndrome, insüline resistance, mean platelet volume
