Investigation of Antitumor Activity of Fenugreek Paste Extracts

Basit Öğe Kaydı
dc.contributor.authorAlpa, Serife
dc.contributor.authorÖzçelik, Özlem
dc.contributor.authorYilmaz, Seher
dc.contributor.authorErtekin, Tolga
dc.contributor.authorNisari, Mehtap
dc.contributor.authorŞeker Karatoprak, Gökçe
dc.contributor.authorÜlger, Harun
dc.date.accessioned2024-12-28T20:24:19Z
dc.date.available2024-12-28T20:24:19Z
dc.date.issued2024
dc.description.abstractObjective: Fenugreek paste, which contains fenugreek and some spices, is a widely consumed food in Kayseri and the surrounding region of Turkey. In this study, the antitumor effect of an extract obtained from fenugreek paste was investigated in Balb/C mice bearing Ehrlich ascites tumor (EAT). Materials and Methods: The concentration of fenugreek paste extract in vivo was 200 and 400 mg/kg and in vitro was 250, 500 and 1000 µg/ml. At the end of the experiment, the volume of abdominal ascites fluid was measured and cells were counted.Results: Fenugreek paste extract delayed weight gain due to EAT cell proliferation in the treatment groups and caused a significant decrease in the number of cells in the ascites fluid in the 400 mg/kg fenugreek paste extract group (47.28 × 106) compared to the control group (67.60 × 106; p = 0.041). Histopathological analysis showed that EAT cells intensely adhered to tissues from the control group and adhered less in the treatment groups. The decrease was more significant in the 400-mg/kg fenugreek extract group. After 24-hour culture, there was a significant difference in EAT cells between the control group (5.9 ± 0.2) and the 250-, 500- and 1000-µg/ml fenugreek paste extract treatment groups (5.7 ± 0.2, 5.7 ± 0.2, and 5.6 ± 0.1, respectively; p = 0.013).Conclusion: The study results suggested that fenugreek paste extract had an antitumor effect on EAT cells.
dc.identifier.dergiparkDergiPark: 1433242
dc.identifier.doi10.53811/ijtcmr.1433242
dc.identifier.endpage111
dc.identifier.issn2717-7491
dc.identifier.issue2
dc.identifier.startpage101
dc.identifier.urihttps://doi.org/10.53811/ijtcmr.1433242
dc.identifier.urihttps://dergipark.org.tr/tr/download/article-file/3713061
dc.identifier.urihttps://dergipark.org.tr/tr/pub/ijtcmr/issue/86971/1433242
dc.identifier.urihttps://hdl.handle.net/20.500.12684/17203
dc.identifier.volume5
dc.language.isoen
dc.publisherDüzce Üniversitesi
dc.relation.ispartofInternational Journal of Traditional and Complementary Medicine Research
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241228
dc.subjectEhrlich ascites tumor
dc.subjectFenugreek paste
dc.subjectFenugreek
dc.subjectRed pepper
dc.subjectGarlic
dc.subjectTraditional Chinese Medicine and Treatments
dc.titleInvestigation of Antitumor Activity of Fenugreek Paste Extracts
dc.typeArticle

Dosyalar

Koleksiyon

International Journal of Traditional and Complementary Medicine Research