Serum bilirubin levels in Turkish adults show inverse relation with insulin resistance and overall obesity, without association with metabolic syndrome

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dc.contributor.authorOnat, Altan
dc.contributor.authorÖzhan, Hakan
dc.contributor.authorKarabulut, Ahmet
dc.contributor.authorAlbayrak, Sinan
dc.contributor.authorCan, Günay
dc.contributor.authorHergenç, Gülay
dc.date.accessioned2020-04-30T13:33:21Z
dc.date.available2020-04-30T13:33:21Z
dc.date.issued2007
dc.departmentDÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractObjectives: We investigated serum bilirubin levels and their association with insulin resistance (IR), metabolic syndrome (MS) or its components, and coronary heart disease (CHD) among Turkish adults. Study design: Serum bilirubin concentrations were measured in 1,052 male and female participants of a representative cross-sectional Turkish cohort living in the Marmara and Middle Anatolia regions. Metabolic syndrome was defined by modified criteria of the Adult Treatment Panel III. Results: The median age of the cohort was 53 years. Metabolic syndrome was identified in 235 males (46%) and 253 females (46.8%). The mean serum bilirubin concentration was 0.59±0.34 mg/dl in males, and 0.53±0.34 mg/dl in females (p=0.004). Serum bilirubin levels showed significant positive correlations with serum protein, albumin, testosterone, age, diastolic blood pressure, creatinine, and folic acid, and inverse correlations with smoking, body mass index, and IR. Serum bilirubin was correlated with HDL-cholesterol only in males. Of these factors, obesity, IR (inversely), and diastolic blood pressure were the main independent covariates of serum bilirubin. Logistic regression analysis showed that IR was significantly associated with the bottom quartile of bilirubin (?0.34 mg/dl) (OR: 1.91; 95% CI: 1.14-3.18), with a stronger association only in females (OR: 2.43; 95% CI 1.21-4.88). Bilirubin levels were not in significant association with CHD and MS. Conclusion: Insulin resistance, but not MS components related with central obesity, was associated with low levels of serum bilirubin in Turkish adults. This relation is more prominent among females and supports the hypothesis that serum bilirubin possesses antioxidant function.en_US
dc.identifier.endpage36en_US
dc.identifier.issn1016-5169
dc.identifier.issue1en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage28en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12684/616
dc.identifier.volume35en_US
dc.indekslendigikaynakScopusen_US
dc.language.isotren_US
dc.relation.ispartofTurk Kardiyoloji Dernegi Arsivien_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBilirubin/blood; Coronary disease; Insulin resistance; Metabolic syndrome X; Obesity; Sex factorsen_US
dc.titleSerum bilirubin levels in Turkish adults show inverse relation with insulin resistance and overall obesity, without association with metabolic syndromeen_US
dc.title.alternativeTürk yetişkinlerinde bilirübin düzeyleri insülin direnci ve obezite ile ters ilişki içinde, metabolik sendromla ise ilişkili de?ilen_US
dc.typeArticleen_US

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