Changes in Antibiotic Resistance of Children with Cystic Fibrosis and Impact on Clinical Outcomes

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dc.contributor.authorKılıç Sağlam, Mukaddes
dc.contributor.authorBaydemir, Canan
dc.contributor.authorUyan, Zeynep Seda
dc.date.accessioned2025-10-11T20:45:26Z
dc.date.available2025-10-11T20:45:26Z
dc.date.issued2025
dc.departmentDüzce Üniversitesien_US
dc.description.abstractAim: Antibiotics have an important role in the treatment of cystic fibrosis (CF) lung disease. Antibiotic resistance, especially multidrug resistance (MDR), increases in CF. This study aimed to determine whether there is a change in antibiotic resistance of pathogens isolated from the respiratory tract specimens of CF patients and to evaluate the relationship between the antibiotic resistance and patients’ clinical status and pulmonary function. Material and Methods: Thirty-nine CF patients with identified microorganisms in respiratory tract specimens from August 2010 through December 2016 were included in the study. 333 respiratory cultures taken from 39 CF patients were analyzed retrospectively. Results: Methicillin-sensitive S. aureus (MSSA) was isolated from 122 (31.0%) cultures, P. aeruginosa from 97 (24.7%), and methicillin-resistant S. aureus (MRSA) from 22 (5.6%). The prevalence of MSSA (p=0.020) and MRSA (p=0.010) increased from 2010 to 2016, while the prevalence of P. aeruginosa and other microorganisms did not increase. MDR-S. aureus and MDR-P. aeruginosa prevalence did not change, but MRSA prevalence increased over the years (p=0.001). There was a significant relation between the antibiotic resistance and acute pulmonary exacerbations, pulmonary examination findings, loss in weight and height percentile. As the antibiotic resistance increased, FEV1, FVC, FEV1/FVC, PEF, and FEF25-75 were significantly decreased. The use of long-term azithromycin or inhaled antibiotics was not associated with antibiotic resistance. Conclusion: In CF patients, resistance to antibiotics increased over the years. It is important to obtain respiratory tract cultures regularly and initiate rational antibiotic treatment based on culture results. © 2025 Elsevier B.V., All rights reserved.en_US
dc.identifier.doi10.18678/dtfd.1647114
dc.identifier.endpage171en_US
dc.identifier.issn1307-671X
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-105014643974en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage165en_US
dc.identifier.urihttps://doi.org/10.18678/dtfd.1647114
dc.identifier.urihttps://hdl.handle.net/20.500.12684/21357
dc.identifier.volume27en_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherDuzce University Medical Schoolen_US
dc.relation.ispartofDuzce Medical Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmzKA_Scopus_20250911
dc.subjectAntibiotic Resistanceen_US
dc.subjectCystic Fibrosisen_US
dc.subjectMultidrug Resistanceen_US
dc.subjectRespiratory Culturesen_US
dc.subjectAzithromycinen_US
dc.subjectFlowhandy Zan 100en_US
dc.subjectIbm Spss Statistics Version 20.0en_US
dc.subjectVitek 2en_US
dc.subjectAntibiotic Agenten_US
dc.subjectAzithromycinen_US
dc.subjectAntibiotic Resistanceen_US
dc.subjectArticleen_US
dc.subjectChilden_US
dc.subjectClinical Outcomeen_US
dc.subjectCystic Fibrosisen_US
dc.subjectEscherichia Colien_US
dc.subjectFemaleen_US
dc.subjectForced Expiratory Flowen_US
dc.subjectForced Expiratory Volumeen_US
dc.subjectForced Vital Capacityen_US
dc.subjectHumanen_US
dc.subjectLung Functionen_US
dc.subjectMaleen_US
dc.subjectMatrix Assisted Laser Desorption Ionization Time Of Flight Mass Spectrometryen_US
dc.subjectMethicillin Resistant Staphylococcus Aureusen_US
dc.subjectMultidrug Resistanceen_US
dc.subjectNasopharyngeal Aspirationen_US
dc.subjectPeak Expiratory Flowen_US
dc.subjectPrevalenceen_US
dc.subjectPseudomonas Aeruginosaen_US
dc.subjectPulmonologyen_US
dc.subjectRespiratory Systemen_US
dc.subjectRetrospective Studyen_US
dc.subjectSpirometryen_US
dc.subjectStaphylococcus Aureusen_US
dc.subjectStenotrophomonas Maltophiliaen_US
dc.titleChanges in Antibiotic Resistance of Children with Cystic Fibrosis and Impact on Clinical Outcomesen_US
dc.title.alternativeKistik Fibrozisli Çocuklarda Antibiyotik Direncindeki Değişimler ve Klinik Sonuçlar Üzerindeki Etkisien_US
dc.typeArticleen_US

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