The physiological and pathophysiological role of leptin in neurological and behavioral disorders
Küçük Resim Yok
Tarih
2023
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Nova Science Publishers, Inc.
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Many factors can impact behavioral problems, including genetic, physiological, structural, and psychological factors. The genesis of behavioral disorders is influenced by several elements as a result of this complicated relationship. Because hormones are so tightly linked to the brain and nervous system, behavioral issues might be hormonal. Because of receptor insensitivity, the number of hormones may drop or rise; the number of receptors may alter; and mutations may develop. Leptin is a hormone that is generated mostly by fatty tissue, although it can also be produced by the placenta, skeletal muscle, stomach, mammary epithelium, and brain tissue. The hypothalamus, one of the body's most important organs, regulates the hormone leptin's physiological role and systemic effect. The leptin hormone inhibits appetite while increasing energy consumption in the hypothalamus arcuate nucleus. Leptin has been shown to have both peripheral and central effects, interacting with the endocrine system and hence possibly impacting behavior. Eating disorders, schizophrenia, sleep, sexual behavior, depression, anxiety, anorexia nervosa, bipolar illness, borderline personality disorder, and alcohol use disorders have all been connected to leptin. According to studies, leptin has been linked to several behavioral illnesses, including depression. Furthermore, the interaction of antidepressants and antipsychotics with the hormone leptin has emerged as a new topic of research. The role of leptin in neurological and behavioral diseases is emphasized in this book chapter. The chapter discusses many features of leptin and emphasizes the significance of future research to better understand leptin's involvement in disease causes and therapy. © 2024 by Nova Science Publishers, Inc. All rights reserved.
Açıklama
Anahtar Kelimeler
Behavioral and neurological disorders, Leptin
Kaynak
Leptin and its Role in Health and Disease
WoS Q Değeri
Scopus Q Değeri
N/A
