Synthesis and Characterization of Some New 4-Methyl-5-Imidazole Carbaldehyde Derivatives
| dc.authorid | ||
| dc.contributor.author | Orhan, Ersin | |
| dc.contributor.author | Köse, Mahmut | |
| dc.contributor.author | Alkan, Demet | |
| dc.contributor.author | Öztürk, Leyla | |
| dc.date.accessioned | 2021-12-01T18:23:01Z | |
| dc.date.available | 2021-12-01T18:23:01Z | |
| dc.date.issued | 2019 | |
| dc.department | [Belirlenecek] | en_US |
| dc.description.abstract | Imidazole is a common and important heterocyclic fragment of many biologically importantmolecules. 5-imidazole-carbaldehydes containing mono- (N-1) methyl (or aryl) analogs are commonlyused as building blocks in medical chemistry. In this study, starting from 4-methyl-1H-imidazole-5-carbaldehyde, the N-1 atom of the imidazole ring is derived with different alkyl groups. In addition,both N atoms of the starting imidazole-carbaldehyde were methylated to give 5-carbaldehyde-1,3,4-trimethyl-3-imidazolium salt. The salt which possess quite reactive carbaldehyde group could be usedas a precursor for synthesis of other imidazolium derivatives. Furthermore, 4-methyl-5-imidazolecarbaldehyde was converted into the benzoxazole, benzothiazole and benzoimidazole by a two-stepreaction over the aldehyde group. These new compounds could display some biological activities. | en_US |
| dc.identifier.doi | 10.18596/jotcsa.530757 | |
| dc.identifier.endpage | 382 | en_US |
| dc.identifier.issn | 2149-0120 | |
| dc.identifier.issn | 2149-0120 | |
| dc.identifier.issue | 3 | en_US |
| dc.identifier.startpage | 373 | en_US |
| dc.identifier.uri | https://doi.org/10.18596/jotcsa.530757 | |
| dc.identifier.uri | https://app.trdizin.gov.tr/makale/TXprMk16UTNOdz09 | |
| dc.identifier.uri | https://hdl.handle.net/20.500.12684/9620 | |
| dc.identifier.volume | 6 | en_US |
| dc.indekslendigikaynak | TR-Dizin | en_US |
| dc.language.iso | en | en_US |
| dc.relation.ispartof | Journal of the Turkish Chemical Society, Section A: Chemistry | en_US |
| dc.relation.publicationcategory | Makale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
| dc.rights | info:eu-repo/semantics/openAccess | en_US |
| dc.subject | [No Keywords] | en_US |
| dc.title | Synthesis and Characterization of Some New 4-Methyl-5-Imidazole Carbaldehyde Derivatives | en_US |
| dc.type | Article | en_US |
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