Renal fonksiyonları normal tip 2 diyabetli hastalarda serum ürik asit düzeyleri
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Tarih
2007
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Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Bu çalışmanın amacı ürik asidin henüz nefropati gelişmemiş diyabetli hastalarda artıp artmadığını ve serum ürik asit düzeyleri ile hipertansiyon ve renal bozukluk haricinde diyabette glisemi kontrolü ve başka parametrelerle ilişkili olup olmadığını araştırmaktı. Çalışmaya 55 yeni tanı konulmuş tip 2 diyabet hastası ve 41 sağlıklı gönüllü dahil edildi. Diyabetli grupla kontrol grubu arasında serum kreatinin düzeyleri, total kolesterol düzeyleri, düşük dansiteli lipoprotein-kolesterol düzeyleri, vücut kitle indeksi, yaş ve arteriyel kan basınçları arasında istatistiksel olarak fark bulunmadı (p0.05). Ancak diyabetli grubun ortalama serum ürik asit düzeyleri (4.6 1.5 mg/dL) kontrol grubundan (5.3 1.7 mg/dL) anlamlı şekilde düşük bulundu (p0.05). Ayrıca diyabet grubunda, serum ürik asit düzeyi ile çalışılan diğer parametreler arasında anlamlı korelasyon bulunamazken, kontrol grubunda serum ürik asit düzeyi ile sistolik kan basıncı, diyastolik kan basıncı, açlık kan glukozu, hemoglobin A1C ve vücut kitle indeksi arasında pozitif korelasyonlar bulundu (p0.05). Diyabette azalmış ürik asit düzeylerinin pek çok faktöre bağlı olduğunu düşünmekteyiz. Ayrıca diyabetteki oksidatif strese ürik asit azalmasının da katkısı olabilir.
The aim of this study was to investigate whether serum uric acid levels increase in Diabetes Mellitus and if serum uric acid levels were related to factors apart from hypertension and renal failure. Fifty-five newly diagnosed patients with type 2 Diabetes Mellitus and 41 healthy volunteers were included in the study. Serum creatinin level, total cholesterol level, low density lipoprotein-cholesterol level, body mass index, age, and arterial blood pressure was not different in diabetic group, when compared with the control group. However, serum uric acid level (4.6 ± 1.5 mg/dL) was significantly lower than those of the control group (5.3 ± 1.7 mg/dL) (p<0.05). In addition, uric acid in the diabetic group did not significantly correlate with the biochemical and clinical variables, whereas in the control group, serum uric acid level was significantly correlated with systolic blood pressure, diastolic blood pressure, fasting blood glucose level, hemoglobin A1C level and body mass index. We think that decreased serum uric acid level in diabetes is dependent on many factors. In addition, the decrease of serum uric acid level may be contributed to oxidative stress in diabetes.
The aim of this study was to investigate whether serum uric acid levels increase in Diabetes Mellitus and if serum uric acid levels were related to factors apart from hypertension and renal failure. Fifty-five newly diagnosed patients with type 2 Diabetes Mellitus and 41 healthy volunteers were included in the study. Serum creatinin level, total cholesterol level, low density lipoprotein-cholesterol level, body mass index, age, and arterial blood pressure was not different in diabetic group, when compared with the control group. However, serum uric acid level (4.6 ± 1.5 mg/dL) was significantly lower than those of the control group (5.3 ± 1.7 mg/dL) (p<0.05). In addition, uric acid in the diabetic group did not significantly correlate with the biochemical and clinical variables, whereas in the control group, serum uric acid level was significantly correlated with systolic blood pressure, diastolic blood pressure, fasting blood glucose level, hemoglobin A1C level and body mass index. We think that decreased serum uric acid level in diabetes is dependent on many factors. In addition, the decrease of serum uric acid level may be contributed to oxidative stress in diabetes.
Açıklama
Anahtar Kelimeler
Biyokimya ve Moleküler Biyoloji
Kaynak
Türk Biyokimya Dergisi
WoS Q Değeri
Scopus Q Değeri
Cilt
32
Sayı
2
