Sepsis Multi Organ Damage Due To Secondary Immune Failure After Spondylodiscitis

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dc.authorscopusid57869558200en_US
dc.authorscopusid6505842146en_US
dc.authorscopusid6506761436en_US
dc.contributor.authorŞenoglu, G.D.
dc.contributor.authorDemiraran, Y.
dc.contributor.authorYazar, Z.
dc.date.accessioned2024-08-23T16:07:42Z
dc.date.available2024-08-23T16:07:42Z
dc.date.issued2023en_US
dc.departmentDüzce Üniversitesien_US
dc.description.abstractBackground: Surgical trauma may affect immunity and pave the way for septic complications. In our case, the intensive care follow-up of a patient who developed spondylodiscitis and diagnosed with immunodeficiency and ARDS-Sepsis was presented, and the literature was reviewed. Case: A 36-year-old male patient became immobile with severe pain after a lumbar disc hernia repair twenty-eight days ago. Antibiotherapy was started after the diagnosis of Spondylodiscitis by MRI (Figure 1). Due to his clinical deterioration, he was transferred to our intensive care unit with the preliminary diagnosis of ARDS-sepsis and acute renal failure. There were tachycardia, hypotension, hypoxia, anuria, with no infective findings in the operation area. Continuous venovenous hemodialysis and cytokine filter were applied to the patient. The cytokine filter was terminated on the third day with the regression of ARDS and infective parameters (Table 1), and the patient was followed up with high flow (fi0,:100 flow:60L/min). Hypoxia became evident on the seventh day, and the patient had to be intubated on the tenth day. Antibiotherapy was expanded due to acinetobacter and hyphae in deep tracheal aspirate. Deepening of thrombocytopenia was thought to be related to antibiotics. IgG level was 569 mg/dL (700-1600 mg/dL). Intravenous Ig (IVIG) was administered. As the cytopenia continued, it was thought that infection-related immune thrombocytopenia might have been added, and IVIG was planned again, the treatment was completed with clinical response. After sixty days of intensive care follow-up, the patient was removed from the intensive care unit by closing the tracheotomy. Conclusion: Spondylodiscitis is usually bacterial and occurs after surgery. Complications, constant source of infection, and prolonged antibiotic therapy may lead to multiple organ dysfunction syndrome (MODS) due to uncompensated excessive and prolonged proinflammatory responses in patients. Long-term hospitalization after surgery, immobility, malnutrition are predisposing factors to sepsis; it also reveals the imbalance of inflammatory and anti- inflammatory processes. Thus, prolonged immunodeficiency findings can be observed. The patient, who developed MODS and secondary immunodeficiency, was discharged after meticulous multidisciplinary follow-up. In conclusion, it should be kept in mind that the immune system may be suppressed in young and low-risk patients and the resulting sepsis may cause multi-organ damage. © 2023 Anestezi Dergisi. All rights reserved.en_US
dc.identifier.endpage128en_US
dc.identifier.issn1300-0578
dc.identifier.scopus2-s2.0-85176558103en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage125en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12684/14798
dc.identifier.volume31en_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherAnestezi Dergisien_US
dc.relation.ispartofAnestezi Dergisien_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectsecondary immune failureen_US
dc.subjectsepsisen_US
dc.subjectSpondylodiscitisen_US
dc.subjectalanine aminotransferaseen_US
dc.subjectanidulafunginen_US
dc.subjectaspartate aminotransferaseen_US
dc.subjectC reactive proteinen_US
dc.subjectcefoperazone plus sulbactamen_US
dc.subjectcolistinen_US
dc.subjectcytokineen_US
dc.subjectimmunoglobulin Gen_US
dc.subjectmeropenemen_US
dc.subjectmicafunginen_US
dc.subjectmoxifloxacinen_US
dc.subjectneuromuscular blocking agenten_US
dc.subjectpiperacillin plus tazobactamen_US
dc.subjectprocalcitoninen_US
dc.subjectsedative agenten_US
dc.subjectteicoplaninen_US
dc.subjectAcinetobacteren_US
dc.subjectAcinetobacter infectionen_US
dc.subjectacute kidney failureen_US
dc.subjectadulten_US
dc.subjectadult respiratory distress syndromeen_US
dc.subjectanamnesisen_US
dc.subjectantibiotic therapyen_US
dc.subjectantifungal therapyen_US
dc.subjectanuriaen_US
dc.subjectArticleen_US
dc.subjectautoimmune thrombocytopeniaen_US
dc.subjectbacterial growthen_US
dc.subjectblood cultureen_US
dc.subjectblood transfusionen_US
dc.subjectbone marrow biopsyen_US
dc.subjectcase reporten_US
dc.subjectclinical articleen_US
dc.subjectcoagulase negative Staphylococcusen_US
dc.subjectcontinuous hemodialysisen_US
dc.subjectcytopeniaen_US
dc.subjectdiskitisen_US
dc.subjectendotracheal intubationen_US
dc.subjectfollow upen_US
dc.subjectfraction of inspired oxygenen_US
dc.subjectfungus growthen_US
dc.subjectfungus hyphaeen_US
dc.subjectgeneral condition deteriorationen_US
dc.subjecthematuriaen_US
dc.subjecthemoptysisen_US
dc.subjecthumanen_US
dc.subjecthuman tissueen_US
dc.subjecthypercapniaen_US
dc.subjecthypotensionen_US
dc.subjecthypoxiaen_US
dc.subjectimmobilityen_US
dc.subjectimmune deficiencyen_US
dc.subjectimmunoglobulin blood levelen_US
dc.subjectintensive careen_US
dc.subjectintensive care uniten_US
dc.subjectkidney function testen_US
dc.subjectlaboratory testen_US
dc.subjectlumbar discectomyen_US
dc.subjectlumbar disk herniaen_US
dc.subjectmaleen_US
dc.subjectmultiple organ failureen_US
dc.subjectmycosisen_US
dc.subjectneuromuscular blockingen_US
dc.subjectnonhumanen_US
dc.subjectnoninvasive ventilationen_US
dc.subjectnuclear magnetic resonance imagingen_US
dc.subjectoxygen desaturationen_US
dc.subjectoxygenationen_US
dc.subjectpain severityen_US
dc.subjectpostoperative painen_US
dc.subjectprone positionen_US
dc.subjectremissionen_US
dc.subjectsedationen_US
dc.subjectsepsisen_US
dc.subjectsmearen_US
dc.subjectsputum cytodiagnosisen_US
dc.subjecttachycardiaen_US
dc.subjecttachypneaen_US
dc.subjectthorax radiographyen_US
dc.subjectthrombocytopeniaen_US
dc.subjecttracheal aspiration procedureen_US
dc.subjecttracheostomyen_US
dc.subjecttreatment responseen_US
dc.subjecturine cultureen_US
dc.titleSepsis Multi Organ Damage Due To Secondary Immune Failure After Spondylodiscitisen_US
dc.typeArticleen_US

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